Navigation Links
How immune cells 'sniff out' bacteria
Date:3/29/2010

Scientists are learning how our immune system senses and tracks down infection in the body by responding to chemical "scents" emitted by bacteria. Studying how immune cells manipulate their movement in response to external signals could shed light not only on how our immune system functions but also how cancer cells spread through the body and even how the brain wires itself.

Speaking at the Society for General Microbiology's spring meeting in Edinburgh, Dr Holger Kress describes a new technique pioneered by himself and Professor Eric Dufresne at Yale University in the US that uses sponge-like micro-particles to mimic bacteria.

The micro-particles slowly release a characteristic bacterial "scent" that is picked up by immune cells, causing them to actively move towards the source of the chemical in an attempt to hunt down the model microbes. These micro-particles can be trapped and manipulated three-dimensionally using 'optical tweezers' highly focussed laser beams that are able to precisely control the movement of the particles to within a millionth of a millimetre. "By controlling the shape of the chemical signals, we were able to control the movements of immune cells and study how they respond to the signals," said Dr Kress.

The scientists found that a single chemical-releasing micro-particle was enough to encourage neutrophils (a type of immune cell) to migrate towards it. Within less than one minute's exposure to the micro-particle, the neutrophils were able to polarize the growth of their internal 'skeleton' in the direction of the chemical.

Dr Kress explained that although researchers had successfully identified the types of chemical signals that stimulate immune cells, it is still a challenge to work out the exact details of the immune cell response. "This new technique allows us to measure systematically how cells respond to various stimuli over minute gradients in time and space."

Dr Kress believes his technique could be applied across a wide range of research fields. "Cell migration along chemical gradients of this kind plays a key role in wound healing and the wiring of the brain. It is also an essential feature of many diseases particularly metastatic cancers," he said.


'/>"/>

Contact: Laura Udakis
l.udakis@sgm.ac.uk
44-118-988-1843
Society for General Microbiology
Source:Eurekalert  

Related biology technology :

1. ImmuneRegen BioSciences Files 8-K that Highlights Enclosed Shareholder Letter Discussing Recent Achievements and Outlook
2. ImmuneRegen Responds to Defense Threat Reduction Agency Request for Information
3. MedImmune Licenses Reverse Genetics Technology to Novartis for Use in Influenza Vaccine Development and Production
4. MedImmune Celebrates Opening of New Pilot Lab at Gaithersburg Headquarters
5. Sanofi Pasteurs Investigational H5N1 Influenza Vaccine Achieves High Immune Response at low Dosage
6. ProImmune Launches New MHC-Peptide Binding Assay for Class II HLA Alleles
7. Advanced Immune Support Formula Licensed From UC Berkeley Launched
8. MedImmune Recognized by Local Volunteer Organization for Its Employees Exceptional Commitment to Community Service within Montgomery County
9. MedImmune to Present RSV Surveillance and Cost-Effectiveness Data at American Academy of Pediatrics National Conference & Exhibition
10. AstraZeneca Bolsters Its Worldwide Biologics Division Through Integration of Cambridge Antibody Technology Into MedImmune
11. MedImmune Announces Seven Key Promotions and New Hires
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
How immune cells 'sniff out' bacteria
(Date:4/27/2016)... ... ... Pittcon Organizing Committee is pleased to announce that Charles “Chuck” Gardner was named president ... Since then, he has served in a number of key leadership positions including secretary ... and exposition committees. In his professional career, Dr. Gardner is the director of product ...
(Date:4/27/2016)... and RESEARCH TRIANGLE PARK, N.C. , ... UTHR ) announced today that Martine Rothblatt ... Therapeutics will provide an overview and update on the ... Annual Health Care Conference. The presentation will ... a.m. Eastern Time, and can be accessed via a ...
(Date:4/27/2016)... ... April 27, 2016 , ... PathSensors, Inc., a ... Board. Dr. Lamka will assist PathSensors in expanding the use of the company’s ... the CANARY® test platform for the detection of harmful pathogens, including a number ...
(Date:4/27/2016)... ... April 27, 2016 , ... Global Stem Cells Group and ... Symposium as other research and development initiatives for potential stem cell protocol management for ... Stem Cells Group executives began meeting to establish a working agenda and foster initiatives ...
Breaking Biology Technology:
(Date:3/10/2016)... March 10, 2016   Unisys Corporation (NYSE: ... Protection (CBP) is testing its biometric identity solution at ... to help identify certain non-U.S. citizens leaving the ... test, designed to help determine the efficiency and accuracy of ... February and will run until May 2016. --> ...
(Date:3/8/2016)... 2016   Valencell , the leading innovator ... has secured $11M in Series D financing. The ... venture fund being launched by UAE-based financial services ... investors TDF Ventures and WSJ Joshua Fund. Valencell ... triple-digit growth and accelerate its pioneering innovation in ...
(Date:3/2/2016)... March 2, 2016 ... addition of the  "Global Biometrics Market in ... ,     (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , , Global biometrics ... at a CAGR of around 27%   ... has announced the addition of the  "Global ...
Breaking Biology News(10 mins):