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Human Genome Sciences Initiates Second Randomized Phase 2 Trial of HGS-ETR1 in Combination With Chemotherapy
Date:12/20/2007

ath in the U.S. in both men and women.

About HGS-ETR1

HGS-ETR1 (mapatumumab) is an agonistic human monoclonal antibody that directly induces cancer-cell death by specifically binding to and activating the protein known as TRAIL receptor 1. Using genomic techniques, HGS originally identified the TRAIL receptor-1 protein. The HGS-ETR1 antibody was generated by HGS through collaboration with Cambridge Antibody Technology. HGS is developing HGS-ETR1 as a potential treatment for a broad range of cancers. GlaxoSmithKline (GSK) has exercised its option under a June 1996 agreement to develop and commercialize HGS-ETR1 jointly with HGS. Under the terms of the agreement, GSK and HGS will share equally in Phase 3/4 development costs, and will share equally in sales and marketing expenses and profits of any product commercialized.

Conference Call

HGS management will hold a conference call today to discuss this announcement, as well as a separate announcement that HGS has acquired from Aegera Therapeutics the exclusive worldwide rights (excluding Japan) to develop and commercialize AEG40826, a potent small-molecule IAP inhibitor that is expected to enter Phase 1 clinical trials for the treatment of cancer in early 2008. The conference call will be held at 11 AM Eastern time. Participants may listen to the call by dialing 888-233-8128 or 913-312-0734, passcode 2718784, five to 10 minutes before the start of the call. A replay of the conference call will be available for several days by dialing 888-203- 1112 or 719-457-0820, passcode 2718784. This conference call also will be webcast. Interested parties who wish to listen to the webcast should visit the HGS website at http://www.hgsi.com. The archive of the conference call will be made available within a few hours after the call and will remain available for several days.

About Human Genome Sciences

The mission of HGS is to apply great scienc
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SOURCE Human Genome Sciences, Inc.
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