Navigation Links
Harvard Wyss Institute's Lung-on-a-Chip wins prize for potentially reducing need for animal testing

BOSTON, MA, February 26, 2013 In a London ceremony today, Wyss Founding Director Don Ingber, M.D., Ph.D., received the NC3Rs 3Rs Prize from the UK's National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) for his innovative Lung-on-a-Chip -- a microdevice lined by human cells that recapitulates complex functions of the living lung.

"We believe that our human breathing Lung-on-a-Chip, and other organ chips we have in development, represent a first wave of exciting new alternative approaches to animal testing that hopefully will change how drug development is carried out in the future," Ingber said. "This award helps to validate this radical new approach on the global stage, and to strengthen our resolve to work with government agencies and pharmaceutical companies that have been supporting our work to pursue this alternative approach to animal testing."

The lung-on-a-chip offers a new in vitro approach to drug screening by mimicking the complicated mechanical and biochemical behaviors of a human lung. It is a small device the size of a memory stick composed of a clear, flexible polymer that contains hollow channels fabricated using computer microchip manufacturing techniques.

Two of the channels are separated by a thin, flexible, porous membrane that is lined on one side with human lung cells from the air sac, and exposed to air; human capillary blood cells from the lung are placed on the other side with medium flowing over their surface to mimic blood flow. A vacuum applied to side channels deforms this tissue-tissue interface to re-create the way human lung tissues physically expand and retract when breathing.

In their latest publication in Science Translational Medicine being honored by this award, Ingber's team used the lung-on-a-chip to mimic a complex human disease: pulmonary edema, or "fluid on the lungs." They closely mimicked a drug toxicity that produces pulmonary edema in humans, identified potential new therapies to prevent this life-threatening condition, and revealed new insights about the disease -- specifically demonstrating on the chip that the physiological breathing motion of the lungs exacerbates drug toxicity-induced edema. They also studied the disease process in real time, precisely tracking fluid flow and clot formation, which cannot easily be done using an animal model.

"The NC3Rs annual 3Rs Prize champions the 3Rs globally [replacement, refinement, and reduction of animals used in research], rewarding real scientific and technological advances," said NC3Rs Chief Executive Vicky Robinson, Ph.D. Ingber and his team received a monetary award equivalent to about $30,000, which will be used to support continued research and collaboration around the on-chip technology.

"This disruptive technology may be the beginning of a revolution of the systems we use to model human disease and test drugs in the future, with great potential to reduce the need for animals," said Robinson.


Contact: Kristen Kusek
Wyss Institute for Biologically Inspired Engineering at Harvard

Related biology technology :

1. Harvards Wyss Institute team creates versatile 3d nanostructures using DNA bricks
2. Harvards Wyss Institute models a human disease in an organ-on-a-chip
3. UMass Amherst, Harvard experts say better systems needed for medical device cybersecurity
4. Harvards Wyss Institute creates living human gut-on-a-chip
5. Harvards Wyss Institute develops DNA nanorobot to trigger targeted therapeutic responses
6. Niels Bohr Institute gets top researcher from Harvard
7. Art Levinson, Sergey Brin and Anne Wojcicki, Mark Zuckerberg and Priscilla Chan, and Yuri Milner Announce the Breakthrough Prize in Life Sciences
8. Molecular Medicine Awards 1st Annual Ross Prize to NYU Researcher
9. Photonics21 Group Announces Prize for Photonics with Industrial Impact
10. Aspiring Photonics Entrepreneurs to Vie for Prizes, Connections in SPIE Startup Challenge
11. Win $1000 in prizes from the Christmas MEGA Sweepstakes from Sweepstakes Ninja
Post Your Comments:
Related Image:
Harvard Wyss Institute's Lung-on-a-Chip wins prize for potentially reducing need for animal testing
(Date:11/24/2015)... Switzerland (PRWEB) , ... November 24, 2015 , ... ... plant and the environment are paramount. Insertion points for in-line sensors can represent ... has developed the InTrac 781/784 series of retractable sensor housings , which ...
(Date:11/24/2015)... , Nov. 24, 2015 HemoShear ... on discovering drugs for metabolic disorders, announced today ... to its Board of Directors (BOD). Mr. Watkins ... of Human Genome Sciences (HGS), and also served ... Jim Powers , Chairman and CEO ...
(Date:11/23/2015)... , Nov. 24, 2015 Women with a ... CT exams face a higher risk of lung cancer than ... presented next week at the annual meeting of the Radiological ... --> --> Lung nodules ... classified as solid or subsolid based on their appearance on ...
(Date:11/23/2015)... The royalty-free a greement a llows ... 112 low- and m iddle-i ncome ... --> The Medicines Patent Pool (MPP) today announced its ... with Bristol-Myers Squibb for daclatasvir, a novel direct-acting antiviral that ... virus.  The royalty-free licence will enable generic manufacture of daclatasvir ...
Breaking Biology Technology:
(Date:11/12/2015)... Nov. 12, 2015  A golden retriever that stayed ... dystrophy (DMD) has provided a new lead for treating ... the Broad Institute of MIT and Harvard and the ... . Cell, pinpoints a protective ... the disease,s effects. The Boston Children,s lab of ...
(Date:11/10/2015)... , Nov. 10, 2015  In this ... the basis of product, type, application, disease ... in this report are consumables, services, software. ... are safety biomarkers, efficacy biomarkers, and validation ... report are diagnostics development, drug discovery and ...
(Date:11/4/2015)... York , November 4, 2015 ... a new market report published by Transparency Market Research "Home ... Growth, Trends and Forecast 2015 - 2022", the global home ... US$ 30.3 bn by 2022. The market is estimated ... forecast period from 2015 to 2022. Rising security needs ...
Breaking Biology News(10 mins):