Navigation Links
HemaQuest Pharmaceuticals Presents Promising Results in Sickle Cell Disease and Beta Thalassemia
Date:12/8/2009

K-1001

HQK-1001 belongs to a class of compounds originally discovered at Boston University School of Medicine and licensed to the Company. These compounds, designated as Short Chain Fatty Acid Derivatives (SCFADs), have been shown to stimulate fetal globin expression and red blood cell production in the laboratory and in small clinical trials in patients with hemoglobin disorders, including sickle cell disease and beta thalassemia. HQK-1001 is an orally administered SCFAD, which has shown an excellent safety profile and biologic effects on fetal globin induction and red blood cell production in the laboratory, relevant animal models, and in healthy human subjects in Phase 1 clinical trials. Additionally, the compound has received Orphan Drug Designation in the United States and Europe for both sickle cell disease and beta thalassemia.

ABOUT SICKLE CELL DISEASE AND BETA THALASSEMIA

Sickle cell disease is a genetic disorder affecting the beta globin chain of adult hemoglobin, which results in distorted, rigid sickle red blood cells, which block blood vessels, causing lack of oxygen to tissues, acute episodes of pain (pain crises), lung injury (acute chest syndrome), and strokes. Infections are common, and chronic damage occurs in many organs, including the spleen, bones, kidneys, lungs, brain, and eyes. The sole drug which is approved to treat the disease is a cancer chemotherapy drug, hydroxyurea. The lifespan of sickle cell patients is markedly reduced in the U.S., where there are approximately 75-80,000 patients.

Beta thalassemias are among the most common genetic blood disorders worldwide, in which patients are unable to produce normal amounts of the beta globin chain of adult hemoglobin, with consequent rapid destruction of red blood cells and their progenitors, and moderate to severe, transfusion-dependent anemia. The standard therapies are transplantation and red blood cell transfusions, which cause iron overload an
'/>"/>

SOURCE HemaQuest Pharmaceuticals
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3

Related biology technology :

1. Merrimack Pharmaceuticals Acquires Hermes Biosciences, Inc.
2. Access Pharmaceuticals Provides Update on MuGard Commercial Launch in Europe
3. VIA Pharmaceuticals Completes Patient Visits in Phase 2 Trial of VIA-2291
4. Peregrine Pharmaceuticals to Report Second Quarter FY 2010 Financial Results
5. China Yongxin Pharmaceuticals Inc. to Distribute Medicines on the Essential Drug List
6. KTA Capital Arranges an AU$6.7 Million Private Placement by Neuren Pharmaceuticals
7. Arena Pharmaceuticals to Present at the Piper Jaffray 21st Annual Health Care Conference
8. Peregrine Pharmaceuticals Presents Promising Antiviral Data at 2009 Chemical and Biological Defense Science & Technology Conference
9. Onyx Pharmaceuticals to Present at the Credit Suisse 18th Annual Healthcare Conference
10. Optimer Pharmaceuticals Reports Third Quarter 2009 Financial Results
11. ISTA Pharmaceuticals Reports Third Quarter 2009 Financial Results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... New Rochelle, N.Y. (PRWEB) August 21, 2014 ... it is the first private college in the Mid-Hudson ... The College will now begin accepting applications from qualified ... , “We are very pleased to have been ... to support Governor Cuomo’s transformative initiative to stimulate economic ...
(Date:8/21/2014)... NEW YORK , Aug. 21, 2014 /PRNewswire/ ... OTCM) congratulates Immune Pharmaceuticals Inc., a biotechnology company, ... Capital Market.  Immune previously traded on OTCQX®, the ... operated by OTC Markets Group. Logo - ... Immune Pharmaceuticals on the successful execution of its ...
(Date:8/21/2014)... 21, 2014 Pursuit Solutions ( ... technology and services for Life Sciences sales and ... Use of New Commercial Sales Models” by Peter ... , The article examines some innovative models used ... being tested in the pharmaceutical market. Robinson grades ...
(Date:8/21/2014)... SoundConnect , a unified communication ... of the nation’s Fastest Growing Private Companies by ... consecutive year. Inc. magazine today ranked SoundConnect NO. ... exclusive ranking of the nation's fastest-growing private companies. ... the most important segment of the economy—America’s independent ...
Breaking Biology Technology:The College of New Rochelle Becomes First Private College in Mid-Hudson Region to Earn START-UP NY Designation 2The College of New Rochelle Becomes First Private College in Mid-Hudson Region to Earn START-UP NY Designation 3OTC Markets Group Congratulates Immune Pharmaceuticals on NASDAQ Listing 2Pursuit's Peter Robinson Publishes "Grading Pharma's Use of New Commercial Sales Models" 2SoundConnect Returns on Inc. 5000 List of Fastest Growing Companies 2SoundConnect Returns on Inc. 5000 List of Fastest Growing Companies 3
... biometrics company enabling applications for the real ... with Methode Electronics, Inc. One of the ... being a solid Tier 1 automotive supplier ... devices. Together, Methode and Lumidigm will bring ...
... ... alternatives, WALTHAM, Mass., Aug. 5 ... Company is focusing its,day-to-day operations exclusively on obtaining financing or consummating ... Company,s employees were released from employment, except,for Shawn Cain, the Company,s ...
... to Curb Unsafe Sex and Drug, Use ... Response, MEXICO CITY, Aug. 5 In a ... calls on global leaders to aggressively,expand HIV prevention programs ... use. Citing hundreds of clinical trials and,observational studies, the ...
Cached Biology Technology: Lumidigm Signs Strategic Agreement with Methode Electronics : Automotive Supplier Invests in Biometric Component Development 2Arbios Announces It Has Suspended Operations 2Arbios Announces It Has Suspended Operations 3Arbios Announces It Has Suspended Operations 4Arbios Announces It Has Suspended Operations 5Leading AIDS Experts Urge Greater Focus on Behavior-Change Programs to Prevent HIV 2Leading AIDS Experts Urge Greater Focus on Behavior-Change Programs to Prevent HIV 3Leading AIDS Experts Urge Greater Focus on Behavior-Change Programs to Prevent HIV 4
(Date:8/21/2014)... A new study of American singles found that ... the highest orgasm rates. On average, men experience ... sexual orientation making little difference. For women, however, ... experience orgasm 62.9 percent of the time during ... pattern varies with women,s sexual orientation, with lesbian ...
(Date:8/21/2014)... linked to dandruff, eczema and other itchy, flaky maladies ... global reachesincluding Hawaiian coral reefs and the extreme environments ... review in the scientific journal PLOS Pathogens ... of the genus Malassezia in light of ... around the world. , University of Hawai,i at Mānoa ...
(Date:8/21/2014)... a finding that has implications for life in other ... the solar system, LSU Associate Professor of Biological Sciences ... Science Foundation, or NSF, this week published a paper ... that lies 800 meters (2600 feet) beneath the surface ... ecosystems.", Given that more than 400 subglacial lakes and ...
Breaking Biology News(10 mins):Orgasm rates for single women less predictable than men's, vary by sexual orientation 2Orgasm rates for single women less predictable than men's, vary by sexual orientation 3Orgasm rates for single women less predictable than men's, vary by sexual orientation 4From dandruff to deep sea vents, an ecologically hyper-diverse fungus 2800 meters beneath Antarctic ice sheet, subglacial lake holds viable microbial ecosystems 2800 meters beneath Antarctic ice sheet, subglacial lake holds viable microbial ecosystems 3800 meters beneath Antarctic ice sheet, subglacial lake holds viable microbial ecosystems 4
... tomorrow at NJIT from 8:30 a.m. - 4 p.m. ... secure schools, health and transportation facilities, protect customs, borders ... Presenters will include NJ State Police, Customs ... and Preparedness, U.S. Coast Guard and NJ Department of ...
... The discovery of a protein involved in the life-threatening ... the Florida State University College of Medicine attract a ... Branko Stefanovic, associate professor in the department of ... discovery could lead to treatment methods that may stem ...
... available in German . A group ... for Infection Research (HZI) in Braunschweig points out a ... myxobacteria, the substances prevent an enzym of the pathogens ... this way, the propagation of bacteria such as ...
Cached Biology News:FSU researcher's discovery leads to $1.5 million grant, potential new treatment of liver fibrosis 2New antibiotic candidates from Braunschweig 2New antibiotic candidates from Braunschweig 3
geminin, DNA replication inhibitor...
Normal human serum, single donor...
One-step, microplate or cuvet, colorimetric, linear detection range 0.1 mg/dL to 100 mg/dL. Procedure: 20 min....
... Certified USDA Research Registered OLAW Assured AAALAC ... AALAS Certified Technicians Documentation ... Upon Request Focus CRP is ... your custom immunology service needs. We ...
Biology Products: