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Human Genome Sciences and Aegera Therapeutics Announce Licensing and Collaboration Agreement on Novel Anti-Cancer Drugs
Date:12/20/2007

- HGS acquires exclusive rights to develop and commercialize small-molecule

IAP inhibitors in oncology - - Lead compound AEG40826 works synergistically with HGS TRAIL receptor

antibodies to enhance anticancer activity of both drugs - - IAP inhibitors also show promise alone and in combination with other

anti- cancer agents across broad range of cancers -

ROCKVILLE, Md. and MONTREAL, Quebec, Dec. 20 /PRNewswire-FirstCall/ -- Human Genome Sciences, Inc. (Nasdaq: HGSI) and Aegera Therapeutics Inc. today announced an agreement under which HGS has acquired exclusive worldwide rights (excluding Japan) to develop and commercialize AEG40826 and related backup compounds to be chosen during a three-year research collaboration. AEG40826 is a potent small-molecule inhibitor of multiple IAP (inhibitor of apoptosis) protein family members that is expected to begin oncology clinical trials in early 2008.

"Today's announcement underscores HGS's commitment to develop novel targeted therapies for the treatment of cancer," said H. Thomas Watkins, President and Chief Executive Officer, HGS. "Our company has pioneered development of antibody therapies based on the TRAIL receptor apoptotic pathway, and we will now have the opportunity to work collaboratively with Aegera Therapeutics to develop and commercialize exciting small-molecule drugs that also enhance apoptosis in cancer cells. We look forward to developing our TRAIL receptor antibodies and IAP inhibitors in combination with one another and in combination with other therapeutic agents. We believe this agreement substantially enhances the value of our promising oncology franchise."

Under the agreement, HGS has paid Aegera an upfron
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SOURCE Human Genome Sciences, Inc.
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