Navigation Links
How now, inside the cow: Nearly 30,000 novel enzymes for biofuel production improvements
Date:1/27/2011

cific category of enzymes called carbohydrate-active enzymes (CAZymes) that can break down plant polysaccharides (e.g. cellulose) into small sugars. Hess identified the most promising candidates, tested a subset of 90 candidate genes for functionality and found that more than 50 percent of the tested candidates had cellulose-degrading activity with almost 20 percent able to break down the "real-world" biofuel crop switchgrass. This made it clear to the team that a significant faction of the 30,000 genes identified are indeed active against plant material and would be a treasure trove of novel enzymes for biofuel researchers. Hess said that the discovery of these novel enzymes from this one study significantly increased the number of enzymes believed to act on carbohydrates by nearly a third compared to numerous previous studies carried out over decades.

Besides the identification of genes encoding enzymes that might play a major role in future processes for the industrial production of lignocellulosic biofuel, Hess and Sczyrba wanted to assemble not only genes but the entire genomes of organisms involved in biomass breakdown from the rumen. Using various computational puzzle-solving approaches, they were able to build 15 genomes for the rumen microbes, none of which matched anything that had previously been described.

To confirm their computational results the team turned to another way of examining the genomes of microbes that also did not require a culturing step: single cell genomics involving the study of the genome of a single uncultured microbial cell. They were able to isolate a single rumen microbe using a cell sorter, and without having it grow, they generated the genome of this uncultured microbe using single cell sequencing technology. When the DNA sequences derived from the single genome were mapped to the 15 computationally assembled genomes, the researchers found that more than 98 percent of the data matched to one single genome
'/>"/>

Contact: David Gilbert
degilbert@lbl.gov
925-296-5643
DOE/Joint Genome Institute
Source:Eurekalert  

Page: 1 2 3 4 5

Related biology technology :

1. New nanoscale transistors allow sensitive probing inside cells
2. Researchers take the inside route to halt bleeding
3. Intelligence inside metal components
4. Researchers develop new way to see single RNA molecules inside living cells
5. Horizon Therapeutics Selected to Present at InsideVentures Debut Investor Conference March 25-26, Santa Barbara, California
6. Stem Cell Industry Insider Mercedes Walton Discusses President Obamas Stem Cell Executive Order
7. Targeting Metastatic Cancer From the Inside: Epeius Biotech Reveals a New Generation of Tools for Medical Gene Delivery
8. Reimbursement Rate Nearly Tripled for Cylexs ImmuKnow® Assay
9. NOVAVAX Awarded Nearly $1 Million in Grants from IRS Under Qualifying Therapeutic Discovery Project
10. Combined Sales of Seven Emerging Therapies for Breast Cancer, Including Drugs From Sanofi-Aventis and AstraZeneca, Will Total Nearly $5 Billion by 2019
11. Texcel Medical Expands Medical Device Development & Manufacturing Capabilities With New Personnel, Nearly $1 Million in Capital Investments
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
How now, inside the cow: Nearly 30,000 novel enzymes for biofuel production improvements
(Date:1/22/2015)... | RBJ today announces the firm brokered a long-term lease ... leading biopharmaceutical company, at Two Ledgemont Center in ... , president, and Brian Cohen , senior vice president, ... at 95 Hayden Ave. Photo - http://photos.prnewswire.com/prnh/20150122/170765 ...
(Date:1/22/2015)... 21, 2015 Cambridge Semantics, the leading provider ... announced that 2014 was a record-breaking year across the board ... the Anzo Smart Data Platform and our Smart Data solutions, ... from diverse data which led to record growth for the ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Crystal Diagnostics (CDx) ... that it has received AOAC-PTM Certifications for the six non-O157 ... and O145; collectively referred to as STEC or the “Big-6”) ... colony forming unit (cfu) per 325 g of raw ground ...
(Date:1/22/2015)... Dr. Greg Leyer of UAS Labs recently was ... Pre-Conference seminar on probiotics in San Diego, CA. , ... conference for health care professionals. This year’s pre-conference seminar was ... in health. Dr. Leyer spoke about the emerging topics and ...
Breaking Biology Technology:Transwestern | RBJ Advises Shire in 202,000 SF Lease, Creating Boston's Largest Suburban Biotech Campus 2Cambridge Semantics Announces Record Results for 2014 2Crystal Diagnostics Awarded AOAC-PTM Accreditation for the Rapid Detection of “Big 6” E.coli Food Pathogens 2
... Inc. (Nasdaq: NVAX ) a clinical-stage vaccine company, ... be presenting at the Cowen and Company 29th Annual Healthcare ... at the Boston Marriott Copley Place in Boston, MA. Dr. ... and development progress. A link to the live presentation ...
... YORK, March 13 Jina Ventures is pleased ... Swiss Pharma Contract (SPC) by leading contract research ... Jina Ventures was the exclusive financial advisor ... facilities and services of Basel, Switzerland area-based SPC."We are thrilled ...
... PRINCETON, N.J., March 13 Covance Inc. (NYSE: ... is expanding its clinical pharmacology footprint in Europe ... 50-bed clinical research company based in Basel, Switzerland."Our ... that can help them make decisions faster is ...
Cached Biology Technology:Jina Ventures Advises Swiss Pharma Contract on Strategic Sale to Covance Inc 2Covance Increases Early Clinical Footprint in Europe with Acquisition of Swiss-Based Early Clinical Development Site 2
(Date:12/22/2014)... Dec. 22, 2014 Research and Markets ... the "The Global Watermarking and Fingerprinting Markets" ... http://photos.prnewswire.com/prnh/20130307/600769 This insight ... watermarking and fingerprinting markets. Watermarking aims to control ...
(Date:12/19/2014)... 18, 2014   LaunchKey , the first decentralized mobile ... Internet of Things era, today announced the close of ... was led by Metamorphic Ventures with participation from ENIAC ... and others.  LaunchKey has raised $4 million to date, ...
(Date:12/17/2014)... Dec. 16, 2014 Research and Markets ( ... "Global Chemical Sensor Market 2015-2019" report to their ... One major trend upcoming in this market is ... Chemical sensors help in recording of patient data for ...
Breaking Biology News(10 mins):The Global Watermarking and Fingerprinting Markets 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 3Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2
... Inc., a privately-held company dedicated to maternal and fetal ... nd Annual Meeting of the American Society of ... San Francisco, California. (Logo: http://photos.prnewswire.com/prnh/20120425/SF94380LOGO ) ... access to a blood test that is safe, early ...
... to make cordite, the explosive propellant that replaced gunpowder ... new use in the production of advanced biofuels. With ... U.S. Department of Energy (DOE),s Lawrence Berkeley National Laboratory ... butanol and ethanol from lignocellulosic biomass could be selectively ...
... is a natural battery a chamber filled with ions ... today,s issue of the journal Nature Biotechnology , a ... Infirmary (MEEI) and the Harvard-MIT Division of Health Sciences and ... could power implantable electronic devices without impairing hearing. The ...
Cached Biology News:Verinata Health Announces New Findings At The American Society Of Human Genetics 2More bang for the biofuel buck 2More bang for the biofuel buck 3More bang for the biofuel buck 4Medical devices powered by the ear itself 2Medical devices powered by the ear itself 3
Recombinant Mouse MMP-9, CF...
Viral CMV UL146/vCXC1 Biotinylated Affinity Purified PAb...
Cyan Standard is 7-hydroxy-4-trifluoromethylcoumarin...
... High Sensitivity Freezing Point Osmometer for 10 L sample. Ideal for small volume applications, including pediatric, ... Ready to run in less than 3 minutes after turn-on. ... ... ...
Biology Products: