Navigation Links
Human Genome Sciences and Aegera Therapeutics Announce Licensing and Collaboration Agreement on Novel Anti-Cancer Drugs
Date:12/20/2007

- HGS acquires exclusive rights to develop and commercialize small-molecule

IAP inhibitors in oncology - - Lead compound AEG40826 works synergistically with HGS TRAIL receptor

antibodies to enhance anticancer activity of both drugs - - IAP inhibitors also show promise alone and in combination with other

anti- cancer agents across broad range of cancers -

ROCKVILLE, Md. and MONTREAL, Quebec, Dec. 20 /PRNewswire-FirstCall/ -- Human Genome Sciences, Inc. (Nasdaq: HGSI) and Aegera Therapeutics Inc. today announced an agreement under which HGS has acquired exclusive worldwide rights (excluding Japan) to develop and commercialize AEG40826 and related backup compounds to be chosen during a three-year research collaboration. AEG40826 is a potent small-molecule inhibitor of multiple IAP (inhibitor of apoptosis) protein family members that is expected to begin oncology clinical trials in early 2008.

"Today's announcement underscores HGS's commitment to develop novel targeted therapies for the treatment of cancer," said H. Thomas Watkins, President and Chief Executive Officer, HGS. "Our company has pioneered development of antibody therapies based on the TRAIL receptor apoptotic pathway, and we will now have the opportunity to work collaboratively with Aegera Therapeutics to develop and commercialize exciting small-molecule drugs that also enhance apoptosis in cancer cells. We look forward to developing our TRAIL receptor antibodies and IAP inhibitors in combination with one another and in combination with other therapeutic agents. We believe this agreement substantially enhances the value of our promising oncology franchise."

Under the agreement, HGS has paid Aegera an upfron
'/>"/>

SOURCE Human Genome Sciences, Inc.
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related biology technology :

1. Expiry of Hart-Scott-Rodino Waiting Period for JUVISTA(R) (Human TGF BETA 3)
2. New Initiative Has Shocking Effect: Thousands of Missourians with Abnormal Chromosome Structures Are Not Human
3. ExonHit Therapeutics: Allergan and ExonHits First Collaboration Compound to Begin Human Clinical Trials
4. Human Genome Sciences Announces $40 Million Milestone Payment Related to Albuferon(R) Development
5. Novocell Announces Discovery Linking Key Cancer Cell Signaling Pathways With Proliferation and Self-Renewal of Human Embryonic Stem Cells
6. Human Genome Sciences Invites Investors to Listen to Webcast of Presentation at Thomas Weisel Partners Conference
7. Human Genome Sciences Invites Investors to Listen to Webcast of Presentation at BioCentury-Thomson Financial Investment Conference
8. Human Genome Sciences Invites Investors to Listen to Webcast of Presentation at Bear Stearns Conference
9. Human Pheromone Sciences Enters Into Agreement to Reposition and Promote its Natural Attraction(R) Brand
10. Human Genome Sciences Invites Investors to Listen to Webcast of Presentation at Merrill Lynch Conference
11. Premier Research Appoints Global Head of Human Resources
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/4/2015)... 4, 2015 /PRNewswire/ - Fluorinov Pharma (Fluorinov), a ... appointment of Dr. Roger J Garceau, to its ... companies in matters including corporate development and clinical ... adds significant regulatory expertise as Fluorinov transitions to ... 30 years of pharmaceutical development experience to Fluorinov ...
(Date:5/4/2015)... May 04, 2015 Genedata, a ... discovery and life science research, today announced the ... latest version of its enterprise solution for biologics ... enables more efficient discovery and development of novel ... integrate and address protein optimization and developability requirements. ...
(Date:5/4/2015)... HONG KONG , May 4, 2015 ... or the "Company"), China,s leading ... cell processing and stem cell storage services, today announced ... Holdings Limited ("Golden Meditech"), a Hong Kong ... the Company, has entered into an agreement (the "Agreement") ...
(Date:5/4/2015)... 2015   Intrexon Corporation (NYSE: XON ... financial results after the market closes on May 11, ... day at 5:30 PM ET to discuss the results ... conference call may be accessed by dialing 1-888-346-3959 (Domestic ... "Intrexon Conference Call."  Participants may also access the live ...
Breaking Biology Technology:Roger J Garceau joins Fluorinov board, adds clinical expertise to bromodomain program and oncology pipeline 2Roger J Garceau joins Fluorinov board, adds clinical expertise to bromodomain program and oncology pipeline 3Genedata Biologics 5.0 – Antibody Engineering and Developability Assessment Advances 2Genedata Biologics 5.0 – Antibody Engineering and Developability Assessment Advances 3Genedata Biologics 5.0 – Antibody Engineering and Developability Assessment Advances 4China Cord Blood Corporation Receives Notice of a Transaction Regarding its 7% Senior Convertible Notes Due 2017 Held by KKR 2China Cord Blood Corporation Receives Notice of a Transaction Regarding its 7% Senior Convertible Notes Due 2017 Held by KKR 3Intrexon to Announce First Quarter 2015 Financial Results on Monday, May 11, 2015 2
... Results: MIT electrical engineers have proposed a new ... high-resolution electron microscopes: they cannot be used to ... samples. The researchers suggest using a quantum mechanical ... remotely without ever hitting the imaged objects, thus ...
... ... contamination control products, introduces CapSure™ Technology, advancing the performance of cleanroom wipers on ... ... Corporation, a manufacturer of contamination control products for cleanroom and critical environments, introduces ...
... See for High-Paying Jobs and Economic Revitalization Across State ... Resources Defense Council (NRDC) will release a major new report ... energy jobs have to prove a major boost to farm ... With steady winds and ample access to the raw materials ...
Cached Biology Technology:Potential leap forward in electron microscopy 2New CapSure™ Cleanroom Wiper from Berkshire Corporation Captures and Retains 42 Times More Contaminant Particles 2A New Economic Future for Rural Indiana?: Study to Show How Renewable Energy Could Trigger Boom for Economically Struggling Areas in State 2
(Date:4/1/2015)... Apr. 1, 2015  NXT-ID, Inc. (NASDAQ: NXTD ... focused on the growing mobile commerce market, announces the ... wallets is underway to early access pre-order customers. ... usage at retail outlets including Walmart, Target, AT&T, Dunkin, ... Wocket was accepted at all outlets and very easy ...
(Date:3/26/2015)... , March 26, 2015 The ... social, recreation and athletic club, today announced it has ... allow freedom of movement for members and staff, while ... a comprehensive process, we selected FST,s IMID Access system ... convenience for our members and staff, in addition to ...
(Date:3/23/2015)... SoundView Technology Group issues a new research update following the ... wallet. SoundView was one of the selected user groups to provide ... in multiple scenarios and outlets. Soundview shares ... both debit and credit card payments.  Soundview ... meets their plans in 2015, it would push our IV ...
Breaking Biology News(10 mins):NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 2NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 3NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 4Granite Club First Private Club in North America to Implement FST Biometrics Secure Access Solution, as Part of Multi-million Dollar Expansion 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 3Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 4
... BOSTON--Researchers at Dana-Farber Cancer Institute have discovered a ... cancer recurrence in certain breast tumors that have been ... resistance to drugs of the anthracycline class, the breast ... vulnerable to other types of chemotherapy agents, say scientists ...
... and moths are welcome visitors to many plant species. ... and scents of their flowers to ensure fertilization and ... plant: Once attracted by the flower,s scent, they lay ... young caterpillars hatch. Scientists from the Max Planck Institute ...
... makes cameo appearances throughout the body, but its leading ... response, jump-starting the process along the hypothalamus-pituitary-adrenal (HPA) axis. ... found that CRF also plays a part in the ... division of the insulin-producing beta cells. These findings, ...
Cached Biology News:Genes found linked to breast cancer drug resistance could guide future treatment choices 2Genes found linked to breast cancer drug resistance could guide future treatment choices 3Genes found linked to breast cancer drug resistance could guide future treatment choices 4Changing flowering times protect tobacco plants against insect herbivory 2Changing flowering times protect tobacco plants against insect herbivory 3Changing flowering times protect tobacco plants against insect herbivory 4Stress peptide and receptor may have role in diabetes 2Stress peptide and receptor may have role in diabetes 3
... The Precision Slide Table is designed ... double bore design provides maximum force output ... has four sets of stainless steel ball ... Bumpers or self-compensating shock absorbers provide ...
Hamster Serum; U.S. sourced, ideal for those who seek an uncompromising quality. Low Hemoglobin levels; U.S. sourced, ideal for those who seek an uncompromising quality. Low Hemoglobin levels....
... cDNA Labeling System - dCTP with ... For the generation and purification of ... packaged together for complete cDNA labeling ... be used for performing labeling reactions ...
... Post-Labeling Kit with CyScribe GFX Purification ... and purification of Cy3- and Cy5-labeled ... complete cDNA labeling and purification.Flexible and ... performing labeling reactions with either Cy3- ...
Biology Products: