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Horizon Therapeutics Announces Senior Management Appointments
Date:1/6/2009

nc., which was purchased by Gilead Sciences, Inc. and was most recently vice president of operations at Corus where he was integral in the development and manufacturing of aztreonam lysinate for inhalation (AI). Additionally, he supervised the formulation and development of three additional drug candidates.

Prior to Corus, Mr. Duncan held positions at Pathogenesis Inc. and Lyondell Chemical.

At Horizon, Mr. Duncan will lead all manufacturing, quality control and supply chain activities. Mr. Duncan has a bachelor's degree in biology from Trent University in Ontario, Canada.

The Company recently announced that its lead product HZT-501 met the primary endpoints in two Phase 3 clinical studies, REDUCE-1 and REDUCE-2 (The Registration Endoscopic Study to Determine Ulcer Formation of HZT-501 Compared to Ibuprofen: Efficacy and Safety Study). In REDUCE-1, 24-week treatment with HZT-501 resulted in a statistically significant reduction in gastric ulcers versus treatment with ibuprofen alone. In REDUCE-2, 24-week treatment with HZT-501 resulted in a statistically significant reduction in gastric and/or duodenal ulcers versus treatment with ibuprofen alone.

The trials were conducted via a Special Protocol Assessment (SPA) with the U.S. Food and Drug Administration (FDA) and based on the results the Company plans to submit filings to U.S. and European regulatory authorities in 2009.

About Horizon Therapeutics

Horizon Therapeutics, Inc. is a late-stage biopharmaceutical company focused on the development and commercialization of therapies for the treatment of mild-to-moderate pain and arthritis. Horizon's clinical portfolio includes innovative combination therapies in early- and late-stage development that are designed to improve safety, efficacy and patient compliance. For more information about the company and its products, please visit

SOURCE Horizon Therapeutics, Inc.
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