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Highly efficient production of advanced biofuel by metabolically engineered microorganism
Date:10/25/2012

of target bioproducts.

Butanol has been used as an important industrial solvent, and is also a great alternative fuel because of its similar properties to gasoline. It can also be blended with gasoline at any ratio. Butanol is naturally produced by some anaerobic bacteria, but the efficiency of its production could not match that of ethanol due to the high toxicity of butanol to host organisms and the production of byproducts such as acetone and organic acids. Over the past decades, many research groups extensively studied clostridial butanol producing organisms to achieve higher yield and titer, but the limited genetic modification tools and complex metabolic pathways of clostridia hampered the successful development of an engineered strain capable of producing butanol at a higher yield and titer.

The Korean research team analyzed metabolic pathways leading to butanol production and found that two different solvent-forming pathways can be potentially employed. In one pathway, butanol is directly produced from carbon source, which was termed as hot channel, and in the other, butanol is converted from the acids produced earlier in fermentation process, which was termed as cold channel. Using the in silico modeling and simulation tools, Professor Lee's team demonstrated that the hot channel allowed a much better approach to produce butanol compared with the cold channel. To reinforce a metabolic flux toward the hot channel for butanol production, the metabolic network of C. acetobutylicum strain was systematically engineered.

In addition, the downstream process was optimized and an in situ recovery process was integrated to achieve higher butanol titer, yield, and productivity. The combination of systems metabolic engineering and bioprocess optimization resulted in the development of a process capable of producing more than 585 g of butanol from 1.8 Kg of glucose, which allows the production of this important industrial solvent and a
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Contact: Lan Yoon
hlyoon@kaist.ac.kr
82-423-502-295
The Korea Advanced Institute of Science and Technology (KAIST)
Source:Eurekalert

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