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HistoRx Receives Key Patent on Application of AQUA(R) Technology to Personalized Medicine
Date:5/12/2010

NEW HAVEN, Conn., May 12 /PRNewswire/ -- HistoRx , Inc., announced today that the U.S. Patent and Trademark Office has granted a patent protecting the company's methods for determining a cancer patient's prognosis based on sub-cellular localization of biomarkers.  U.S. Patent No. 7,709,222 is issued to Yale University and inventors David Rimm, Bob Camp, Mark Gustavson and Greg Tedeschi, and is exclusively licensed to HistoRx.

Use of tissue biomarkers to characterize a patient's cancer is a crucial element of personalized cancer care.  To improve patient survival rates, therapies in the oncology marketplace are being combined with predictive biomarkers to help select patients who will respond to specific drugs. The claims issued in HistoRx's new patent pertain to quantification of thymidylate synthase (TS), a well-known enzyme, in sub-cellular compartments -- that is, the nucleus vs. cytoplasm of tumor cells -- and using the ratio to determine a patient's prognosis and responsiveness to specific treatments. The results from this test can be used to prescribe currently available therapeutics, making the test immediately relevant to oncologists.   

The invention was only possible through the use of HistoRx's proprietary AQUA® technology to quantify TS in cellular compartments of tumor cells from patients with colon cancer.  AQUA technology is an automated, quantitative IHC testing method that enables measurement of protein biomarkers in tissue as an aid to a pathologist's diagnosis.  Such precise determination of first, the location within the tumor cell and second, the amount in each location is not possible with conventional testing methods,
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SOURCE HistoRx, Inc.
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