Navigation Links
Human Genome Sciences Initiates Second Randomized Phase 2 Trial of HGS-ETR1 in Combination With Chemotherapy
Date:12/20/2007

ROCKVILLE, Md., Dec. 20 /PRNewswire-FirstCall/ -- Human Genome Sciences, Inc. (Nasdaq: HGSI) announced today that it has initiated dosing of patients in a Phase 2 clinical trial of HGS-ETR1 (mapatumumab) in combination with the chemotherapy agents paclitaxel and carboplatin as first-line therapy in patients with advanced non-small cell lung cancer.

"The majority of patients who are newly diagnosed with non-small cell lung cancer have locally advanced or metastatic disease that is currently incurable," said Philip D. Bonomi, M.D., a principal investigator in the study, and Section Director, Medical Oncology, Rush University Medical Center, Chicago. "Fewer than half of these patients are candidates for surgery. There is an urgent medical need for effective treatment options for non-small cell lung cancer because current treatment strategies have only a minimal impact on survival. We look forward to evaluating the potential of HGS-ETR1 plus chemotherapy to offer a new approach to the first-line treatment of this deadly disease."

HGS-ETR1 is a human monoclonal antibody to TRAIL receptor 1, a protein involved in programmed cell death (apoptosis). The first randomized Phase 2 trial of HGS-ETR1 is currently underway in combination with bortezomib (Velcade) in patients with advanced multiple myeloma. HGS expects to have data available from the multiple myeloma study by mid-2008. In a separate press release issued earlier today, HGS and Aegera Therapeutics Inc. announced that HGS has acquired exclusive worldwide rights (excluding Japan) to develop and commercialize AEG40826, a potent small-molecule inhibitor of multiple proteins in the IAP (inhibitor of apoptosis) family that is expected to enter Phase 1 clinical trials for the treat
'/>"/>

SOURCE Human Genome Sciences, Inc.
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related biology technology :

1. Expiry of Hart-Scott-Rodino Waiting Period for JUVISTA(R) (Human TGF BETA 3)
2. New Initiative Has Shocking Effect: Thousands of Missourians with Abnormal Chromosome Structures Are Not Human
3. ExonHit Therapeutics: Allergan and ExonHits First Collaboration Compound to Begin Human Clinical Trials
4. Human Genome Sciences Announces $40 Million Milestone Payment Related to Albuferon(R) Development
5. Novocell Announces Discovery Linking Key Cancer Cell Signaling Pathways With Proliferation and Self-Renewal of Human Embryonic Stem Cells
6. Human Genome Sciences Invites Investors to Listen to Webcast of Presentation at Thomas Weisel Partners Conference
7. Human Genome Sciences Invites Investors to Listen to Webcast of Presentation at BioCentury-Thomson Financial Investment Conference
8. Human Genome Sciences Invites Investors to Listen to Webcast of Presentation at Bear Stearns Conference
9. Human Pheromone Sciences Enters Into Agreement to Reposition and Promote its Natural Attraction(R) Brand
10. Human Genome Sciences Invites Investors to Listen to Webcast of Presentation at Merrill Lynch Conference
11. Premier Research Appoints Global Head of Human Resources
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/26/2014)... YORK, NOVEMBER 21, 2014 (PRWEB) November 26, 2014 ... largest health-oriented communications network, today announced the organization has ... Annual Rx Club Awards. Digitas Health LifeBrands was honored ... while four other PHCG agencies received eight Awards of ... the creative aspects of pharmaceutical advertising and promotion. The ...
(Date:11/26/2014)... 2014 The North America Thermal ... market for detailed analysis of the growth trends ... reach $616.3 million by 2018, growing at a ... Browse through the TOC of the North America ... idea of the in-depth analysis and industry segmentation ...
(Date:11/26/2014)... PHILADELPHIA , Nov. 26, 2014 ... environments. Human exploration of space requires astronauts to maintain ... safety and success, and prevent potential errors and accidents. ... little is known about how cognition is affected by ... affected. Now, Penn Medicine researchers are poised ...
(Date:11/26/2014)... The ETC (Emerging Technology Centers) ... centers, announced today that applications for AccelerateBaltimore™ (AB) ... “Do you have a big idea?,” asked ETC’s ... know about it. AccelerateBaltimore helps you and your ... just 13 weeks.” Interested game changers with ...
Breaking Biology Technology:Publicis Healthcare Wins 20 Rx Club Awards 2Publicis Healthcare Wins 20 Rx Club Awards 3The North America Thermal Protective Clothing Market is estimated to grow up to $616.3 million by 2018 - Report by MicroMarket Monitor 2The North America Thermal Protective Clothing Market is estimated to grow up to $616.3 million by 2018 - Report by MicroMarket Monitor 3Penn Medicine Team Develops Cognitive Test Battery to Assess the Impact of Long Duration Spaceflights on Astronauts' Brain Function 2Penn Medicine Team Develops Cognitive Test Battery to Assess the Impact of Long Duration Spaceflights on Astronauts' Brain Function 3Penn Medicine Team Develops Cognitive Test Battery to Assess the Impact of Long Duration Spaceflights on Astronauts' Brain Function 4AccelerateBaltimore Applications to Close in 6 Days 2AccelerateBaltimore Applications to Close in 6 Days 3
... ... sales success need to understand Key Performance Indicators (KPIs) that gauge the potential for ... to generate more business and income in a new article at www.YouCanSell.com . ... Albuquerque, NM ...
... ... In the India, CJP is all set to hold ... 20-24, 2010. The JatrophaWorld Training Programme 2010-- the Most Authoritative platform ... R&D progress, and application technologies, including utilization of Jatropha Crude Oil ...
... can operate efficiently and last a long time is a ... to the assembly line. The precious metal platinum has been ... downsides: It is expensive, and it breaks down over time ... Brown University report a promising advance. They have created a ...
Cached Biology Technology:Use Key Performance Indicators to Generate Sales Success Says Expert Lenann McGookey Gardner 2JatrophaWorld Training Programme Slated for India September 20-24, 2010 2JatrophaWorld Training Programme Slated for India September 20-24, 2010 3JatrophaWorld Training Programme Slated for India September 20-24, 2010 4Brown chemists report promising advance in fuel-cell technology 2
(Date:11/18/2014)... -- The Parenteral Drug Association (PDA) today confirmed that seven ... at least seven more will participate in the upcoming 2014 ... in Washington D.C. , Dec. 2-4. ... from the regulatory agencies in the United States ... effort to help advance the use of metrics in the ...
(Date:11/15/2014)... we may still be a few years away from the ... gain instant access to all that ailed his patients, mobile ... for monitoring and measuring our health are cropping up in ... tad Orwellian to some, but a new survey suggests that ... into their healthcare regime. These are some of ...
(Date:11/11/2014)... 2014  Forensicon, Inc., a Chicago ... announce the promotion of Yaniv Schiff from ... In Schiff,s new role as Director, he will lead ... forensics examiners and provide leadership within the company,s digital ... http://photos.prnewswire.com/prnh/20141110/157719 Schiff joined Forensicon in ...
Breaking Biology News(10 mins):FDA's Janet Woodcock, EMA's Emer Cooke Headline PDA Quality Metrics Conference 2Americans May Be Ready for a Brave New World of Healthcare 2Americans May Be Ready for a Brave New World of Healthcare 3Americans May Be Ready for a Brave New World of Healthcare 4Yaniv Schiff Promoted to Director of Digital Forensics at Forensicon, Inc. 2
... SAN DIEGO, Aug. 7 Sony is making the ... DSC-T77 digital,cameras with "intelligent" shooting functions., The 10-megapixel ... 5/8,of an inch with a 3-inch, 16 x 9 ... technology, Smile Shutter(TM) and,face detection technologies with child and ...
... University of Florida College of Pharmacy researchers have discovered ... that inhibits cancer cell growth in laboratory tests, a ... drugs to better battle the disease. The UF-patented ... coral reefs. Researchers, who described results from early studies ...
... Aug. 7, 2008 Despite some improvements to lower ... to do a better job controlling overall blood lipid ... Program study. Researchers found that 37 percent of ... system had reached recommended levels of LDL-C (bad cholesterol), ...
Cached Biology News:Sony Cyber-shot Cameras Get Smarter 2Sony Cyber-shot Cameras Get Smarter 3Researchers find cancer-inhibiting compound under the sea 2Researchers find cancer-inhibiting compound under the sea 3People with heart disease still have trouble controlling blood lipid levels 2
...
...
... to Decorin ( Abpromise for ... Antigen: Synthetic peptide: IGPEVPDDRDFEPS conjugated ... 6-19 of Human Decorin (fragment 36-49 ... II). Entrez GeneID: ...
...
Biology Products: