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HistoRx Receives Key Patent on Application of AQUA(R) Technology to Personalized Medicine
Date:5/12/2010

such as standard immunohistochemistry (IHC). AQUA analysis is used in cancer research by twenty leading academic centers worldwide, is part of the clinical development plans for more than ten drug candidates from major pharma companies, and has been cited in more than 90 peer-reviewed publications.  The first use of AQUA technology in the clinical diagnostic setting is expected later in 2010 with the launch by Genoptix Inc. (Nasdaq: GXDX) of diagnostic tests based on AQUA technology licensed from HistoRx.

"This patent demonstrates AQUA technology's superiority to IHC by quantifying the ratio of TS in two sub-cellular compartments to identify patients who will respond to common first line therapeutics," said Rana K. Gupta, CEO of HistoRx. "Secondly, other TS tests available today are not standardized to give physicians confidence in the biomarker.  AQUA technology is the foundation for the next generation of protein biomarker tests, addressing the clinical need for reliable results and quantifying biomarkers in context of their location."

"The use of a quantitative expression ratio between cellular compartments is a novel approach that is currently only possible with AQUA® technology and can provide enhanced prognostic and predictive information for oncologists treating colon cancer patients," stated one of the inventors, Dr. Mark Gustavson. "In addition, other proteins show differential cellular localization and the use of an expression ratio is applicable for development of other novel biomarkers for predicting outcome or therapeutic response."

About HistoRx, Inc.

HistoRx, Inc. is a leading developer of tissue-based diagnostic solutions to advance indivi
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SOURCE HistoRx, Inc.
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