Navigation Links
Harvard's Wyss Institute models a human disease in an organ-on-a-chip
Date:11/7/2012

l of the lung-on-a-chip, fluid leaked across the membrane and two tissue layers, reducing the volume of air in the other channel and compromising oxygen transportjust as it does in lungs of human patients when it is administered at the equivalent doses and over the same time course. Blood plasma proteins also crossed into the air channel, leading to the formation of blood clots in the air space, as they do in humans treated with IL-2.

But one result came as a surprise.

It turns out the physical act of breathing greatly enhances the effects of IL-2 in pulmonary edema --"something that clinicians and scientists never suspected before," Ingber says. When the team turned on the vacuum attached to the chip to simulate breathing, it increased fluid leakage more than three-fold when treated with the clinically relevant IL-2 dose, and the Wyss team confirmed that the same response occurs in an animal model of pulmonary edema. This result could suggest that doctors treating patients on a respirator with IL-2 should reduce the tidal volume of air being pushed into the lungs, for example, in order to minimize the negative side effects of this drug.

Most exciting for the future of drug testing was the Wyss team's finding that "this on-chip model of human pulmonary edema can be used to identify new potential therapeutic agents in vitro," Ingber says. The pulmonary edema symptoms in the lung-on-a-chip disease model could be prevented by treating the tissues with a new class of drug, a transient receptor potential vanilloid 4 (TRPV4) channel blocker, under development by GlaxoSmithKline (GSK). In a separate study published by the GSK team in the same issue of Science Translation Medicine, the beneficial effects of TRPV4 inhibition in reducing pulmonary edema were independently validated using animal models of pulmonary edema caused by heart failure.

"In just a little more than two years, we've gone from unveiling the initial desi
'/>"/>

Contact: Kristen Kusek
kristen.kusek@wyss.harvard.edu
617-432-8266
Wyss Institute for Biologically Inspired Engineering at Harvard
Source:Eurekalert  

Page: 1 2 3

Related biology technology :

1. Harvards Wyss Institute creates living human gut-on-a-chip
2. Masaryk Memorial Cancer Institute Reduces Losses and Administrative Overhead With Ekahau RTLS
3. Van Andel Institute Partners with UNCF to Recruit Students to Biomedical Research Careers
4. The Pharmabiotic Research Institute (PRI) is Preparing to Publish its First Works on the Therapeutic and Medicinal Potential of Probiotics
5. Michael A. Marletta Takes Office as New President of Scripps Research Institute
6. HealthCare Institute of New Jersey Releases 2011 Biopharmaceutical and Medical Technology Economic Impact Data
7. QIAGEN and Max Planck Institute for Infection Biology Collaborate to Develop Assay for Active TB Risk in Individuals With Latent Infection
8. DFH Pharma to Collaborate With National Cancer Institute to Develop Second-Generation HIV Maturation Inhibitor Drugs
9. Niels Bohr Institute gets top researcher from Harvard
10. Van Andel Research Institute Study Provides New Details of Fundamental Cellular Process
11. Lupus Research Institute Awards $3.6 Million for Novel Studies Driving Wide-Ranging New Science in Lupus
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Harvard's Wyss Institute models a human disease in an organ-on-a-chip
(Date:7/23/2014)... 23, 2014  Having the right people at the ... accelerating business growth and achieving clinical and operational goals. ... Leadership Summit, July 20-22, 2014, in San ... executives and healthcare experts discussing how partnerships have positively ... President & Chief Executive Officer of Cape Regional Medical ...
(Date:7/23/2014)... DES MOINES, Iowa (PRWEB) July 23, 2014 ... will join the business as vice president of Agricultural ... from Mendel Biotechnology where he served most recently as ... brings extensive biotechnology and business leadership in the seed ... DuPont Pioneer,” said Paul E. Schickler , president ...
(Date:7/23/2014)... 23, 2014  GrowBLOX Sciences, Inc. (OTCQB: GBLX), a medical ... filing for two medical marijuana dispensary locations in ... to the Clark County, Nevada dispensary ... as previously announced.  GrowBLOX Sciences, CEO Craig ... new applications for dispensaries in the City of ...
(Date:7/23/2014)... (PRWEB) July 23, 2014 OncLive® ... Cancer Center has joined its Strategic Alliance Partnership ... Alliance Partnership program, UNC Lineberger will have the ... raise awareness of its cutting-edge research initiatives, community-directed ... UNC Lineberger will work with OncLive to educate ...
Breaking Biology Technology:MSC and Cape Regional Medical Center Partner to Improve Cost, Quality and Outcomes 2DuPont Pioneer Names Neal Gutterson to Lead Agricultural Biotechnology 2DuPont Pioneer Names Neal Gutterson to Lead Agricultural Biotechnology 3GrowBLOX Sciences, Inc. Files for Two Additional Medical Marijuana Dispensaries in Las Vegas 2GrowBLOX Sciences, Inc. Files for Two Additional Medical Marijuana Dispensaries in Las Vegas 3OncLive Expands Its Strategic Alliance Partnership Program With the Addition of UNC Lineberger Comprehensive Cancer Center 2OncLive Expands Its Strategic Alliance Partnership Program With the Addition of UNC Lineberger Comprehensive Cancer Center 3
... , SAN FRANCISCO, Dec. 1 Medizone International, ... tests involving its proprietary AsepticSure(TM) technology, it continues to ... very different spore forming bacteria, Claustridium difficile and Bacillis ... potent sporicidal technology. "The implications of a 6.7 log ...
... ... comprehensive training programs, including biomedical repair technologies. Their shared efforts will begin in 2010 ... ... the recent signing of a Memorandum of Understanding, Mercy Ships and MediSend International have ...
... Cambridge, Mass November 30, 2009 An ... Photonics, and ETH Zrich have demonstrated compact, multibeam, ... of the light spectrum (infrared). By contrast, typical ... well-defined wavelength. The innovative multibeam lasers have potential ...
Cached Biology Technology:Medizone International Takes Aim at the Bioterrorism Countermeasures Arena 2Mercy Ships and MediSend International Partner to Deliver Hope and Healing 2Mercy Ships and MediSend International Partner to Deliver Hope and Healing 3Scientists demonstrate multibeam, multi-functional lasers 2
(Date:7/23/2014)... New Rochelle, NY -- The potential for clinical ... for transplant-based therapeutic strategies has previously been hindered ... the development of tumors. The ability to use ... for the treatment of heart disease, specifically acute ... Stem Cells and Development , a peer-reviewed ...
(Date:7/23/2014)... BCC Research ( ... MARKETS AND TECHNOLOGIES FOR SENSORS , the global market ... to nearly $154.4 billion by 2020, with a five-year ... flow, and level sensors segment is moving at a ... ) , Sensors have become indispensable to ...
(Date:7/23/2014)... . , Animals ... which might be very different from ours. Some bird ... sunlight in the atmosphere to calibrate their orientation systems. ... in Seewiesen, Germany, and Queen,s University Belfast have discovered ... the greater mouse-eared bat, has the capability to orient ...
Breaking Biology News(10 mins):Global Market for Sensors to Reach Nearly $154.4 Billion in 2020; Image Sensors Moving at 11.7% 2Global Market for Sensors to Reach Nearly $154.4 Billion in 2020; Image Sensors Moving at 11.7% 3Bats use the evening sky's polarization pattern for orientation 2
... has uncovered a protein that plays a vital role in ... in improving the production and quality of crops and biofuels. ... PNAS . The team included researchers from Dartmouth, ... Plant roots use their endodermis, or inner skin, as a ...
... Frederick will present new research at the 108th Annual ... and women,s beliefs about who should pay for dates ... expenses. The paper, Who Pays for Dates? Following versus ... than 17,000 participants; a quarter of whom also provided ...
... Vision licensee, Theresa Ayers , has added a second location ... Ronald Ayers , the husband-and-wife team assumed ownership last month ... Theresa Ayers has been with Pearle Vision, one of ... for more than three decades. She began her career working for ...
Cached Biology News:Research on which gender pays for dates shows change and resistance from convention 2Local Pearle Vision Licensee Adds Second Center In Canton, Ohio 2Local Pearle Vision Licensee Adds Second Center In Canton, Ohio 3Local Pearle Vision Licensee Adds Second Center In Canton, Ohio 4Local Pearle Vision Licensee Adds Second Center In Canton, Ohio 5
... of 2D polyacrylamide gel electrophoresis (2D-PAGE) with ... a core technology platform for proteomic analysis. ... complex samples limited only in the dynamic ... large proteins. Quantitative image based analysis of ...
...
... use in Refrigerated Vapor Trap Models RVT100, ... (UVS) Models UVS400, UVS400A and UVS800DDA., A ... for use for temperatures ranging from -105 ... thermal stability and does not evaporate. Far ...
... 10X Automation Buffer is a concentrated formulation ... autostainers employing capillary action technology, as well ... in collaboration with David Brigati M.D., Department ... OK. This buffer is recommended for all ...
Biology Products: