Navigation Links
How the cat got his blotches
Date:9/20/2012

As any cat lover knows, distinct patterns of dark and light hair color are apparent not only in housecats but also in their wild relatives, from cheetahs to tigers to snow leopards. Researchers at the HudsonAlpha Institute for Biotechnology and Stanford University, along with colleagues around the world, today reported new genetic findings that help to understand the molecular basis of these patterns in all felines.

A so-called "mackerel tabby" cat has dark tiger stripes, which coalesce into swirls and blotches in a "classic tabby" cat. Like other periodic natural patterns such as stripes on a zebra or spinal bones and vertebra, the origin of these repetitive structures is an unsolved mystery. "Until now, there's been no obvious biological explanation for cheetah spots or the stripes on tigers, zebras or even the ordinary house cat," said Gregory Barsh, M.D., Ph.D., faculty investigator at HudsonAlpha and emeritus professor of genetics at Stanford University, one of the senior authors of the study.

When comparing sequence differences between striped and blotched domestic cats, the researchers saw the evidence pointed to a gene that they named Taqpep. Blotched cats had specific mutations in both copies of this gene, while striped cats did not. Remarkably, the rare "king cheetah," once thought to be a unique species because of an unusual striped pattern rather than regular spots, also carried a mutation in Taqpep.

The team then went on to ask how spots, stripes or blotches form in the first place. "Somehow, cells in the black stripes know they are in a black stripe and remember that fact throughout the organism's life," said Barsh. "We were curious about what's happening at the boundary between light and dark stripes and spots. How do these spots know to grow with an animal?"

Their examination of genes expressed in dark versus light hair cells revealed that patterned markings are due to variations in another gene, Edn3, bein
'/>"/>

Contact: Holly Ralston or Chris Gunter
hralston@hudsonalpha.org
256-508-8954
HudsonAlpha Institute for Biotechnology
Source:Eurekalert

Page: 1 2

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2015)... 30, 2015 AACC welcomed thousands of ... AACC Annual Meeting & Clinical Lab Expo in ... The meeting showcased revolutionary advancements in clinical testing ... healthcare providers to diagnose patients quickly and accurately ... As of Wednesday, July 29, ...
(Date:7/30/2015)... ... , ... The 2015 Market Research Report on the Global Propanol Industry ... Propanol market with a focus on the Chinese situation. Major companies included in the ... Chemical, Sanofi, Royal Dutch Shell, LG Chem and Zhejiang Xinhua Chemical. , The report ...
(Date:7/30/2015)... CITY, Kan. , July 30, 2015 /PRNewswire/ ... ), a pet therapeutics company focused on the ... for companion animals, today announced that its strategic ... from a dose confirmation study of AT-016, an ... Aratana for the treatment of osteoarthritis pain in ...
(Date:7/30/2015)... COPENHAGEN, Denmark , July 30, 2015 /PRNewswire/ ... a biotechnology company that applies its innovative TransCon ... announced positive top-line results from a six-month Phase ... of once-weekly TransCon Growth Hormone in 53 treatment-naïve, ... "We are extremely pleased with the ...
Breaking Biology Technology:Innovative Research on Cancer, Heart Disease, and Infectious Diseases Draws More than 17,500 Attendees to 2015 AACC Annual Meeting 2Innovative Research on Cancer, Heart Disease, and Infectious Diseases Draws More than 17,500 Attendees to 2015 AACC Annual Meeting 3Innovative Research on Cancer, Heart Disease, and Infectious Diseases Draws More than 17,500 Attendees to 2015 AACC Annual Meeting 4Global Propanol Market Technical Data and Manufacturing Analysis 2020 2Global Propanol Market Technical Data and Manufacturing Analysis 2020 3Aratana Therapeutics Announces Positive Pilot Field Study for AT-016 2Aratana Therapeutics Announces Positive Pilot Field Study for AT-016 3Aratana Therapeutics Announces Positive Pilot Field Study for AT-016 4Aratana Therapeutics Announces Positive Pilot Field Study for AT-016 5Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 2Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 3Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 4Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 5Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 6Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 7
... 2011 Today, the Access Group--a leading health care ... of 2 business entities, Promidian and Strategic Selling Solutions ... leaders. The Access Group was formed ... life sciences industries to provide full-service strategy and communications ...
... Diagnostics Incorporated (NYSE: DGX ), the world,s ... test has been approved by New York State,s Department ... state. It is believed to be the first molecular ... to be approved by the state.   ...
... March 17, 2011 Delta Point, Inc., a consulting ... business relationships, has named Ed Weimer as Executive Account ... for his ability to highly motivate, develop and inspire ... strategic vision to contribute to the organization,s goals. ...
Cached Biology Technology:Introducing the Access Group and Its New Business Entities 2Introducing the Access Group and Its New Business Entities 3Introducing the Access Group and Its New Business Entities 4Introducing the Access Group and Its New Business Entities 5Introducing the Access Group and Its New Business Entities 6New York State Approves the Quest Diagnostics ColoVantage™ Colorectal Cancer Blood Test 2New York State Approves the Quest Diagnostics ColoVantage™ Colorectal Cancer Blood Test 3Ed Weimer Joins Delta Point, Inc. as Executive Account Director 2
(Date:7/30/2015)... MOUNTAIN VIEW, Calif. , July 30, 2015 ... products and services for gene function analysis and ... CRISPR Guide RNA (sgRNA) Knockout Library targeting all ... to specifically and permanently "knock out" a gene,s ... library provides a high throughput screening tool so ...
(Date:7/27/2015)... 27, 2015   Zynx Health ™, the ... improvement solutions, today announced that its ZynxCarebook ... on Android smartphones and tablets. With this expansion, ... can use ZynxCarebook to securely exchange messages and ... care transitions to other care settings, and improve ...
(Date:7/23/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/rzzp3v/global_outlook_of ... "Global Outlook of the Biometrics Industry 2015 " ... The global biometrics market is likely to witness ... owing to the uptake of multiple technologies available. ... enhances the growth of biometrics in existing applications ...
Breaking Biology News(10 mins):CELLECTA, INC. Announces Launch of Human Whole Genome CRISPR Knockout Library 2Zynx Health Adds Android Device Support to ZynxCarebook Solution 2Zynx Health Adds Android Device Support to ZynxCarebook Solution 3Global Outlook of the Biometrics Industry 2015 2Global Outlook of the Biometrics Industry 2015 3
... that animals living at high latitudes grow better than ... is more nutritious. The study, published in the February ... novel explanation for Bergmann,s Rule, the observation that animals ... Ever since Christian Bergmann made his observation about latitude ...
... available in Spanish . , Pistachios, almonds and ... a yeast called Pichia anomala . Laboratory and ... (Sylvia) Hua have shown that the yeast competes successfully for ... unwanted mold, Aspergillus flavus . A. ...
... Figs and fig wasps have evolved to help each other ... wasp larvae can safely develop, and in return, the wasps pollinate ... eggs but fails to pollinate the fig? The trees get ... wasps inside, reports a Cornell University and Smithsonian Tropical Research Institute ...
Cached Biology News:Better food makes high-latitude animals bigger 2Trees retaliate when their fig wasps don't service them 2
APO-BrdU™ TUNEL Assay Kit *with Alexa Fluor® 488 anti-BrdU* *60 assays*...
...
IMAGEQUANT 300 IQTL, 1 EA. Category: ImageQuant CCD Imagers....
RayBio Human Cytokine Antibody Array 1.1 (4 array membranes) with Accessory, detects 20 cytokines (for lysate) Class: Antibody Array Products Product Group: Antibody Array...
Biology Products: