TUCSON, ARIZ. It is an amazing sight: What looks like a tiny beating heart is actually a piece of synthetic, gauze-like mesh, barely the size of a fingernail, floating in a Petri dish. And yet it keeps squeezing away, nice and rhythmically.
Researchers at The University of Arizona's Sarver Heart Center and the Southern Arizona Veterans Administration Health Care System (SAVAHCS) have come a step closer to repairing hearts damaged by a heart attack or weakened by chronic heart failure.
"We have developed a delivery system that allows us to introduce living, healthy heart muscle cells into damaged areas of the heart in a way that is much more efficient than the conventionally practiced method of injecting cells into heart tissue," says study leader Steven Goldman, MD.
Unlike most existing approaches, in which cardiac cells with no supporting structure are injected into heart tissue, Goldman's group uses a patch (Theregen Inc. San Francisco) made from microscopically thin fibers that serve as a scaffold to which the cells can adhere.
The group's latest achievements have attracted the attention of the American Heart Association, who picked the research as one of the most noteworthy achievements of this year's Cardiovascular Sciences Annual Conference in Las Vegas, Nev.
"Ultimately, we hope to use our system in patients with chronic heart failure and, possibly, to prevent heart failure in patients who had a heart attack," says Jordan Lancaster, BS, a pre-doctoral fellow in Dr. Goldman's lab who will present the research at the meeting on July 21, 2009.
Dr. Goldman and his team discovered that when they "seed" a vicryl mesh patch with a sufficiently large number of heart muscle cells (2.5 million or more), the cells start behaving just like their counterparts in the real organ: They contract synchronously at about 70 beats per minute even without any outside stimulation.
"Our work shows that we can pu
|Contact: Ann Cisneros|
University of Arizona Health Sciences Center