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Halozyme's Ultrafast Insulin Generates Faster-In and Faster-Out Profile for Type 1 Diabetes Patients Using Insulin Pumps
Date:4/14/2011

SAN DIEGO, April 14, 2011 /PRNewswire/ -- Halozyme Therapeutics, Inc. (Nasdaq: HALO) today announced results from a study in type 1 diabetes patients who receive their insulin treatment with a pump demonstrating that Aspart-PH20, a formulation of Halozyme's rHuPH20 (recombinant human hyaluronidase) with the active ingredient in NovoLog®, accelerates insulin absorption and shortened its duration of action. These preliminary results represent the first reported experience in a clinical trial where patients received rHuPH20 enzyme combined with an insulin analog as a continuous subcutaneous insulin infusion (CSII) over 72 hours administered with an insulin pump. Halozyme presented these results today at the American Association of Clinical Endocrinologists (AACE) meeting in San Diego.  

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"The initial results from Halozyme's first pump study show that the faster pharmacokinetic and glucodynamic findings consistently demonstrated with mealtime subcutaneous insulin injections are also observed in the CSII setting," stated Doug Muchmore, M.D., vice president of endocrinology clinical development. "The ultrafast profile of analog insulin with rHuPH20 is well suited for use with insulin pumps."

Key Findings from Today's Oral Presentation  

The first stage of this double blind crossover design Phase 1 clinical trial compared Aspart-PH20 to aspart alone in type 1 diabetes patients who administered their insulin over 72 hours with an insulin pump. The cumulative insulin exposure during the first 60 mi
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SOURCE Halozyme Therapeutics, Inc.
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