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Human Genome Sciences Announces Fourth Quarter and Full Year 2007 Financial Results and Recent Progress
Date:2/25/2008

ase 2 Multiple Myeloma Trial Expected by 3rd Quarter

In December 2007, HGS and Aegera Therapeutics Inc. completed a licensing and collaboration agreement providing HGS with exclusive worldwide rights (excluding Japan) to develop and commercialize HGS1029 (formerly AEG40826) and other small-molecule inhibitors of IAP (inhibitor of apoptosis) proteins in oncology. Preclinical studies of HGS1029 in combination with the Company's TRAIL receptor antibodies demonstrated dramatic synergistic activity against a number of cancer types. HGS1029 has also shown significant anti-tumor activity alone and in combination with other agents in a broad range of cancers. HGS expects to initiate a Phase 1 clinical trial of HGS1029 in early 2008 and plans to develop its TRAIL receptor antibodies and IAP inhibitors in combination with one another and in combination with other therapeutic agents.

HGS has completed the enrollment and initial dosing of 105 patients in a randomized Phase 2 trial of HGS-ETR1 in combination with Velcade (bortezomib) in advanced multiple myeloma and expects to have data available in the third quarter of 2008. In December 2007, HGS initiated dosing of patients in a randomized trial of HGS-ETR1 in combination with paclitaxel and carboplatin as first-line therapy in advanced non-small cell lung cancer.

PRODUCTS IN GSK PIPELINE: 2008 A PIVOTAL YEAR

Darapladib: Presentation of Phase 2 Results Expected; 2008 Phase 3 Decision Possible

In GSK's fourth quarter and full-year 2007 results press release on February 7, 2008, GSK stated that the data from its randomized Phase 2 dose- ranging trial of darapladib in patients with coronary artery disease will be presented at the American College of Cardiology meeting in March 2008 - and that the results of GSK's randomized Phase 2/3 imaging trial of darapladib in coronary artery disease have been submitted to a major medical journal.

Darapladib was discovered by GSK based on HGS technolo
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SOURCE Human Genome Sciences, Inc.
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