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Human Genome Sciences Advances Oncology Portfolio
Date:4/16/2008

- HGS reacquires GSK rights to TRAIL receptor antibodies in return for

reduction in Syncria(R) royalties -

- HGS-ETR1 Phase 2 development program expands -

ROCKVILLE, Md., April 16 /PRNewswire-FirstCall/ -- Human Genome Sciences, Inc. (Nasdaq: HGSI) today announced that it has reacquired rights to the TRAIL receptor antibodies HGS-ETR1 (mapatumumab) and HGS-ETR2 (lexatumumab) from GlaxoSmithKline (GSK), in return for a reduction in royalties due to HGS if Syncria(R) (albiglutide) is commercialized. HGS is developing its TRAIL receptor antibodies for the treatment of a broad range of cancers, and announced today that it plans to initiate its third randomized Phase 2 chemotherapy combination trial of HGS-ETR1 by mid-2008 in patients with hepatocellular cancer.

(Logo: http://www.newscom.com/cgi-bin/prnh/20010612/HGSLOGO )

"As our Phase 3 products near commercialization, we are investing strategically to bring our next products forward," said H. Thomas Watkins, President and Chief Executive Officer, HGS. "We are building our oncology portfolio around our leading expertise in the apoptosis pathway. We have added IAP inhibitors, which are highly complementary to our TRAIL receptor antibodies. We have initiated new chemotherapy combination trials of HGS-ETR1, and we have now reacquired the rights to our TRAIL receptor antibodies."

The GSK rights to the TRAIL receptor antibodies resulted from a June 1996 agreement under which HGS granted a 50/50 co-development and co-promotion option to GSK for certain human therapeutic products that complete Phase 2a clinical trials. In exchange for reacquiring the rig
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SOURCE Human Genome Sciences, Inc.
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