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Human Genome Sciences Announces Third Quarter 2007 Financial Results and Key Developments

combination with ribavirin. ACHIEVE 2/3 enrolled 933 treatment-naive patients with genotypes 2 and 3 chronic hepatitis C. ACHIEVE 1, the first of the two global Phase 3 trials, completed enrollment of 1331 treatment-naive patients with genotype 1 chronic hepatitis C in August 2007. The Company originally projected completing enrollment of the Phase 3 trials by the end of 2007. HGS expects to have all Phase 3 data available by spring 2009 to support the filing of global marketing authorization applications by fall 2009. Albuferon is being developed by HGS and Novartis under an exclusive worldwide co- development and commercialization agreement entered into in June 2006. HGS received a $40 million milestone payment from Novartis in the third quarter of 2007 for the successful completion of a Phase 2b trial of Albuferon in treatment-naive patients with chronic hepatitis C.

Albuferon requires half as many injections as Pegasys (peginterferon alfa- 2a), the current market leader, and Phase 2 clinical results suggest that Albuferon may offer efficacy at least comparable to Pegasys, with comparable safety and the potential for less impairment of quality of life and daily activity during treatment. HGS believes that Albuferon could become the interferon of choice for the treatment of hepatitis C.

The final results of Phase 2 trials of Albuferon will be presented at the annual meeting of the American Association for the Study of Liver Disease in Boston, November 2-6, 2007.

LymphoStat-B: Enrollment of Phase 3 Trials Progressing

Enrollment of both pivotal Phase 3 trials of LymphoStat-B (belimumab) in patients with active systemic lupus erythematosus (SLE) is progressing. HGS expects to complete enrollment as previously indicated in 2008. LymphoStat-B is being developed by HGS and GSK under a definitive co-development and commercialization agreement entered into in August 2006.

Based on Phase 2 clinical results, HGS believes that LymphoStat-B could

SOURCE Human Genome Sciences, Inc.
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