Navigation Links
Human muscle stem cell therapy gets help from zebrafish
Date:11/7/2013

Harvard Stem Cell Scientists have discovered that the same chemicals that stimulate muscle development in zebrafish can also be used to differentiate human stem cells into muscle cells in the laboratory, an historically challenging task that, now overcome, makes muscle cell therapy a more realistic clinical possibility.

The work, published this week in the journal Cell, began with a discovery by Boston Children's Hospital researchers, led by Leonard Zon, MD, and graduate student Cong (Tony) Xu, who tested 2,400 different chemicals in cultures of zebrafish embryo cells to determine if any could increase the numbers of muscle cells formed. Using fluorescent reporter fish in which muscle cells were visible during their creation, the researchers found six chemicals that were very effective at promoting muscle formation.

Zon shared his results with Harvard Department of Stem Cell and Regenerative Biology professor Amy Wagers, PhD, and Mohammadsharif Tabebordbar, a graduate student in her laboratory, who tested the six chemicals in mice. One of the six, called forskolin, was found to increase the numbers of muscle stem cells from mice that could be obtained when these cells were grown in laboratory dishes. Moreover, the cultured cells successfully integrated into muscle when transplanted back into mice.

Inspired by the successful application of these chemicals in mice, Salvatore Iovino, PhD, a joint postdoctoral fellow in the Wagers lab and the lab of C. Ronald Kahn, MD, at the Joslin Diabetes Center, investigated whether the chemicals would also affect human cells and found that a combination of three chemicals, including forskolin, could induce differentiation of human induced pluripotent stem (iPS) cells, made by reprogramming skin cells. Exposure of iPS cells to these chemicals converted them into skeletal muscle, an outcome the Wagers and Kahn labs had been striving to achieve for years using conventional methods. When transp
'/>"/>

Contact: B. D. Colen
bd_colen@harvard.edu
617-495-7821
Harvard University
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. Integrated 3-D Imaging Facilitates Human Face Transplantation
2. Roche NimbleGen and BGI Develop Advanced MHC Region Capture Technology for Human Disease and Biomedical Research
3. Singapore scientists lead human embryonic stem cell study
4. AFFiRiS AG Invests Into Human Capital - Chief Business Officer Recruited
5. ReproCELL Licensed Commercialization Right on Human iPS Cell Derived Hepatocytes - Expected Launch in Q2 2012
6. Cepheid Welcomes Senior Vice President of Human Resources
7. deCODE Genetics, in Collaboration with Academic Colleagues, Discovers Three Variants in the Sequence of the Human Genome that Affect the Risk of Thyroid Cancer
8. Foundation for Angelman Syndrome Therapeutics (FAST) Funds Human Clinical Trial
9. Successful human tests for first wirelessly controlled drug-delivery chip
10. First successful human results achieved: Implantable wireless microchip drug delivery device
11. Human Pheromone Sciences Voluntarily Files With SEC for Termination of Registration
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/15/2014)... Scottsdale, Arizona (PRWEB) January 15, 2014 ... growth for Scottsdale’s Brain State Technologies®. They saw continued ... University Medical Center who were awarded a $1 million ... papers published in “Brain and Behavior” a peer reviewed ...
(Date:1/15/2014)... AudioNotch is the internet's leading provider ... treatment of tinnitus. Patients listen to sound therapy that ... period of weeks to months, their tinnitus volume decreases. , ... Notched Music and Notched White Noise. Now, AudioNotch is pleased ...
(Date:1/14/2014)... (PRWEB) January 14, 2014 Date: Friday, April ... Location: Warrington Country Club, 1360 Almshouse Road, Warrington, Pa. ... nonprofit organization solely dedicated to finding a cure for hepatitis ... worldwide, will host its annual Crystal Ball on Friday, April ...
(Date:1/14/2014)... San Diego, CA (PRWEB) January 14, 2014 ... based on the products of cells grown under simulated ... an international license agreement with Suneva Medical, Inc. for ... media (CCM). , This agreement is an ...
Breaking Biology Technology:Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3Hepatitis B Foundation to Host Annual Crystal Ball Gala 2Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 2Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 3
... This release is available in German ... say, on plastic foils, have excellent potential to lower ... called "balance-of-system" cost, thus enabling affordable solar electricity in ... on polymer films have been lacking behind in performance ...
... Generex Biotechnology Corporation,s (OTCBB: GNBT) ( www.generex.com ) wholly-owned ... that its lead drug candidate AE37, a novel HER-2/neu-targeted ... of breast cancer, is featured in the October 2011 ... titled "A New Ally Against Cancer" by Eric von ...
... NEW YORK, Sept. 21, 2011 Reportlinker.com announces ... in its catalogue: Separation ... http://www.reportlinker.com/p0619255/Separation-Systems-for-Commercial-Biotechnology.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Biotechnology THIS REPORT ... the U.S. market for separation systems for commercial ...
Cached Biology Technology:How to produce flexible CIGS solar cells with record efficiency 2Antigen Express' AE37 Cancer Vaccine Featured in Scientific American 2Antigen Express' AE37 Cancer Vaccine Featured in Scientific American 3Antigen Express' AE37 Cancer Vaccine Featured in Scientific American 4Separation Systems for Commercial Biotechnology 2Separation Systems for Commercial Biotechnology 3Separation Systems for Commercial Biotechnology 4Separation Systems for Commercial Biotechnology 5Separation Systems for Commercial Biotechnology 6Separation Systems for Commercial Biotechnology 7Separation Systems for Commercial Biotechnology 8Separation Systems for Commercial Biotechnology 9Separation Systems for Commercial Biotechnology 10Separation Systems for Commercial Biotechnology 11
(Date:7/10/2014)... inflammatory skin diseases psoriasis* and eczema** are similar in ... base their decision on which treatment should be selected ... samples. A team of researchers at the Helmholtz Zentrum ... now analyzed the molecular processes that occur in both ... for the first time to gain a detailed understanding ...
(Date:7/9/2014)... pivotal in the development of cancer, viral infection and ... question about one of the most widely-researched proteins in ... of thousands of research papers and millions of pounds ... in Professor Sir Philip Cohen,s laboratory at the University ... is activated. The results are published today ...
(Date:7/9/2014)... LAFAYETTE, Ind. - Regulated deer hunts in Indiana state ... from decades of damage caused by overabundant populations of ... team led by Michael Jenkins, associate professor of forest ... Resources policy of organizing hunts in state parks has ... and wildflowers rendered scarce by browsing deer. , ...
Breaking Biology News(10 mins):New diagnostic test to distinguish psoriasis from eczema 2Research reveals how key controller protein is switched on 2Hunting gives deer-damaged forests in state parks a shot at recovery 2
... The American Psychological Association, the largest psychological ... "Distinguished Scientific Award for Early Career Contribution to ... Research Institute at the University of Veterinary Medicine, ... Range,s ground-breaking research on animal cognition and will ...
... the researchers to see an aspect of light that humans ... sensitive to polarized light, many reef dwelling animals are but ... studies of reef communities. Thanks to generous support provided ... team of researchers from the Ecology of Vision Laboratory in ...
... of rare, endemic species in the Central Andes remain ... climate change, according to a Duke University-led international study. ... particularly vulnerable to changes in the environment or climate. ... percent of the areas with high numbers of these ...
Cached Biology News:Dancing with wolves -- prestigious award goes to a scientist at the Vetmeduni Vienna 2Capturing an octopus-eye view of the Great Barrier Reef 280 percent of 'irreplaceable' habitats in Andes unprotected 2
... fixative useful for routine procedures. Hollandes contains ... and will decalcify small bone specimens. Tissue ... stained successfully with most stains, and the ... blood cell membranes and cosinophil and endocrine ...
... fixative useful for routine procedures. Hollandes contains ... and will decalcify small bone specimens. Tissue ... stained successfully with most stains, and the ... blood cell membranes and cosinophil and endocrine ...
Chicken polyclonal antibody to Glutathione-S-Transfrease (GST)...
... Acuity is the complete enterprise microarray informatics platform ... analysis. Buy Acuity once and use it forever ... Tools for Quality Acuity has all the ... from your data, from quality control statistics and ...
Biology Products: