Navigation Links
HIV-1 vaccine development: Pinning down a moving target
Date:11/12/2012

HIV-1 is a genetically diverse collection of viruses, making it a moving target in vaccine development. In a study published in the Journal of Clinical Investigation, researchers led by Brad Jones at the University of Toronto in investigated the feasibility of eliminating HIV-infected cells by targeting cellular immune responses against a human endogenous retrovirus (HERV). HERVs are the DNA remnants of ancient infectious retroviruses that became part of the germ line cells of our ancestors. Jones and colleagues found that HIV infection stimulated the expression of HERV proteins, effectively tagging HIV-infected cells. Immune cells targeted to these proteins specifically eliminated cells infected with several different strains of HIV in vitro. This study suggests that HERV-targeted immune responses should be considered in the development of HIV vaccines.

TITLE:
HERV-K-targeted T-cells eliminate diverse HIV-1/2 and SIV primary isolates

AUTHOR CONTACT:
Brad Jones
University of Toronto, Toronto, ON, CAN
Phone: 617-777-9151; E-mail: bjones.ut@gmail.com

View this article at: http://www.jci.org/articles/view/64560?key=6bb3867c449f3c243fb1


'/>"/>

Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

Page: 1

Related biology technology :

1. "Sitting Ducks" No Longer: Advance Flu Warning Permits Creation of Replikins Custom Synthetic Flu Vaccine in Animals
2. A New Type of Dendritic Cell-Based Cancer Vaccine has Received Approval for Clinical Tests and at the Same Time Secures Substantial Financing
3. Breast Cancer Vaccine Being Developed by Generex Subsidiary Antigen Express to be Featured on Bloomberg Television Today
4. Generex Subsidiary Antigen Express Provides Update on AE37 Cancer Vaccines Clinical & Regulatory Strategy
5. Aeras and CNBG Sign Agreement on Tuberculosis Vaccine R&D
6. Generex Announces Patent Award for its Core Vaccine Technologies in Japan
7. ResearchMoz: Vaccine Production Market (Trends, Techniques, Key Players, Spending Estimates and Forecasts)
8. Discovery in Nature elucidates immune cells in skin and supports novel vaccine approach
9. GeoVax Labs Presents New Findings on Potential HIV Vaccine at 2012 Conference on Retroviruses and Opportunistic Infections (CROI)
10. AlphaVax Announces Nomination for 2012 Vaccine Industry Excellence Award
11. Generex Subsidiary Antigen Express Announces Press Conference at American Association for Cancer Research Related to the Immunological Response of its AE37 Vaccine to Prevent Recurrence of Breast Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/19/2017)... ... 18, 2017 , ... A number of new instruments have recently emerged to ... the Protein and Cell Analysis Education Webinar Series , will focus on advances ... current and future applications. , Many flow cytometers have unique capabilities and the ...
(Date:4/19/2017)... ... April 18, 2017 , ... Optofluidics ... The move comes after the company changed focus to making analytical tools for ... and our new technology,” says CEO Robert Hart. Founders Bernardo Cordovez, Robert Hart ...
(Date:4/19/2017)... ... April 19, 2017 , ... ThermaGenix, the PCR Improvement ... adds to several other early achievements at ThermaGenix, including the business formation and ... , ThermaGenix will use proceeds from the Series A-1 round to:, ...
(Date:4/19/2017)... Linda, Ca (PRWEB) , ... April 19, 2017 ... ... University Virtual Event, which makes educational webinars accessible to novices as well ... impact of preanalytical variables of commonly performed coagulation screening tests. , Hemostasis ...
Breaking Biology Technology:
(Date:4/11/2017)... , April 11, 2017 Crossmatch®, ... secure authentication solutions, today announced that it has ... Advanced Research Projects Activity (IARPA) to develop next-generation ... program. "Innovation has been a driving ... Thor program will allow us to innovate and ...
(Date:4/6/2017)... 2017 Forecasts by Product Type ... by End-Use (Transportation & Logistics, Government & Public Sector, ... Fossil Generation Facility, Nuclear Power), Industrial, Retail, Business Organisation ... Are you looking for a definitive report on the ... ...
(Date:4/4/2017)... --  EyeLock LLC , a leader of iris-based identity ... and Trademark Office (USPTO) has issued U.S. Patent No. ... iris image with a face image acquired in sequence ... th issued patent. "The issuance ... multi-modal biometric capabilities that have recently come to market ...
Breaking Biology News(10 mins):