Navigation Links
HistoRx Licenses Melanoma Assay from Yale University
Date:12/21/2011

BRANFORD, Conn., Dec. 21, 2011 /PRNewswire/ -- HistoRx recently licensed from Yale University a new clinical diagnostic assay based on AQUA® technology.  This assay enables doctors treating patients with melanoma to identify a subset of those patients who, despite having no detectable cancer in their lymph nodes, have a 40% risk of recurrence of their disease.  AQUA technology is an automated, quantitative IHC testing method that enables measurement of protein biomarkers in tissue as an aid to a pathologist's diagnosis.  Such precise determination of first, the location within the tumor cell and second, the amount in each location is not possible with conventional testing methods, such as standard immunohistochemistry (IHC). 

The prognostic assay was developed in the laboratory of David Rimm, MD, PhD, inventor of AQUA technology and Professor of Pathology, Director of Pathology Tissue Services at the Yale School of Medicine, and may be useful in guiding treatment decisions for Stage II, node-negative melanoma patients.  "After surgical resection of the tumor, if the nodes are negative, we don't have much more to offer," said Dr. Rimm.  "This assay allows us to measure the risk of recurrence which can be helpful to ease patient anxiety or to prompt patients to be aggressive in follow up or even consider adjuvant chemotherapy."  

There are five biomarkers analyzed in the assay, and the amounts of each were measured in total and in the separate compartments of nucleus and cytoplasm.  Results are interpreted to delineate clearly between low-risk and high-risk patients; Dr. Rimm intentionally avoided creating an intermediate category which is not helpful to physician decision making.  The study is described in Dr. Rimm's 2009 article in the Journal of Clinical Oncology (v. 27, n. 34, pp. 5772 – 5780) which concludes that the assay is 'an independent determinant of melanoma surviva
'/>"/>

SOURCE HistoRx, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2

Related biology technology :

1. Metamark and HistoRx Announce Licensing Agreement for AQUA® Technology
2. Jack Davis, Diagnostics Industry Executive, Joins the HistoRx Board of Directors
3. Heiner Dreismann, Ph.D., Former President of Roche Molecular Systems, Joins the HistoRx Board of Directors
4. HistoRx Receives Key Patent on Application of AQUA(R) Technology to Personalized Medicine
5. Genoptix and HistoRx Announce Licensing Agreement for AQUA(R) Technology
6. HistoRx Names Dick Carroll, Ph.D. as VP of Clinical Research
7. Roche Licenses Nanopore Sequencing Technologies from Arizona State University and Columbia University for Rapid, Affordable DNA Sequencing
8. CMC Biologics Licenses Its CHEF1® Expression System to Oxford BioTherapeutics
9. Eppendorf Licenses Technology for Thermal Cyclers to Bulldog Bio
10. Amsterdam Molecular Therapeutics Licenses Additional Novel Gene Therapy Vectors from National Institutes of Health
11. EdeniQ Licenses Yeast Technology from USDA
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/14/2014)... Communications, a leading provider of strategic communications services to corporations and ... the United States and Europe ... JD, is returning to the firm,s Washington, D.C. ... more than two years of service as Associate Commissioner for the ...
(Date:1/14/2014)... , Jan. 14, 2014 The largest international ... medicinal plants and therapeutic derivatives thereof has endorsed ... and researchers about the challenges of adulterated herb ... ) The Society for Medicinal ...
(Date:1/14/2014)... Canada (PRWEB) January 14, 2014 In ... its motives and methods in product development and promotion ... the industry. This mistrust, fueled by concerns about the ... fed by reports of spectacular fines to the world’s ...
(Date:1/14/2014)... Kinaxis ®, provider of RapidResponse ®, a cloud-based supply ... ( S&OP ) service, is proud to be a gold ... held at the Hilton San Diego Bayfront, January 30 – ... Kaszas , Director of Supply Chain at Amgen, as she ...
Breaking Biology Technology:Former FDA Associate Commissioner Returns To 3D Communications 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 3World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 4World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 5World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 6World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 7World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 8The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 2The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 3Event Alert: Kinaxis Customer to Present at the Biomanufacturing Summit "Supply Chain: Improving Network Effectiveness" 2
... news for the global effort to reduce the amount of ... technologies that rely upon the piezoelectric effect. A lead-free alternative ... by researchers with the U.S. Department of Energy,s Lawrence Berkeley ... Berkeley. The key to this success is the use ...
... TAI,AN CITY, China, Nov. 13 ... ("China Biologic," or the "Company"),one of the leading plasma-based ... host a conference call at 8:00 a.m. ET on,Monday, ... financial results,ended on September 30, 2009. , ...
... Soligenix, Inc., (Soligenix or the Company) (OTC ... Inc., a late-stage biotechnology company, announced today its ... , Highlights and Recent Developments: ... confirmatory Phase 3 randomized, double-blind, placebo-controlled, multicenter clinical ...
Cached Biology Technology:Berkeley researchers take the lead out of piezoelectrics 2Berkeley researchers take the lead out of piezoelectrics 3China Biologic Schedules Conference Call to Discuss Third Quarter 2009 Financial Results 2Soligenix Reports Third Quarter 2009 Financial Results 2Soligenix Reports Third Quarter 2009 Financial Results 3Soligenix Reports Third Quarter 2009 Financial Results 4Soligenix Reports Third Quarter 2009 Financial Results 5
(Date:4/17/2014)... University of Texas Medical Branch at Galveston are ... with radiation for cervical cancer should begin colorectal ... The UTMB researchers, finding a high incidence of ... with radiation, offer new recommendations that the younger ... about eight years after their initial cervical cancer ...
(Date:4/17/2014)... Scientists have uncovered a new way the immune system ... aid efforts to use immune cells to treat illness. ... have the immunological equivalent of "neighborhood police" specialized ... single organ, instead of an entire city, the body. ... St. Louis have shown that the liver, skin and ...
(Date:4/17/2014)... of The Proceedings of the National ... 29, raises a number of startling questions about a ... take for granted. At the end of the last ... shifted from hunting animals and gathering fruits and tubers ... straightforward and yet the more scientists learn, the more ...
Breaking Biology News(10 mins):Radiation therapy for cervical cancer increases risk for colorectal cancer 2Some immune cells defend only 1 organ 2Genetic study tackles mystery of slow plant domestications 2Genetic study tackles mystery of slow plant domestications 3Genetic study tackles mystery of slow plant domestications 4
... PUYALLUP, Wash.A Washington State University toxicologist has found ... butterfly populations., The research was aimed at possible ... in northern California, but it has implications for ... used, says John Stark, an ecotoxicologist and director ...
... ago, marine scientists made a startling discovery in the deep ... water surges from the seafloor and life thrives without sunlight. ... areas where methane rises from seeps on the ocean bottom. ... living side-by-side? No one thought so. Until now. ...
... , The National Institute of Standards and Technology (NIST) ... the federal government,s Natural Resources Damage Assessment (NRDA) in ... spill 40 miles off the Louisiana coast. The new ... 2779), will be used as a quality control material ...
Cached Biology News:Commonly used herbicides seen as threat to endangered butterflies 2Hot meets cold at new deep-sea ecosystem: 'Hydrothermal seep' 2NIST releases Gulf of Mexico crude oil reference material 2
... Panels were designed for full-length gene cloning ... to identify the desired cDNA clone. The ... 96-well "Master Plate," where each well contains ... the positive well(s) by gel electrophoresis of ...
... The CEQ 8800 Genetic Analysis System, which ... This automated system adds a higher level ... The CEQ 8800, part of Beckman Coulters new ... coding link with the Biomek series liquid handers, ...
... cDNA Library Panels were designed for full-length ... of PCRs to identify the desired cDNA ... in a 96-well "Master Plate," where each ... Having identified the positive well(s) by gel ...
... cDNA Library Panels were designed for full-length ... of PCRs to identify the desired cDNA ... in a 96-well "Master Plate," where each ... Having identified the positive well(s) by gel ...
Biology Products: