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Harvard's Wyss Institute models a human disease in an organ-on-a-chip
Date:11/7/2012

gn of the lung-on-a-chip to demonstrating its potential to model a complex human disease, which we believe provides a glimpse of what drug discovery and development might look like in the future," Ingber says.

The cross-disciplinary, multi-institutional team that was led by Ingber and Huh also included Wyss Postdoctoral Fellow Daniel Leslie, Ph.D.; Benjamin Matthews, M.D., assistant professor of pediatrics in the Vascular Biology Program at Boston Children's Hospital and Harvard Medical School; Wyss Institute Researcher Jacob Fraser; Samuel Jurek, a researcher at Boston Children's Hospital and Harvard Medical School; Senior Wyss Staff Scientist Geraldine Hamilton, Ph.D.; and Senior Scientific Investigator Kevin Thorneloe, Ph.D., and Investigator M. Allen McAlexander from GlaxoSmithKline. Ingber is also the Judah Folkman Professor of Vascular Biology at Harvard Medical School and Boston Children's Hospital, and Professor of Bioengineering at Harvard School of Engineering and Applied Sciences.

"Organs-on-a-chip represents a new approach to model the structure, biology, and function of human organs, as evidenced by the complex breathing action of this engineered lung. This breathing action was key to providing new insight into the etiology of pulmonary edema," said Dr. James M. Anderson, M.D., Ph.D., director of the NIH Division of Program Coordination, Planning, and Strategic Initiatives that provided partial support for this research through the Common Fund's Regulatory Science program. "These results provide support for the broader use of such microsystems in studying disease pathology and hopefully for identifying new therapeutic targets."


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Contact: Kristen Kusek
kristen.kusek@wyss.harvard.edu
617-432-8266
Wyss Institute for Biologically Inspired Engineering at Harvard
Source:Eurekalert  

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Harvard's Wyss Institute models a human disease in an organ-on-a-chip
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