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Human Genome Sciences Advances Oncology Portfolio
Date:4/16/2008

hts to its TRAIL receptor antibodies, HGS has agreed to a reduction in the royalties to which it is entitled from GSK if Syncria is commercialized. The fees and milestone payments due to HGS under the original Syncria agreement, some of which have already been received, could amount to as much as $183 million and remain unchanged in the amended agreement. Syncria, a novel long-acting form of GLP-1 (glucagon-like peptide-1), was created by HGS using its proprietary albumin-fusion technology. GSK has exclusive rights to develop and commercialize Syncria, and is developing it for use in the treatment of type 2 diabetes. HGS believes it is possible that GSK will reach a decision in 2008 regarding whether to advance Syncria to Phase 3 development.

"We view our oncology portfolio as the cornerstone of our mid-stage pipeline, and as a key driver of future growth beyond the launch of our late- stage products," said Barry A. Labinger, Executive Vice President and Chief Commercial Officer, HGS. "Reacquiring the rights to our TRAIL antibodies gives us the opportunity to drive and advance this growing program. We will continue to explore the possibility of bringing in additional new products, as well as forming new partnerships to add expertise and near-term financial resources in support of our pipeline."

HGS reported that a 2002 agreement with the Pharmaceutical Division of Kirin Brewery Company, Ltd. for joint development of antibodies to TRAIL receptor 2 has also been terminated.

About the HGS-ETR1 Proof-of-Concept Program

HGS-ETR1 is the most advanced of any product in development that targets the TRAIL apoptosis pathway. HGS has advanced HGS-ETR1 to a proof-of-concept phase consisting of three randomized Phase 2 chemotherapy combination trials to evaluate its potential in the treatment of specific cancers:

-- HGS has completed the enrollment and initial dosing of 105 patients in

a randomized Phase 2 trial of HGS-ETR1 in c
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SOURCE Human Genome Sciences, Inc.
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