BOSTON, May 19 /PRNewswire/ -- Replikins Ltd. has found that very high concentrations of its replikin genetic sequences are found in the trypanosomes that are the infectious agents in malaria. The levels found by the company are in fact the highest replikin concentrations observed to date in any infectious disease agent. The company has also found that these concentrations cycle over several years.
Replikins appear to be possible agents or promoters of infectivity, host morbidity and mortality. Timely repeated analyses of cyclic changes in an organism's replikin structure may be useful to bring current the targets for the chemical synthesis of ReplikinBestFit(TM) vaccines. These strain-specific vaccines, manufactured in 7 days, were recently shown to protect 91% of shrimp against the lethal Taura Syndrome Virus.
To obtain the current malaria results, publicly-available protein sequence data on Pl. Falciparum, the most common strain in malaria, were gathered from the Pubmed online listing, and examined against World Health Organization data on human malaria deaths for each year between 1986 and 2007. The quantitative replikin concentration (Replikin Count(TM) = number of replikins per 100 amino acids) examined by automated FluForecast(R) software found those areas of the trypanosome genome which have the highest replikin concentrations (Replikin Peak Genes(TM)).
Two instances of cyclical behavior were revealed in the trypanosome:
the first cycle occurred from 1986 to 1995, and the second from 1996 to
2005. The peak of the first cycle, in 1987, with a Replikin Count(TM) of
38.2 +/-23.5, was followed by a higher peak in the next cycle, in 1999, of
62.9+/-63, exceeding 100 by overlap; both peaks were related to higher
human mortality. Counts declined after the 1999 high to a low in 2005 of
7.4+/-6.5; and a decreased mortality rate followed between 2000 and 2005. A
third malaria replikin cycle appears to have begun in 2007 with the
|SOURCE Replikins Ltd.|
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