Navigation Links
Harvard's Wyss Institute develops DNA nanorobot to trigger targeted therapeutic responses
Date:2/16/2012

ach was modeled on the body's own immune system in which white blood cells patrol the bloodstream for any signs of trouble. These infection fighters are able to hone in on specific cells in distress, bind to them, and transmit comprehensible signals to them to self-destruct. The DNA nanorobot emulates this level of specificity through the use of modular components in which different hinges and molecular messages can be switched in and out of the underlying delivery system, much as different engines and tires can be placed on the same chassis. The programmable power of this type of modularity means the system has the potential to one day be used to treat a variety of diseases.

"We can finally integrate sensing and logical computing functions via complex, yet predictable, nanostructuressome of the first hybrids of structural DNA, antibodies, aptamers and metal atomic clustersaimed at useful, very specific targeting of human cancers and T-cells," said George Church, Ph.D., a Wyss core faculty member and Professor of Genetics at Harvard Medical School, who is Principal Investigator on the project.

Because DNA is a natural biocompatible and biodegradable material, DNA nanotechnology is widely recognized for its potential as a delivery mechanism for drugs and molecular signals. But there have been significant challenges to its implementation, such as what type of structure to create; how to open, close, and reopen that structure to insert, transport, and deliver a payload; and how to program this type of nanoscale robot.

By combining several novel elements for the first time, the new system represents a significant advance in overcoming these implementation obstacles. For instance, because the barrel-shaped structure has no top or bottom lids, the payloads can be loaded from the side in a single stepwithout having to open the structure first and then reclose it. Also, while other systems use release mechanisms that respond to DNA or RNA, the
'/>"/>

