Navigation Links
Grant to explore better methods for delivering antidotes after chemical attacks
Date:9/20/2013

A new $4.47 million project at the University of North Carolina at Chapel Hill, funded by the Defense Threat Reduction Agency, will help lay the groundwork for developing potentially better ways to deliver antidotes against exposure to chemical weapons. The work could ultimately help both civilian and military populations through the design of precisely engineered particles and microneedle patches that are loaded with a nerve gas antidote that can be easily administered in the event of an attack.

Researchers at UNC will use the PRINT technology, also known as Particle Replication In Non-wetting Templates, to design and optimize the size, shape and composition of particles and microscopic needles that can carry life-saving antidotes to chemical nerve gas. If successful, the application of this technology could make it easier to deliver drugs faster to counteract severe reactions to chemical agents.

"Finding the fastest, most effortless method to administer antidotes during a nerve gas attack can be crucial for saving lives," said Joseph DeSimone, Chancellor's Eminent Professor of Chemistry at UNC and William R. Kenan Jr. Distinguished Professor of Chemical Engineering at N.C. State University and of Chemistry at UNC.

A central part of the five-year project will be to optimize the design attributes of precisely uniform arrays of microneedles, tiny structures that would be incorporated into a patch that can be applied directly to the skin where the microneedles dissolve for rapid absorption of the nerve gas antidote. Once the mode of delivery is optimized, the PRINT technology also allows for large-scale manufacturing of these microneedle patches and other possible antidote systems.

"Every second matters when someone is exposed to a chemical agent, so identifying a way to simply slap a patch onto someone's arm, in an instant, could have a life-saving impact," said DeSimone. "We are trying to find the best way to make the delivery of an antidote easy, effective and widely accessible."

DeSimone, who will lead the project, invented the PRINT technology with his students in 2004. The PRINT technology is licensed to Liquidia Technologies (Research Triangle Park, NC) for the development of a wide range of vaccines and therapeutics. Liquidia was co-founded by DeSimone, also in 2004.


'/>"/>

Contact: Thania Benios
thania_benios@unc.edu
919-962-8596
University of North Carolina at Chapel Hill
Source:Eurekalert

Related biology technology :

1. FDA Grants Soligenix Orphan Drug Designation for SGX94 for Treatment of Acute Radiation Syndrome
2. Crowdfunding Expert Kendall Almerico Discusses Scientists Using Crowdfunding to Replace Research Grants
3. Star Scientific Announces Patent Claims to Anatabine Citrate to be Granted by PTO
4. Genia Technologies, Columbia University, and Harvard University Awarded $5.25 Million Grant from NIH to Accelerate the Development of NanoTag DNA Sequencing Technology
5. Hovione: EPO Grants a New Inhaler Patent
6. 5 Washington organizations make joint grant
7. Women in Science Grant Challenges Status Quo Animal Research
8. VolitionRx-led Consortium Awarded euro 780 000 ($1M approx.) Eurostars Grant
9. Wayne State receives National Science Foundation grant for training future nanoengineers
10. UMass Boston Receives $1 Million Grant to Recruit Urban Nurse Leaders
11. VG Energy Chief Scientist Awarded $200,000 AgriLife Grant to Study Lipid Secretion
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/6/2016)... ... February 06, 2016 , ... Contact:, Abby ... for Excellence in Education Sponsors Teacher Training Program , Bite of Science Dinner ... The Center for Excellence in Education (CEE) will sponsor a Bite of Science ...
(Date:2/5/2016)... On Thursday, February 11, 2-1-1 San ... health and disaster services, and the Community Information ... care coordination and service delivery for the community to ... to better connect service providers to the information they ... Diego has handled more than 2.5 million ...
(Date:2/4/2016)... ... February 04, 2016 , ... Morf Media ... announced an interactive FDA compliance training course, Writing Effective SOPs ... Society) accredited interactive course on Morf Playbook—now conveniently available on smartphones and PCs--provides ...
(Date:2/4/2016)... ... 04, 2016 , ... Shimadzu Scientific Instruments will showcase several ... and poster sessions, and present on the analysis of mycotoxins and medical cannabis ... to 10 at the Georgia World Congress Center in Atlanta, Georgia. , ...
Breaking Biology Technology:
(Date:2/3/2016)... , February 4, 2016 --> ... to SEK 1,351.5 M (105.0), up 1,187% compared with fourth quarter of ... amounted to SEK 517.6 M (loss: 30.0). Earnings per share ... activities was SEK 537.4 M (neg: 74.7). , ... , Revenues amounted to SEK 2,900.5 M (233.6), up 1,142% compared with ...
(Date:2/3/2016)... , Feb. 3, 2016 Vigilant Solutions announces ... Department in Missouri solved two ... reader (LPR) data from Vigilant Solutions. Brian ... in which the victim was walking out of a convenience store and witnessed ... next to his vehicle, striking his vehicle and leaving ...
(Date:2/2/2016)... 2016  BioMEMS devices deployed in hospitals ... medical screening and diagnostic applications, such as ... that facilitate and assure continuous monitoring without ... being bolstered through new opportunities offered by ... coupled with wireless connectivity and low power ...
Breaking Biology News(10 mins):