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Halozyme Therapeutics Reports 2008 First Quarter Financial Results

ults at the annual meeting of the

American Academy of Allergy, Asthma & Immunology (AAAAI) in

Philadelphia, PA.

-- New pre-clinical findings on the treatment of prostate cancer models

at the American Association for Cancer Research conference. The

studies explored the physiologic responses to enzymatic removal of

hyaluronic acid (HA)-based matrices surrounding tumor cells in the

tumor microenvironment of prostate tumors following systemic

administration of its pegylated rHuPH20 (PEG PH20) pre-clinical

candidate. The objectives of these studies were to determine whether

HA-dependent pericellular matrices produced in vitro and in vivo by a

hormone refractory prostate cancer cell line could be enzymatically

depleted in prostate carcinoma xenografts following intravenous (IV)

administration of the PEG PH20 enzyme. In mice, IV PEG PH20 collapsed

the protective HA-based pericellular matrices of prostate cancer cells

and selectively increased tumor vascular volume 3.5-fold.

-- Findings on the local tolerability and pharmacokinetics of

bisphosphonates combined with PH20 at the American Association for

Cancer Research conference. The objectives of the presented studies

were to investigate in animal models whether increasing the dispersion

and absorption of bisphosphonates in the skin and subcutaneous tissues

with PH20 could modify injection site reaction profiles from two

intravenous bisphosphonate formulations, zoledronic acid and

ibandronate. The pharmacokinetics of bisphosphonates in blood were

also examined and compared to intravenous infusion. The maximal

concentration of bisphosphonates that could be administered without

producing injection site reactions was increased 3-to-5 fold when


SOURCE Halozyme Therapeutics, Inc.
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