Navigation Links
HistoRx Licenses Melanoma Assay from Yale University
Date:12/21/2011

BRANFORD, Conn., Dec. 21, 2011 /PRNewswire/ -- HistoRx recently licensed from Yale University a new clinical diagnostic assay based on AQUA® technology.  This assay enables doctors treating patients with melanoma to identify a subset of those patients who, despite having no detectable cancer in their lymph nodes, have a 40% risk of recurrence of their disease.  AQUA technology is an automated, quantitative IHC testing method that enables measurement of protein biomarkers in tissue as an aid to a pathologist's diagnosis.  Such precise determination of first, the location within the tumor cell and second, the amount in each location is not possible with conventional testing methods, such as standard immunohistochemistry (IHC). 

The prognostic assay was developed in the laboratory of David Rimm, MD, PhD, inventor of AQUA technology and Professor of Pathology, Director of Pathology Tissue Services at the Yale School of Medicine, and may be useful in guiding treatment decisions for Stage II, node-negative melanoma patients.  "After surgical resection of the tumor, if the nodes are negative, we don't have much more to offer," said Dr. Rimm.  "This assay allows us to measure the risk of recurrence which can be helpful to ease patient anxiety or to prompt patients to be aggressive in follow up or even consider adjuvant chemotherapy."  

There are five biomarkers analyzed in the assay, and the amounts of each were measured in total and in the separate compartments of nucleus and cytoplasm.  Results are interpreted to delineate clearly between low-risk and high-risk patients; Dr. Rimm intentionally avoided creating an intermediate category which is not helpful to physician decision making.  The study is described in Dr. Rimm's 2009 article in the Journal of Clinical Oncology (v. 27, n. 34, pp. 5772 – 5780) which concludes that the assay is 'an independent determinant of melanoma surviva
'/>"/>

SOURCE HistoRx, Inc.
Copyright©2010 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2

Related biology technology :

1. Metamark and HistoRx Announce Licensing Agreement for AQUA® Technology
2. Jack Davis, Diagnostics Industry Executive, Joins the HistoRx Board of Directors
3. Heiner Dreismann, Ph.D., Former President of Roche Molecular Systems, Joins the HistoRx Board of Directors
4. HistoRx Receives Key Patent on Application of AQUA(R) Technology to Personalized Medicine
5. Genoptix and HistoRx Announce Licensing Agreement for AQUA(R) Technology
6. HistoRx Names Dick Carroll, Ph.D. as VP of Clinical Research
7. Roche Licenses Nanopore Sequencing Technologies from Arizona State University and Columbia University for Rapid, Affordable DNA Sequencing
8. CMC Biologics Licenses Its CHEF1® Expression System to Oxford BioTherapeutics
9. Eppendorf Licenses Technology for Thermal Cyclers to Bulldog Bio
10. Amsterdam Molecular Therapeutics Licenses Additional Novel Gene Therapy Vectors from National Institutes of Health
11. EdeniQ Licenses Yeast Technology from USDA
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/16/2013)... May 16, 2013 Scientists at the Center ... , and the California -based ... a novel therapy for reversing memory decline in mice ... find significant cognitive improvement in advanced stage AD mice. ... for reversing cognitive decline for advanced stage AD mice, ...
(Date:5/16/2013)... 16, 2013 Reportlinker.com announces ... is available in its catalogue: ... Analysis: Therapeutic Proteins – Biosimilars, Biobetters ...   Product ... The new Competitive Intelligence Report Therapeutic ...
(Date:5/16/2013)... ON (PRWEB) May 16, 2013 DNA Genotek, ... announced ‘Spit for Africa’, a sponsorship program in conjunction with ... is designed to improve access and reduce the cost of ... projects such as the Human Heredity and Health in Africa ... the AfSHG. , The aim of the AfSHG ...
(Date:5/16/2013)... York, NY (PRWEB) May 16, 2013 ... Insights: Market Access Success for Companion Diagnostic–Drug Pairings ... key issues that biopharmaceutical manufacturers should understand when ... is gaining traction, particularly in oncology, with two ... and Zelboraf for BRAF-mutation positive melanoma. Payors are ...
Breaking Biology Technology:Elevation of Brain Magnesium Reverses Memory Deficits in Alzheimer Mice 2Elevation of Brain Magnesium Reverses Memory Deficits in Alzheimer Mice 3Competitor Analysis: Therapeutic Proteins - Biosimilars, Biobetters & Biosuperiors 2Competitor Analysis: Therapeutic Proteins - Biosimilars, Biobetters & Biosuperiors 3Competitor Analysis: Therapeutic Proteins - Biosimilars, Biobetters & Biosuperiors 4Competitor Analysis: Therapeutic Proteins - Biosimilars, Biobetters & Biosuperiors 5Competitor Analysis: Therapeutic Proteins - Biosimilars, Biobetters & Biosuperiors 6Competitor Analysis: Therapeutic Proteins - Biosimilars, Biobetters & Biosuperiors 7Competitor Analysis: Therapeutic Proteins - Biosimilars, Biobetters & Biosuperiors 8DNA Genotek Inc. Announces Spit for Africa Program 2DNA Genotek Inc. Announces Spit for Africa Program 3Market Access Expert Firm, PRMA Consulting, Launches Companion Diagnostics Handbook 2
... Micromet, Inc. (Nasdaq: MITI ), a ... treatment of cancer, inflammation and autoimmune diseases, today ... Journal of Immunotherapy (1) demonstrating the potent anti-tumor ... antigen (CEA) and to CD3 on T cells. ...
... Scientists have designed tiny new sensor structures that could ... and explosives, or in highly sensitive medical sensors, according ... Letters . , The new ,nanosensors, which are ... and US research groups, could be tailor-made to instantly ...
... Impact Systems, video is chosen as a finalist in the International ... ... Greenville, DE (PRWEB) April 7, 2009 -- Impact Systems ... (ECM) software tools and services, today announced their Compliance-in-a-Box video has ...
Cached Biology Technology:Pre-Clinical Data on CEA-specific BiTE Antibody Published in Journal of Immunotherapy Demonstrate Potent Control of Tumor Growth 2Pre-Clinical Data on CEA-specific BiTE Antibody Published in Journal of Immunotherapy Demonstrate Potent Control of Tumor Growth 3Pre-Clinical Data on CEA-specific BiTE Antibody Published in Journal of Immunotherapy Demonstrate Potent Control of Tumor Growth 4New security and medical sensor devices made possible by metallic nanostructures 2Impact Systems' Compliance-in-a-Box™ Video is Announced as "Be the Buzz of Bio" Contest Finalist 2Impact Systems' Compliance-in-a-Box™ Video is Announced as "Be the Buzz of Bio" Contest Finalist 3
(Date:5/16/2013)... use of genome-wide analysis (GWA), where the entirety of ... genomic mutations or variants which can cause health problems ... However, it can also pose major ethical problems if ... of Human Genetics (ESHG) published on line today (16 ... Genetics ., Many services based on whole genome and ...
(Date:5/16/2013)... and the manager of San Diego Zoo Global,s Central ... award. The Whitley award is an international competition ... celebrates the extraordinary achievements of some of the world,s ... selected for the award due to his efforts to ... wildlife inhabitants., HRH The Princess Royal, the charity,s patron, ...
(Date:5/16/2013)... NEW YORK , May 16, 2013 ... market research report is available in its ... Market Forecast & Opportunities, 2018 ... data protection and old security practises such ... driven the growth of biometric technologies in ...
Breaking Biology News(10 mins):European Society of Human Genetics urges caution over use of new genetic sequencing techniques 2Cameroon researcher wins prestigious 'Green Oscar' 2Cameroon researcher wins prestigious 'Green Oscar' 3Global Biometric Systems Market Forecast & Opportunities, 2018 2Global Biometric Systems Market Forecast & Opportunities, 2018 3Global Biometric Systems Market Forecast & Opportunities, 2018 4Global Biometric Systems Market Forecast & Opportunities, 2018 5Global Biometric Systems Market Forecast & Opportunities, 2018 6Global Biometric Systems Market Forecast & Opportunities, 2018 7
... with basic scientists from the University of California, Irvine ... for normal development of the reproductive, olfactory and circadian ... report to appear in the Proceedings of the National ... gene called PROK2 (prokineticin 2) in human siblings with ...
... mind,s growth -- but it does not have to stop ... of adult monkeys. A team of neuroscientists has ... at which new neural cells form in the hippocampus region ... associated with both learning and memory. While other research groups ...
... service, developed in the framework of an ESA-supported project, ... across Europe in order to ensure the more efficient ... European Union (EU) must be registered with the national ... (EPPO), which requires efficiency data derived from field trials. ...
Cached Biology News:Study identifies pathway required for normal reproductive development 2Study identifies pathway required for normal reproductive development 3Brain cell growth diminishes long before old age strikes, animal study shows 2
...
IHC detection kit for BrdU in cells and tissues...
The Hybrid Hunter Yeast Two-Hybrid System uses the activation of reporter genes to indicate positive protein-protein interactions. Two reporters are used an auxotrophic marker and lacZ....
Request Info...
Biology Products: