Navigation Links
Highly lethal Ebola virus has diagnostic Achilles' heel for biothreat detection, scientists say
Date:4/5/2013

By screening a library of a billion llama antibodies on live Ebola viruses in the Texas Biomedical Research Institute's highest biocontainment laboratory, scientists in San Antonio have identified a potential weakness in the make-up of these deadly agents that can immediately yield a sensitive test.

"Detecting single viral protein components can be challenging, especially at very low levels. However, most viruses are repetitive assemblies of a few components, called antigens, with some existing as polymers which present highly 'avid' targets for antibodies," said Texas Biomed virologist Andrew Hayhurst, Ph.D.

"Think of one pair of microscopic Velcro hooks where one hook is the viral antigen and the other is the antibody and it is a weak interaction. Have a thousand pairs of hooks and it makes a very powerful interaction just like Velcro fasteners on hiking gear," Hayhurst explained.

The screening performed by Hayhurst and assistant Laura Jo Sherwood guided the selection of llama antibodies recognizing a polymer hiding within Ebola called nucleoprotein (NP). Remarkably, each antibody could be used in its own right to form a sensitive test for the Ebola NP, whereas most tests would require two different antibodies driving up costs and characterization times.

This research -- funded by National Institutes of Health (NIH), Defense Threat Reduction Agency Basic Science Program/Office of Naval Research and the Texas Biomedical Research Institute -- was published today in the journal PLOS ONE.

"Ebola NP is rather like a cob of corn displaying hundreds of kernels linked in a repetitive polymer, giving us the perfect molecular magnet to attract llama antibodies that can be assembled into highly avid assays based on a single antibody," Hayhurst said.

"Intriguingly, while using one antibody to polymers and aggregates has been put to use in neurodegenerative disease diagnostics for Parkinson's, Alzheimer's and other disorders, it ha
'/>"/>

Contact: Joseph Carey
jcarey@txbiomed.org
210-258-9437
Texas Biomedical Research Institute
Source:Eurekalert

Page: 1 2

Related biology technology :

1. Highly efficient production of advanced biofuel by metabolically engineered microorganism
2. Researchers create highly conductive and elastic conductors using silver nanowires
3. Stanford engineers perfecting carbon nanotubes for highly energy-efficient computing
4. UCLA team develops highly efficient method for creating flexible, transparent electrodes
5. Ebola antibody treatment, produced in plants, protects monkeys from lethal disease
6. DiaCarta Inc. Receives CE Mark for QuantiVirus® HPV E6/E7 mRNA Assay
7. Acne Treatment Brand, Probiotic Action, Comments on the Use of a Virus to Treat Acne
8. New Norovirus "Vomiting Virus" Strain Spreads Like Wildfire, My Cleaning Products Publishes Green Guide to Prevent Norovirus Outbreaks in One's Home
9. Viruses cooperate or conquer to cause maximum destruction
10. Inovio Pharmaceuticals Cytomegalovirus (CMV) Synthetic Vaccine Constructs Generate Strong and Broad T-Cell Responses in Preclinical Study
11. When parasites catch viruses
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/3/2015)... Aug. 3, 2015  Merck KGaA, Darmstadt, ... top-quality high-tech products in the healthcare, life science and ... company Nano-C, their development and launch of promising new ... (OPV). Merck KGaA, Darmstadt, Germany , ... OPV sector. Novel derivatives: highly stable, easy ...
(Date:8/3/2015)... 3, 2015 According to a ... Cell Culture: Asia to Witness ... the global 3D cell culture market was valued at US$ 586.1 ... a CAGR of 29.1% to account for US$ 2,717.6 ... TOC:  http://www.persistencemarketresearch.com/market-research/3d-cell-cultures-market.asp 3D cell culture refers ...
(Date:7/31/2015)... July 31, 2015 China Cord Blood Corporation ... leading provider of cord blood collection, laboratory ... services, today announced that the Company has filed its ... and Exchange Commission. The filed Form 20-F includes audited ... 2015. The Form 20-F can be accessed by visiting ...
(Date:7/30/2015)... TX, USA (PRWEB) , ... July 30, 2015 ... ... and microsystems, has appointed Francois Vieillard as Sales & Marketing Director. , ... positions, Francois Vieillard will be responsible for reinforcing Tronics’ business development activities worldwide. ...
Breaking Biology Technology:Merck KGaA, Darmstadt, Germany, and Nano-C Present Enhanced Materials for Organic Photovoltaics 2Merck KGaA, Darmstadt, Germany, and Nano-C Present Enhanced Materials for Organic Photovoltaics 3Merck KGaA, Darmstadt, Germany, and Nano-C Present Enhanced Materials for Organic Photovoltaics 4Global 3D Cell Culture Market Will Reach US$ 2,717.6 Million by 2020: Persistence Market Research 2Global 3D Cell Culture Market Will Reach US$ 2,717.6 Million by 2020: Persistence Market Research 3Global 3D Cell Culture Market Will Reach US$ 2,717.6 Million by 2020: Persistence Market Research 4China Cord Blood Corporation Files Its Annual Report on Form 20-F 2Tronics appoints Francois Vieillard as Sales and Marketing Director 2
... Wound Ambulance Established in Monterrey, MONTERREY, Mexico, ... and Sangui BioTech GmbH,executives jointly opened another wound ... the occasion of a three day working visit. ... Marketing,Representative Renate Pentzien discussed the next steps of ...
... D.C. -- The biological pathway that powers sperm ... devices, releasing drugs or performing mechanical functions inside the ... for Cell Biologys 47th Annual meeting. , The ... Health may be the first demonstration of how multistep ...
... of children and adolescents in U.S. may have high blood ... ... epidemic(2,3), - Diovan has a proven safety profile in adults ... (valsartan), an,angiotensin receptor blocker or ARB, has been approved following a priority,review ...
Cached Biology Technology:Sangui Partnership Enters a New Phase: 2Sangui Partnership Enters a New Phase: 3Sangui Partnership Enters a New Phase: 4Tethered to chip, energy supply that drives sperm could power 'nanobot' 2FDA Approves Diovan(R) for Treatment of High Blood Pressure in Children 2FDA Approves Diovan(R) for Treatment of High Blood Pressure in Children 3FDA Approves Diovan(R) for Treatment of High Blood Pressure in Children 4FDA Approves Diovan(R) for Treatment of High Blood Pressure in Children 5
(Date:7/13/2015)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... on the growing mobile commerce market, announced today ... BEHAVIORAL-DIRECTED AUTHENTIATION METHOD AND SYSTEM. ... method to make payments.  With this patent, NXT-ID ... its groundbreaking voice-direct payment patent application, with behavior-directed ...
(Date:7/9/2015)... , July 9, 2015  Synaptics ... developer of human interface solutions, today announced ... industry,s first fully hardware encapsulated fingerprint sensor ... authentication technology is literally off the grid, ... biometric matching within the fingerprint sensor to ...
(Date:7/8/2015)... 8, 2015 The consumer products industry ... must have products such as wearables, smart wallets & other ... biometrics based devices continues to rapidly grow.  Biometrics & Wearable ... NXTD ), Google Inc. (NASDAQ: GOOG ), Apple Inc. ... GoPro, Inc. (NASDAQ: GPRO ) and Baidu Inc. (NASDAQ: ...
Breaking Biology News(10 mins):NXT-ID Patents Behavior-Directed Payments 2NXT-ID Patents Behavior-Directed Payments 3NXT-ID Patents Behavior-Directed Payments 4Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 2Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 3Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 2Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 3Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 4Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 5Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 6
... approval of Baraclude (entecavir) tablets and oral solution for ... hepatitis B is a serious disease caused by the ... virus can cause lifelong infection, cirrhosis (scarring) of the ... the Centers for Disease Control and Prevention, approximately 1.25 ...
... study by researchers at the University of California, Berkeley, ... promoting cleaner, more efficient technologies for producing charcoal in ... climate change and development benefits. , The African continent, ... Latin America, is dependent on both wood and charcoal ...
... solved the structure of a critical piece of synapse-associated protein ... where it is believed to play a role in everything ... The Journal of Biological Chemistry. , Dale Mierke, associate professor ... piece of SAP97 is built is an important step. Now ...
Cached Biology News:Study of energy and health in Africa focuses spotlight on charcoal and forest management 2Study of energy and health in Africa focuses spotlight on charcoal and forest management 3Researchers reveal secret of key protein in brain and heart function 2
Arginine vasopressin receptor (AVP-V2), rat. The peptide used for immunization has no significant similarity with AVP V1a or V1b receptors....
... Immunogen: Goats were immunized ... Antibody was isolated by affinity chromatography using ... anti- human T7 affinity purified antibodies were ... method. Specificity: Antibody ...
Insect Cell Lysis Buffer 50 ml...
Ubiquitin-like protein 4A (Ubiquitin-like protein GDX). [Source:Uniprot/SWISSPROT;Acc:P11441] Antigen: Recombinant Protein Epitope Signature Tag (PrEST)....
Biology Products: