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Halozyme Therapeutics Reports 2008 First Quarter Financial Results
Date:5/8/2008

in combination with PH20.

-- New safety and pharmacokinetic data from a second generation

manufacturing process for recombinant human PH20 enzyme. The data from

three studies were presented at the European Federation for

Pharmaceutical Sciences meeting for Development of Safe Protein

Therapeutics: Preclinical, Clinical and Regulatory Issues. The

presented studies investigated the IV and subcutaneous (SC) safety

assessment of PH20 administered to non-human primates at significantly

higher doses than previously examined. PH20 from a first generation

manufacturing process has been studied in a different formulation with

lower concentrations for SC injection as an adjuvant to increase

absorption and dispersion of other injected drugs and for SC fluid

administration. In a pharmacokinetic (PK) dose-range finding study,

doses up to 3,600,000 U/kg (30mg/kg) of the second generation enzyme

were well-tolerated following either IV or SC dosing.

-- Publication of the INFUSE-LR clinical trial results in the Journal of

Palliative Medicine, the official journal of the American Academy of

Palliative Medicine (Thomas JR et al. J Pall Med. December 2007;

19(6):1312-1320). The authors of this publication concluded from this

volunteer subject study that clinically relevant fluid volumes can be

rapidly delivered subcutaneously with HYLENEX in a well-tolerated

manner without the need for an infusion pump. The findings suggest

that this method of hydration could potentially replace intravenous

infusions in many clinical settings and that further studies with

HYLENEX, in patients, are warranted.

Upcoming Scientific Data Presentations

-- International Investigative Dermatology - May 14-17th - presentation

of "Temporal-Spatial Con
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SOURCE Halozyme Therapeutics, Inc.
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