Navigation Links
Heart disease: Research off the beating patch
Date:7/20/2009

TUCSON, ARIZ. It is an amazing sight: What looks like a tiny beating heart is actually a piece of synthetic, gauze-like mesh, barely the size of a fingernail, floating in a Petri dish. And yet it keeps squeezing away, nice and rhythmically.

Researchers at The University of Arizona's Sarver Heart Center and the Southern Arizona Veterans Administration Health Care System (SAVAHCS) have come a step closer to repairing hearts damaged by a heart attack or weakened by chronic heart failure.

"We have developed a delivery system that allows us to introduce living, healthy heart muscle cells into damaged areas of the heart in a way that is much more efficient than the conventionally practiced method of injecting cells into heart tissue," says study leader Steven Goldman, MD.

Unlike most existing approaches, in which cardiac cells with no supporting structure are injected into heart tissue, Goldman's group uses a patch (Theregen Inc. San Francisco) made from microscopically thin fibers that serve as a scaffold to which the cells can adhere.

The group's latest achievements have attracted the attention of the American Heart Association, who picked the research as one of the most noteworthy achievements of this year's Cardiovascular Sciences Annual Conference in Las Vegas, Nev.

"Ultimately, we hope to use our system in patients with chronic heart failure and, possibly, to prevent heart failure in patients who had a heart attack," says Jordan Lancaster, BS, a pre-doctoral fellow in Dr. Goldman's lab who will present the research at the meeting on July 21, 2009.

Dr. Goldman and his team discovered that when they "seed" a vicryl mesh patch with a sufficiently large number of heart muscle cells (2.5 million or more), the cells start behaving just like their counterparts in the real organ: They contract synchronously at about 70 beats per minute even without any outside stimulation.

"Our work shows that we can put living cells onto a biodegradable, 3-dimensional scaffold in a way that not only allows them to survive, but to spontaneously beat in a coordinated fashion," says Lancaster.

In addition to demonstrating the feasibility of using a synthetic mesh as a means to deliver living heart cells into a diseased heart, the group has already shown that the patch improves left ventricular function and blood flow when implanted into damaged heart muscle in a rat model of myocardial infarction.

Dr. Goldman believes that the construct developed in his lab provides a better vehicle to introduce cells into damaged heart muscle than conventional cell transplantation techniques, in which cells are injected directly into the heart.

"I think the main reason for the disappointing results people have seen with those clinical trials is that the cells end up in an environment that is not optimal for them to thrive in. Scar tissue offers poor blood supply and weak structural support for new cells to attach, survive and grow. Our patch offers just what cardiac muscle cells need: structural support, increased blood supply and chemicals secreted by the supporting cells on the patch that help the heart muscle cells grow and function."


'/>"/>

Contact: Ann Cisneros
ann@u.arizona.edu
520-626-7237
University of Arizona Health Sciences Center
Source:Eurekalert  

Related biology technology :

1. Thoratec Announces HeartMate II(R) PMA Will be Reviewed by FDA Advisory Panel
2. ATS Medical Expands Open Pivot Heart Valve Offerings
3. Cardicas C-Port(R) Flex A Anastomosis System Allows Surgeons to Perform Revolutionary Closed-Chest Heart Bypass Surgeries
4. Signalifes Dr. Harmison Launches Award-Winning Ambulatory Heart Monitor
5. Cleveland Clinic-Led Research Uncovers New Mechanism That Heightens Risk of Heart Disease
6. New Licence for Cubicin(R) (daptomycin), the First in a Novel Class of Antibiotic, is Announced Today for the Treatment of Serious Bloodstream and Heart Infections Caused by the Most Problematic UK Organisms, Including MRSA
7. Panel to Discuss the Far-Ranging Effects and Consequences of Heart Disease, Which is the Leading Killer in Both Men and Women in the United States
8. Cheetah Medicals NICOM Non-Invasive Cardiac Output Monitor Featured in a Presentation at the Heart Failure Society of America (HFSA) Annual Meeting
9. New Study Shows Promise for Hydrogen Sulfide in Reducing Heart-Attack Damage, Ikaria Announces
10. Americas Heartland Launches Third Season Highlighting Contributions of American Farmers and Ranchers
11. CV Therapeutics Announces Presentations at American Heart Association Scientific Sessions 2007
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Heart disease: Research off the beating patch
(Date:5/23/2017)... ... 2017 , ... Bacterial biofilms, surface adherent communities of bacteria that are encased ... food poisoning and catheter infections to gum disease and the rejection of medical implants. ... dollars per year, there is currently a paucity of means for preventing their formation ...
(Date:5/22/2017)... (PRWEB) , ... May 22, 2017 , ... ... today that it is exhibiting in booth B2 at the Association for ... May 22-25. , In addition to demonstrating its Cancer Diagnostic Cockpit and ...
(Date:5/18/2017)... ... May 18, 2017 , ... Dr. Ralph ... at the Prince Of Wales Private Hospital. The procedure was performed on a ... patient failed conservative treatments prior to undergoing surgery. , The AxioMed viscoelastic disc ...
(Date:5/18/2017)... ... May 17, 2017 , ... Cognition Corporation ... has just released version 9.0 of the Cognition Cockpit platform. , “Our whole ... says David Cronin, CEO of Cognition. “We’re thrilled to finally be able to ...
Breaking Biology Technology:
(Date:3/24/2017)... , Mar 24, 2017 Research and Markets ... System Market Analysis & Trends - Industry Forecast to 2025" ... ... grow at a CAGR of around 15.1% over the next decade ... industry report analyzes the market estimates and forecasts for all the ...
(Date:3/23/2017)... 23, 2017 Research and Markets has announced ... & Trends - Industry Forecast to 2025" report to their ... The ... CAGR of around 8.8% over the next decade to reach approximately ... the market estimates and forecasts for all the given segments on ...
(Date:3/22/2017)... March 21, 2017 Optimove , ... by retailers such as 1-800-Flowers and AdoreMe, today ... Recommendations and Replenishment. Using Optimove,s machine learning algorithms, ... product and replenishment recommendations to their customers based ... predictions of customer intent drawn from a complex ...
Breaking Biology News(10 mins):