OTTAWA, Ontario, March 14, 2013 /PRNewswire/ -- A group of lethal bacteria are of increasing concern worldwide because they are becoming resistant to many or all of the antibiotics previously effective against them (1). Bioradar UK Ltd. announced today in Ottawa, Canada that it has discovered that the concentration of genomic Replikins is markedly increased in antibiotic-resistant bacteria. This finding is permitting a new approach to the problem of antibiotic resistance.
The specific change in the Replikins genomic structure of the Replikins provides a novel target: proprietary Replikins Synthetic Vaccines like those found effective against H5N1 influenza in poultry and lethal Taura Syndrome virus in shrimp, have been formulated, and which are now available for testing against lethal antibiotic-resistant Gonococcus, Tuberculosis, Staphylococcus, Streptococcus, Klebsiella KPC, and Cl. Difficile.
For example, in Replikin Analysis of antibiotic-sensitive-Gonococcus, in all 5,110 genomic sequences on Pubmed, the percent of the gonococcus population with Replikin®Counts above 4.0 is only 3%; but in antibiotic-resistant-Gonococcus, the percent in the gonococcus genome with Replikin®Counts greater than 4.0 increased to 95% in tetracycline-resistant Gonococcus (Figure).
In Cl. Difficile, in sequences from 86,581 specimens, the percent of Replikin®Counts greater than 4.0 was found to increase from approximately 30% in the year 2000 to 45.6% in 2007 and has remained at that level to 2012. Similar data were obtained in Staphylococcus, with 86% above a Count of 4.0 in 2006, and in Streptococcus, with 65% above a Count of 4.0 in 2009 (2).
When an association of genomic Replikins was first observed in Tuberculosis (3), there was no reason
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