Contact: Mary Tolikas
mary.tolikas@wyss.harvard.edu
Wyss Institute for Biologically Inspired Engineering at Harvard
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. Lupus Research Institute Awards $3.6 Million for Novel Studies Driving Wide-Ranging New Science in Lupus
2. Van Andel Research Institute Study Provides New Details of Fundamental Cellular Process
3. Niels Bohr Institute gets top researcher from Harvard
4. DFH Pharma to Collaborate With National Cancer Institute to Develop Second-Generation HIV Maturation Inhibitor Drugs
5. QIAGEN and Max Planck Institute for Infection Biology Collaborate to Develop Assay for Active TB Risk in Individuals With Latent Infection
6. HealthCare Institute of New Jersey Releases 2011 Biopharmaceutical and Medical Technology Economic Impact Data
7. Michael A. Marletta Takes Office as New President of Scripps Research Institute
8. The Pharmabiotic Research Institute (PRI) is Preparing to Publish its First Works on the Therapeutic and Medicinal Potential of Probiotics
9. Van Andel Institute Partners with UNCF to Recruit Students to Biomedical Research Careers
10. Masaryk Memorial Cancer Institute Reduces Losses and Administrative Overhead With Ekahau RTLS
11. New England Research Institutes (NERI) Announces Additional $45M NIH Grant to Support the Pediatric Heart Network
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... 17, 2014 Based on the ... surgical imaging market is dominated by four major ... imaging market. These players include GE Healthcare (U.K.), ... (Germany). , Full Report Copy at ... Healthcare can be attributed to its strong product ...
(Date:12/17/2014)... TX (PRWEB) December 17, 2014 Achim ... and administration for Stoller Group. In this position, Noack ... Group, on administrative matters, develop marketing strategy and supervise ... services. , “Achim has tremendous knowledge and experience ... of Stoller Group. “His experience and innovative thinking will ...
(Date:12/17/2014)... 2014 Once more, EMAAR has ... packaged waste water treatment plant to phase one of ... (KAEC). Two years ago Bioshaft successfully supplied and operated ... two residential towers with an occupancy of 900 residences. ... million gallons per day and was signed on September ...
(Date:12/17/2014)... (PRWEB) December 17, 2014 Xeno ... Excellence following its most recent COLA inspection. Xeno ... COLA, a national healthcare accreditation organization. Accreditation is ... of quality in day-to-day operations, demonstrate continued accuracy ... a rigorous on-site laboratory survey. , ...
Breaking Biology Technology:Global Refurbished Surgical Imaging Market by Product & Application is Estimated to Reach $1.25 Billion by 2019 - New Research Report by MarketsandMarkets 2Global Refurbished Surgical Imaging Market by Product & Application is Estimated to Reach $1.25 Billion by 2019 - New Research Report by MarketsandMarkets 3Global Refurbished Surgical Imaging Market by Product & Application is Estimated to Reach $1.25 Billion by 2019 - New Research Report by MarketsandMarkets 4Achim Noack Joins Stoller Group as Global Vice President of Marketing and Administration 2Xeno Diagnostics Receives 3rd Award for Laboratory Excellence 2
... firm Bruker AXS announced on Tuesday it will ... materials research and analysis software. The deal is expected to ... transaction, which was finalized on Aug. 13 according to Bruker's ... Commission, states that Bruker will acquire all shares of SOCABIM's ...
... Wisconsin companies were among CIO Magazine's 2005 ... theme, the Bold 100, was awarded to companies the ... the company despite great risks. , ,Winners were selected ... detailing their practices in business and IT, review by ...
... the U.S. food supply from terrorism and natural disasters has ... its original November dates. , ,The Great Lakes Agro-Security ... Milwaukee, with as many as 1,000 people expected from the ... with the Wisconsin Procurement Institute, is helping to plan the ...
Cached Biology Technology:Bruker acquires French X-ray software company 2CUNA and Lands' End win IT applications award 2
(Date:11/21/2014)... Nov. 20, 2014 Strict laws against distracted ... piloting the North American and European automotive sector towards ... gesture recognition systems that are intuitive and able to ... the industry. New analysis from Frost ... Market in Europe and ...
(Date:11/21/2014)...   Atmel® Corporation (NASDAQ: ATML ... technology solutions, today launched the industry,s first family of ... V cc range from 1.7V to 5.5V. The ... 2 C bus communication speeds, and are available with ... ideal for consumer, industrial, computer, and medical applications. ...
(Date:11/18/2014)... , Nov. 17, 2014   ... EMC collaborate to develop The Partners Data Lake, ... The Partners Data Lake will allow researcher and ... diagnostics, treatment and the lives of patients ... and clinical activities across the Partners system, breaking ...
Breaking Biology News(10 mins):Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 2Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 4Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 2Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 3Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 2Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 3Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 5
... STATION N.J., PRINCETON, N.J. and JAMAICA PLAIN, Mass., ... (through an affiliate), Medarex, Inc. (NASDAQ: MEDX) and ... Massachusetts Medical School (UMMS) today announced that they ... CDA-1 and CDB-1 (also known as MDX-066/MDX-1388 and ...
... Cambridge, UK Wolf-Hirschhorn Syndrome (WHS) is a human ... with WHS have a characteristic set of facial features, ... forehead, and highly arched eyebrows. Other symptoms associated ... and skeletal abnormalities, and the severity of these symptoms ...
... AWRE ) today announced that it has amended and ... of comments and a request from the Securities and Exchange ... range of the tender offer to between $2.20 and $2.60 ... share. Aware has also extended the expiration date for the ...
Cached Biology News:Mass Biologic Labs/UMass Med School and Medarex license C. difficile monoclonal antibody to Merck 2Mass Biologic Labs/UMass Med School and Medarex license C. difficile monoclonal antibody to Merck 3Mouse model provides a new tool for investigators of human developmental disorder 2Aware, Inc. Amends and Extends Dutch Auction Tender Offer 2Aware, Inc. Amends and Extends Dutch Auction Tender Offer 3Aware, Inc. Amends and Extends Dutch Auction Tender Offer 4
Request Info...
...
...
... purified Formulation: 50mM Tris-HCl, pH ... 0.2mM PMSF, 1mM benzamidine, 0.1% ... PP2A1 (Protein Phosphatase 2A1) partially ... sulfate precipitation, QSepharose,amino-hexyl agarose, Superdex ...
Biology Products: