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Human clinical study demonstrates superior Neptune Krill Oil NKO(R) pharmacokinetic profile
Date:11/19/2008

e erythrocyte.

The results of the study clearly demonstrate that NKO(R): a) provides a rapid and significantly high bioavailability of EPA and DHA even at unprecedented low daily dose and b) achieves a significantly higher bioavailability compared to successfully marketed nutraceutical and pharmaceutical omega-3 formulations, c) achieves a significantly greater reduction of the EPA/ arachidonic acid index and d) achieves a significantly greater increase of the omega-3 index within the erythrocyte lifespan of 120 days.

The positive effect of Neptune phospholipids on the EPA/ arachidonic acid index and the omega-3 index, which are recognized markers for cardiovascular risk, reinforces the previously proven cardiovascular and anti-inflammatory benefits of Neptune phospholipids, namely increasing HDL ("good cholesterol") and decreasing LDL ("bad cholesterol") as well as CRP ("C-reactive protein", an inflammatory marker), and as such strengthening their position in cardiovascular management.

"This is a very important clinical study for both Neptune and Acasti Pharma. Because of the low physiological daily dose used, the clinical study establishes new grounds for the methodology of bioavailability assessment for omega-3 fatty acids. It is the first human clinical trial demonstrating the superior pharmacokinetic profile and as such supporting the rationale of the superiority of Neptune proprietary compositions, which form the basis of our omega-3 phospholipids nutraceutical and pharmaceutical pipeline," said Dr. Tina Sampalis, Chief Scientific Officer of Neptune. "The results also show that NKO(R), a patented formula, cannot be simply mimicked by blending different constituents together and that the bioactive ingredients must be extracted keeping the physiological activity of the phospholipids intact, which we manage through our proprietary manufacturing process," she added.

About Acasti Pharma

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SOURCE NEPTUNE TECHNOLOGIES & BIORESSOURCES INC.
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