Navigation Links
High-strength silk scaffolds improve bone repair
Date:4/30/2012

MEDFORD/SOMERVILLE, Mass. (April 30, 2012, 3 PM EDT) -- Biomedical engineers at Tufts University's School of Engineering have demonstrated the first all-polymeric bone scaffold material that is fully biodegradable and capable of providing significant mechanical support during repair. The new technology uses micron-sized silk fibers to reinforce a silk matrix, much as steel rebar reinforces concrete. It could improve the way bones and other tissues are repaired following accident or disease.

The discovery is reported in the Proceedings of the National Academy of Sciences Online Early Edition the week of April 30-May 4, 2012.

In the U.S. an estimated 1.3 million people undergo bone graft surgeries each year, notes the paper.

Human bones are hard but relatively lightweight, able to withstand considerable pressure while being sufficiently elastic to withstand moderate torsion. Inside the hard, mineralized tissue is a matrix in which bone cells can proliferate and adhere. Natural bone is the obvious choice for grafts.

However autologous grafts mean putting the patient through additional surgery and the supply of self-donated tissue is, obviously, limited. Donor grafts pose risks of disease, graft rejection and other long-term complications.

A handful of all-polymeric biomaterials, such as collagen, are currently used for bone regeneration, but they lack strength. Incorporating ceramics or metals into polymers improves mechanical properties but such composites often sacrifice optimum bone remodeling and regeneration.

By bonding silk protein microfibers to a silk protein scaffold, the Tufts bioengineers were able to develop a fully biodegradable composite with high-compressive strength and improved cell responses related to bone formation in vitro.

The study found that silk microfiber-protein composite matrices mimicked the mechanical features of native bone including matrix stiffness and surface roughness that enhanced human mesenchymal stem cell differentiation compared to control silk sponges. In combination with inherent silk fiber strength, compact fiber reinforcement enhanced compressive properties within the scaffolds.

"By adding the microfibers to the silk scaffolds, we get stronger mechanical properties as well as better bone formation. Both structure and function are improved," said David Kaplan, Ph.D., chair of biomedical engineering at Tufts University. "This approach could be used for many other tissue systems where control of mechanical properties is useful and has broad applications for regenerative medicine."

Other authors on the paper were Biman B. Mandal, former post doctoral associate in the Department of Biomedical Engineering at Tufts and now in the Department of Biotechnology, Indian Institute of Technology; visiting biomedical engineering student Ariela Grinberg, who recently completed her degree in the Department of Tissue Engineering, Cell Therapy and Regenerative Medicine at the National Institute of Rehabilitation, Mexico; and Eun Seok Gil and Bruce Panilaitis, research associate and research assistant professor respectively in the Department of Biomedical Engineering at Tufts.

The Tufts scientists used a novel approach to manufacturing the silk microfibers: applying alkaline hydrolysis (the use of alkali chemicals to break down complex molecules into their building blocks). This greatly reduced the time and cost of making the microfibers in a variety of sizes. Microfibers ranging from 10 to 20 um were obtained in one minute, compared with production of 100 um plus size fibers after 12 minutes of conventional processing.

Although significant improvements in compressive properties were observed in the silk composite scaffolds, values were still significantly lower than that of stronger native bone. The Tufts researchers suggest that such scaffolds can play a valuable role as temporary biodegradable support for native cells to grow and replace.


'/>"/>

Contact: Kim Thurler
kim.thurler@tufts.edu
617-627-3175
Tufts University
Source:Eurekalert

Related biology technology :

1. Self-assembling polymer arrays improve data storage potential
2. Beaumont Doctors Invention Improves Cataract Surgery Outcomes
3. Early-Bird Registration Ends this Week for 10th Annual Quality Excellence Conference: How Process Improvement Leaders Produce Profits in Recessions
4. Carilion Clinic Invests in Sight Saving Technology to Improve Patient Care: Carilion Clinic Teams Up with Retasure
5. Germicidal UVC Lights Improve Clinical Pregnancy Rates for IVF Lab, New Study Finds
6. Sanofi Aventis : New Study Results Support the "Basal Plus" Strategy With LANTUS(R) and APIDRA(R) to Improve Blood Sugar Control in Patients With Type 2 Diabetes
7. Enobia Pharma Presents PreClinical Data Showing ENB-0040 Significantly Improved Survival and Healed Skeletal Manifestations of Severe Hypophosphatasia in Mice
8. Global Psychiatrists Unite to Improve Services in Mental Health
9. Kelly Osbourne and International Health Groups Call for Improved Education on Choices and Usage of Contraception
10. Commonwealth Care Alliance Selects Casenet To Unify Patient Information and Improve Care for Massachusetts Members
11. Finesse Solutions Launches Improved E-Store for Sensors and Transmitters
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/18/2017)... ... January 18, 2017 , ... Opal Kelly, a leading ... PCI Express, announced the ZEM5310 USB 3.0 FPGA Module, combining a SuperSpeed USB ... sized form factor suitable for prototyping, testing, and production-ready integration. The ZEM5310 USB ...
(Date:1/18/2017)... , Jan. 18, 2017   Boston Biomedical ... compounds designed to target cancer stemness pathways, will feature ... compound, napabucasin, at the 2017 ASCO Gastrointestinal Cancers Symposium, ... . Napabucasin is an orally-administered ... targeting STAT3. i Cancer stem cells (CSCs) possess ...
(Date:1/18/2017)... 2017   Parent Project Muscular Dystrophy (PPMD) , ... Duchenne muscular dystrophy (Duchenne) , today announced a $600,000 ... of Technology (NJIT) and Talem Technologies (Talem) as part ... to assist people living with Duchenne. PPMD is ... an embedded computer, software, a force sensor and a ...
(Date:1/18/2017)... (PRWEB) , ... January 18, 2017 , ... ... that Dr. Dante Leven successfully implanted SpineFrontier’s A-CIFT™ Solofuse-P™. The operation took place ... in Valley Stream, NY. The procedure was an anterior cervical discectomy and fusion ...
Breaking Biology Technology:
(Date:12/22/2016)... December 22, 2016 SuperCom (NASDAQ: ... solutions for the e-Government, Public Safety, HealthCare, and Finance sectors announced ... has been selected to implement and deploy a community-based supportive services ... Northern California , further expanding its presence in the state. ... This new program, ...
(Date:12/19/2016)... España y TORONTO , 19 de diciembre de ... Biologics Inc. que permitirá el desarrollo acelerado de MSC-1, un anticuerpo ... varios tipos de tumor en 2017, con múltiples sitios previstos a ... ... con objetivo en el factor inhibidor de leucemia (LIF), una citoquina ...
(Date:12/16/2016)... 2016 The global wearable medical device market, in terms ... from USD 5.31 billion in 2016, at a CAGR of 18.0% ... ... advancements in medical devices, launch of a growing number of smartphone-based ... among healthcare providers, and increasing focus on physical fitness. ...
Breaking Biology News(10 mins):