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Human Genome Sciences and Xencor Announce Antibody Collaboration
Date:2/7/2008

e antibody structure, including the Fc region to improve potency and half-life and variable region humanization and affinity optimization. We look forward to working with Human Genome Sciences to create novel, best-in-class biotherapeutics that are more effective in treating unmet medical needs while we continue to advance our internal pipeline of XmAb antibody candidates."

About XmAb(TM) Technologies

Xencor's XmAb engineered Fc domains are designed to enhance the therapeutic properties of monoclonal antibodies and can be inserted into antibody candidates against any target antigen to improve one or more important effector functions, including enhanced antibody-mediated tumor cell killing, extended half-life and selective regulation of immune cells. The XmAb(TM) Fv technology generates high-quality human sequence diversity in antibody variable domains in order to improve affinity, stability and production yield.

About Xencor, Inc.

Xencor, Inc. engineers superior biotherapeutics using its proprietary Protein Design Automation(R) technology platform and is a leader in the field of antibody Fc engineering to significantly improve antibody potency and half- life. The company is advancing XmAb(TM) antibody drug candidates optimized for activity against biologically validated targets and its XPro(TM) protein therapeutic candidate into the clinic. Xencor's product development is led by an antibody candidate, XmAb(TM)2513, for the treatment of Hodgkin's disease and T-cell lymphoma, and a protein therapeutic drug candidate, XPro(TM)1595 DN-TNF, for the treatment of inflammatory disease. With multiple partners, such as industry leaders Genentech, Boehringer Ingelheim, Centocor and MedImmune, Xencor is applying its suite of XmAb antibody Fc domains to improve antibody drug candidates for traits such as potency and sustained half-life. For more information, please visit http://www.xencor.com.

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SOURCE Human Genome Sciences, Inc.
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