Navigation Links
HIV prevention science scores a victory -- the gel works!
Date:7/19/2010

Vienna, Austria July 20, 2010 Today at the XVIII International AIDS Conference in Vienna, Austria, members of the International Rectal Microbicide Advocates (IRMA) and thousands of other HIV advocates and scientists cheered a long-awaited, much anticipated success in the quest for new HIV prevention technologies. Researchers announced that a vaginal gel has been shown to significantly reduce a woman's risk of being infected with HIV and genital herpes.

These game-changing results of the safety and effectiveness study of an antiretroviral microbicide gel were reported by the Centre for the AIDS Programme of Research in South Africa (CAPRISA).

The microbicide gel that CAPRISA studied contained 1% tenofoviran antiretroviral drug commonly used to treat people living with HIVand was found to be 39% effective in reducing a woman's risk of becoming infected with HIV during vaginal intercourse and 51% effective in preventing genital herpes infections among the women in the trial. These protective effects increased as the use of tenofovir increased, so that women who used the gel in more than 80% of their sex acts during the trial had a 54% reduction in HIV infections. If and when other studies of tenofovir gel confirm these results, widespread use of the gel, at this level of protection, could prevent millions of new HIV infections over the next two decades. Tenofovir is also being studied as a form of oral pre-exposure prophylaxis.

"The positive results from the CAPRISA 004 study represent a very significant milestone in HIV prevention research and they increase optimism that we can develop safe and effective antiretroviral rectal microbicides," said University of Pittsburgh's Dr. Ian McGowan, IRMA Scientific Vice-Chair and co-principal investigator of the Microbicide Trials Network. "Phase I rectal safety studies with tenofovir are ongoing and these efforts need to be intensified to help us move forward to rectal microbicide effectiveness studies as quickly as possible," he said.

As with vaginal microbicides, safe and effective rectal microbicides are urgently needed by millions of people. Anal intercourse is a common human sexual behavior, practiced by approximately 5 10% of the world's general population, including heterosexual women and men, gay men, and other men who have sex with men (MSM). Because an act of unprotected anal intercourse is 10 to 20 times more likely to result in HIV transmission compared to unprotected vaginal intercourse, it is likely that unprotected anal intercourse is a significant driver in the global HIV epidemic.

"Certainly, for gay men and other MSM across the world, unprotected anal intercourse is the chief cause of HIV infection," said IRMA Chair Jim Pickett. "But the world has largely ignored gay men, and anal intercourse. Gay men and other MSM are under-represented in most national AIDS strategies, in epidemiology, surveillance, and in research, if they show up at all. They have been woefully underserved by prevention, care, treatment and support services. "Similarly," he continued, "there is a paucity of data regarding anal intercourse homosexual and heterosexual due to politics, stigma, criminalization, and outright denial."

Globally, gay men and other MSM are 19 times more likely to be HIV infected compared to the general population. These disproportionate rates extend to Africa, where the epidemic is often characterized as "heterosexual." In Uganda for instance, HIV rates among gay men and other MSM are just above 40% compared to 5% for men of reproductive age. In South Africa, where the global AIDS pandemic is most severe, the HIV rates between gay men/MSM and men of reproductive age are almost the same both hovering around 15%.

Comparing gay men and other MSM to both males and females of reproductive age, gay men and MSM are 1.3 times more likely to be HIV-infected in Eastern Europe, 3.8 times more likely in Africa, 18.7 times more likely in Asia, and 33.3 times more likely in the Americas. Data released by the U.S. Centers for Disease Control and Prevention in early 2010 revealed that gay men/MSM in the United States are 44 times more likely to be HIV-positive than other men, and 40 times more likely to be HIV-positive than women.

"The bottom line is, for the men and women who engage in anal intercourse, condoms work quite well to prevent HIV," said Pickett, "but many people do not use them, or are simply unable to use them due to a number of issues including power dynamics in sexual relationships, stigma, and a serious lack of availability. According to the Global HIV Prevention Working Group, only 9% of individuals at risk for HIV infection had access to condoms in 2008. Condom-compatible lubricants are also in dangerously short supply."

While the rectal microbicide field has gained significant momentum, more focus and resources are needed. In 2010, U.S. $7.2 million is being spent globally on rectal microbicide research. IRMA has calculated that annual investments must increase by 40% from 2011 2014, to U.S. $10 million/year and must increase further to U.S. $44 million (a six-fold increase) in the years 2015 2020 to ensure a minimum of candidate products are moving through the research pipeline into late stage testing for effectiveness.

"We are optimistic that the CAPRISA results will not only accelerate the development of safe and effective vaginal microbicides, but that this proof of concept will also be translated into more financial and creative energy into rectal microbicide development," said Pickett. "With five new infections for every two individuals beginning treatment, it's absolutely imperative we find new ways to prevent HIV for individuals at risk, gay and straight, women and men."


'/>"/>

Contact: Jim Pickett
jpickett@aidschicago.org
773-600-6407
International Rectal Microbicide Advocates
Source:Eurekalert

Related biology technology :

1. FDA Approves ALOXI(R) (Palonosetron HCl) Capsules for Prevention of Acute Chemotherapy-induced Nausea and Vomiting
2. Society of Gynecologic Oncologists to Host Cervical Cancer Prevention Forum
3. Integrated Prevention Demonstration Campaign Launched in Western Kenya to Fight HIV, Malaria and Diarrhoeal Disease
4. Major Adult Vaccine Clinical Trial for Pneumonia Prevention Begins
5. Asenapine Meets Primary Endpoint in Long-Term Schizophrenia Relapse Prevention Trial
6. Portola Pharmaceuticals Initiates Phase II Trial of Betrixaban, its Novel Oral Factor Xa Inhibitor for Stroke Prevention in Atrial Fibrillation
7. Gene Signal Enters Phase III Clinical Tests for the Prevention of Corneal Graft Rejection
8. New Health Retreat Gives a Fresh Attitude Towards Disease Prevention
9. PharmAthene Presents Data for SparVax(TM) and Valortim(R), a Novel Vaccine and Anti-Toxin for the Prevention and Treatment of Anthrax Infection at the 7th Annual ASM Biodefense Meeting
10. EyeScience Launches Comprehensive Online Resource Devoted to Age-Related Macular Degeneration Education and Prevention
11. AMPAC Fine Chemicals Receives the California Pollution Prevention Challenge Award Two Consecutive Years
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/8/2016)... ... December 08, 2016 , ... ... for their exceptionally efficient human mesenchymal stem/stromal cell (hMSC) expansion medium. ... media products engineered to radically streamline culture processes, minimize processing time, significantly ...
(Date:12/8/2016)... , Dec. 8, 2016  Soligenix, Inc. (OTCQB: ... company focused on developing and commercializing products to ... medical need, announced today the long-term follow-up data ... (dusquetide), a first-in-class Innate Defense Regulator (IDR), in ... and neck cancer patients undergoing chemoradiation therapy (CRT).  ...
(Date:12/8/2016)... N.J. , Dec. 8, 2016 ... augmentation remediation technologies and selected NewTechBio,s NT-MAX ... a microbial based beneficial bacteria, in conjunction with ... to correct deficiencies with National Pollutant Discharge Elimination ... 281-8H has experienced a steady history of elevated ...
(Date:12/8/2016)... 8, 2016   Biocept, Inc . (NASDAQ: ... of clinically actionable liquid biopsy tests to improve ... data featuring its Target Selectorâ„¢ Circulating Tumor Cell ... the detection of actionable biomarkers in patients with ... by Sara Cannon Research Institute (SCRI), the research ...
Breaking Biology Technology:
(Date:11/28/2016)... "The biometric system market projected to ... system market is in the growth stage and is ... biometric system market is expected to be valued at ... 16.79% between 2016 and 2022. Government initiative in adoption ... rising use of biometric technology in financial institutes and ...
(Date:11/21/2016)... 21, 2016   Neurotechnology , a provider ... today announced that the MegaMatcher On Card fingerprint ... for the NIST Minutiae Interoperability Exchange (MINEX) ... mandatory steps of the evaluation protocol. ... test of fingerprint templates used to establish compliance ...
(Date:11/16/2016)... Calif. , Nov. 16, 2016 ... user experience and security for consumer electronics, and ... the financial and retail industry, today announced a ... and convenient way to authenticate users of mobile ... Sensory,s TrulySecureâ„¢ software which requires no ...
Breaking Biology News(10 mins):