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Cyclic increases in replikin concentration in the genome can be a mechanism of expansion of an infectious organism into a territory. In other examples, the replikin concentration of West Nile Virus was earlier found to increase annually through two distinct cycles as the virus expanded in the U.S.: the first from 2000 to 2003, and the second from 2004 to 2007 (p less than 0.001). Increases in the annual number of CDC reported human cases followed each of the virus replikin concentration increases. Similar correlations also have been shown for replikin concentrations and human mortality in an influenza H5N1 cycle between 1997 and 2007.
Over the last 10 years, malaria has accounted for more than 10 million
deaths worldwide -- by comparison, over the same period the H5N1 (Bird Flu)
virus has been responsible for less than 300 human deaths. Consistent with
the high replikin counts found in this study, trypanosomes have one of the
highest replication rates in nature. This property may account in part for
the resistance of malaria to previous attempts at vaccination. The
discovery of the relation of the replikins to rapid replication offers a
new approach, and the means, to inhibit rapid replication and limit
mortality in malaria.
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Replikins Ltd., 38 The Fenway, Boston, MA 02215
email: sbogoch@replikins.com
Tel: 646-320-5910
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