Navigation Links
HIV-1 vaccine development: Pinning down a moving target
Date:11/12/2012

HIV-1 is a genetically diverse collection of viruses, making it a moving target in vaccine development. In a study published in the Journal of Clinical Investigation, researchers led by Brad Jones at the University of Toronto in investigated the feasibility of eliminating HIV-infected cells by targeting cellular immune responses against a human endogenous retrovirus (HERV). HERVs are the DNA remnants of ancient infectious retroviruses that became part of the germ line cells of our ancestors. Jones and colleagues found that HIV infection stimulated the expression of HERV proteins, effectively tagging HIV-infected cells. Immune cells targeted to these proteins specifically eliminated cells infected with several different strains of HIV in vitro. This study suggests that HERV-targeted immune responses should be considered in the development of HIV vaccines.

TITLE:
HERV-K-targeted T-cells eliminate diverse HIV-1/2 and SIV primary isolates

AUTHOR CONTACT:
Brad Jones
University of Toronto, Toronto, ON, CAN
Phone: 617-777-9151; E-mail: bjones.ut@gmail.com

View this article at: http://www.jci.org/articles/view/64560?key=6bb3867c449f3c243fb1


'/>"/>

Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

Page: 1

Related biology technology :

1. "Sitting Ducks" No Longer: Advance Flu Warning Permits Creation of Replikins Custom Synthetic Flu Vaccine in Animals
2. A New Type of Dendritic Cell-Based Cancer Vaccine has Received Approval for Clinical Tests and at the Same Time Secures Substantial Financing
3. Breast Cancer Vaccine Being Developed by Generex Subsidiary Antigen Express to be Featured on Bloomberg Television Today
4. Generex Subsidiary Antigen Express Provides Update on AE37 Cancer Vaccines Clinical & Regulatory Strategy
5. Aeras and CNBG Sign Agreement on Tuberculosis Vaccine R&D
6. Generex Announces Patent Award for its Core Vaccine Technologies in Japan
7. ResearchMoz: Vaccine Production Market (Trends, Techniques, Key Players, Spending Estimates and Forecasts)
8. Discovery in Nature elucidates immune cells in skin and supports novel vaccine approach
9. GeoVax Labs Presents New Findings on Potential HIV Vaccine at 2012 Conference on Retroviruses and Opportunistic Infections (CROI)
10. AlphaVax Announces Nomination for 2012 Vaccine Industry Excellence Award
11. Generex Subsidiary Antigen Express Announces Press Conference at American Association for Cancer Research Related to the Immunological Response of its AE37 Vaccine to Prevent Recurrence of Breast Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/4/2015)... , May 4, 2015   St. ... a significantly better computer tool for finding genetic ... cancers but were difficult to identify with whole-genome ... journal Nature Methods . The ... Copy Number Segmentation by Regression Tree in Next ...
(Date:5/4/2015)... , May 4, 2015 GliaCure, a ... novel therapies for neurological and neuropsychiatric disorders based ... dosing of Alzheimer,s patients in a Phase 1b ... a compound developed as a potential disease-modifying treatment. ... innovative in that it both promotes the clearance ...
(Date:5/4/2015)... TEL AVIV, Israel , May 4, 2015 /PRNewswire/ ... has filed its annual report on Form 20-F for ... U.S. Securities and Exchange Commission ("SEC"). The annual report ... for the development of antibodies in the area of ... antibodies with superior qualities of high specificity and binding ...
(Date:5/4/2015)... , May 4, 2015  Traverse Biosciences ... cooperative research and development agreement (CRADA) with Aratana ... the development of TRB-N0224 for the treatment and ... dogs and cats.  Traverse Biosciences has also granted ... the treatment and control of periodontal disease in ...
Breaking Biology Technology:Scientists dramatically improve method for finding common genetic alterations in tumors 2Scientists dramatically improve method for finding common genetic alterations in tumors 3Scientists dramatically improve method for finding common genetic alterations in tumors 4GliaCure Initiates Phase 1b Dosing in Alzheimer's Patients 2Tikcro Technologies Files Annual Report on Form 20-F for the Year Ended December 31, 2014 2Traverse Biosciences Executes Agreement with Aratana Therapeutics to Advance Development of TRB-N0224 for the Treatment and Control of Periodontal Disease in Pets 2Traverse Biosciences Executes Agreement with Aratana Therapeutics to Advance Development of TRB-N0224 for the Treatment and Control of Periodontal Disease in Pets 3Traverse Biosciences Executes Agreement with Aratana Therapeutics to Advance Development of TRB-N0224 for the Treatment and Control of Periodontal Disease in Pets 4
... Rising star Divine Skin Inc. (DSKX), which has been expanding ... long-time leader in the cosmetics industry, to become its president. ... Divine Skin because I believe their innovative products are unmatched ... with a ,wow, factor." A dozen Divine ...
... 25, 2011 For the first time, Eli Lilly and ... to more than 800 grassroots projects across the globe and ... Foundation—doubling the value and impact of each employee,s charitable contribution. ... to offer its employees across the world a customized Lilly ...
... Sciences International, Inc. (Nasdaq: BDSI ) announced ... portion of its Phase 3 clinical trial assessing the ... of moderate to severe chronic pain, signifying completion of ... are very pleased to have brought to completion our ...
Cached Biology Technology:Robin Powell Becomes President at Biotech Leader Divine Skin (DSKX) 2Lilly Global Giving Puts Power of Philanthropy in Employees' Hands 2Lilly Global Giving Puts Power of Philanthropy in Employees' Hands 3Lilly Global Giving Puts Power of Philanthropy in Employees' Hands 4BioDelivery Sciences Announces Completion of BEMA Buprenorphine Phase 3 Chronic Pain Study 2BioDelivery Sciences Announces Completion of BEMA Buprenorphine Phase 3 Chronic Pain Study 3
(Date:4/27/2015)... 2015  For more than four decades, AUVSI,s ... the premier worldwide event for the unmanned land, sea, ... event for any local, national, or trade news organization ... markets and current applications of unmanned technologies. The conference ... $48 billion industry, and how it will soon impact ...
(Date:4/27/2015)... Conn. , Apr. 27, 2015 NXT-ID, ... a biometric authentication company focused on the growing mobile ... commence shipping to pre-order customers the first week of ... through the month of May. ... a significant milestone for the company as Wocket® enters ...
(Date:4/27/2015)... 2015 Profile Solutions, Inc. (OTC: PSIQ), a ... is pleased to announce that Dr Gerry Bedore ... member of its scientific advisory board. ... thought leader in technology-enhanced learning models. He was a ... published studies and books focused on online student success ...
Breaking Biology News(10 mins):UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 2UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 3UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 4UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 5Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 2Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 3Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 2Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 3Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 4
... immune system,s healthy scavenger cells, play a key role in ... of the body, according to research to be presented Sunday, ... meeting in New Orleans. The researchers, Alain Silk, ... Science University (OHSU) in Portland followed the work of German ...
... fundamental question in cell biology and showing off the ... discovered where the Golgi apparatus, which sorts newly synthesized ... when it disassembles during cell division, according to research ... American Association for Cell Biology (ASCB) annual meeting in ...
... glucose metabolism dials down influenza viral infection in laboratory cell ... according to research that will be presented on Sunday, Dec. ... meeting in New Orleans. While annual flu shots ... (CDC),s predictions of the viruses that will be in ...
Cached Biology News:Spontaneous fusion with macrophages empowers cancer cells to spread 2High-resolution 3-D imaging draws new picture of Golgi's whereabouts during cell division 2Glucose: Potential new target for combating annual seasonal influenza 2Glucose: Potential new target for combating annual seasonal influenza 3
... custom siRNA service provides the premium quality ... research. Custom siRNAs can be readily ordered ... target sequence, or by providing the sense ... Ambion's Silencer Validated and ...
... the premium quality siRNAs you need for ... be readily ordered online by providing either ... providing the sense and antisense siRNA sequences. ... Validated and Silencer Pre-designed siRNAs, ...
dithiothreitol, sulfhydryl reducing agent, C4H10O2S2; MW: 154.24, 97% pure (minimum), CAS No: 27565-41-9, store at -20 C ...
... NAP-10 Columns, 50. For rapid and ... 10-mers) in less than 15 minutes by ... in distilled water containing 0.15% Kathon CG/ICP ... volume: 0.5 ml (NAP-5), 1 ml ...
Biology Products: