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Henry Ford Hospital and Rosetta Genomics to Develop MicroRNA-based Diagnostics for Brain Cancer
Date:1/14/2008

Davidson Laboratory of Cell Signaling & Tumorigenes and neuro-oncologist Dr. Mikkelsen is co-director of the Hermelin Brain Tumor Center. "A significant advantage of using microRNAs as biomarkers, is that they do not degrade when the tumor sample is stored as an FFPE block. As FFPE blocks can be stored at room temperature, these sample types are readily available and allow us to conduct retrospective studies. Through these studies, we can identify microRNA diagnostic and prognostic biomarkers, such as for disease staging, response to treatment, and risk of recurrence. Combining Rosetta Genomics' proprietary technologies for microRNA research and its experience in this field with our expertise in brain cancer is a good starting point for this important project."

About MicroRNAs

MicroRNAs (miRNAs) are recently discovered, naturally occurring small RNAs that act as master regulators and have the potential to form the basis for a new class of diagnostics and therapeutics. Since many diseases are caused by the abnormal activity of proteins, the ability to selectively regulate protein activity through microRNAs could provide the means to treat a wide range of human diseases. In addition, microRNAs have been shown to have different expression in various pathological conditions. As a result, these differences may provide for a novel diagnostic strategy for many diseases.

About Henry Ford Hospital

Henry Ford Hospital is a 903-bed tertiary care hospital, education and research complex in Detroit's New Center Area. The Hermelin Brain Tumor Center at Henry Ford Hospital focuses on brain and spine tumors and is considered one of the largest neuro-oncology centers in the nation. It also houses one of the most comprehensive brain tumor research labs and biorepository in the country. The Center continues to focus on novel investigations to help control brain tumor growth and spread, including molecular targeted therapy; gene therapy and anti-angiogenesi
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