Navigation Links
Grant to explore better methods for delivering antidotes after chemical attacks

A new $4.47 million project at the University of North Carolina at Chapel Hill, funded by the Defense Threat Reduction Agency, will help lay the groundwork for developing potentially better ways to deliver antidotes against exposure to chemical weapons. The work could ultimately help both civilian and military populations through the design of precisely engineered particles and microneedle patches that are loaded with a nerve gas antidote that can be easily administered in the event of an attack.

Researchers at UNC will use the PRINT technology, also known as Particle Replication In Non-wetting Templates, to design and optimize the size, shape and composition of particles and microscopic needles that can carry life-saving antidotes to chemical nerve gas. If successful, the application of this technology could make it easier to deliver drugs faster to counteract severe reactions to chemical agents.

"Finding the fastest, most effortless method to administer antidotes during a nerve gas attack can be crucial for saving lives," said Joseph DeSimone, Chancellor's Eminent Professor of Chemistry at UNC and William R. Kenan Jr. Distinguished Professor of Chemical Engineering at N.C. State University and of Chemistry at UNC.

A central part of the five-year project will be to optimize the design attributes of precisely uniform arrays of microneedles, tiny structures that would be incorporated into a patch that can be applied directly to the skin where the microneedles dissolve for rapid absorption of the nerve gas antidote. Once the mode of delivery is optimized, the PRINT technology also allows for large-scale manufacturing of these microneedle patches and other possible antidote systems.

"Every second matters when someone is exposed to a chemical agent, so identifying a way to simply slap a patch onto someone's arm, in an instant, could have a life-saving impact," said DeSimone. "We are trying to find the best way to make the delivery of an antidote easy, effective and widely accessible."

DeSimone, who will lead the project, invented the PRINT technology with his students in 2004. The PRINT technology is licensed to Liquidia Technologies (Research Triangle Park, NC) for the development of a wide range of vaccines and therapeutics. Liquidia was co-founded by DeSimone, also in 2004.


Contact: Thania Benios
University of North Carolina at Chapel Hill

Related biology technology :

1. FDA Grants Soligenix Orphan Drug Designation for SGX94 for Treatment of Acute Radiation Syndrome
2. Crowdfunding Expert Kendall Almerico Discusses Scientists Using Crowdfunding to Replace Research Grants
3. Star Scientific Announces Patent Claims to Anatabine Citrate to be Granted by PTO
4. Genia Technologies, Columbia University, and Harvard University Awarded $5.25 Million Grant from NIH to Accelerate the Development of NanoTag DNA Sequencing Technology
5. Hovione: EPO Grants a New Inhaler Patent
6. 5 Washington organizations make joint grant
7. Women in Science Grant Challenges Status Quo Animal Research
8. VolitionRx-led Consortium Awarded euro 780 000 ($1M approx.) Eurostars Grant
9. Wayne State receives National Science Foundation grant for training future nanoengineers
10. UMass Boston Receives $1 Million Grant to Recruit Urban Nurse Leaders
11. VG Energy Chief Scientist Awarded $200,000 AgriLife Grant to Study Lipid Secretion
Post Your Comments:
(Date:10/10/2017)... ... October 10, 2017 , ... ... program has won a US2020 STEM Mentoring Award. Representatives of the FirstHand program ... in Volunteer Experience from US2020. , US2020’s mission is to change the trajectory ...
(Date:10/10/2017)... , Oct. 10, 2017 International research firm Parks ... Strategy, will speak at the TMA 2017 Annual Meeting , October ... trends in the residential home security market and how smart safety and ... Parks ... "The residential ...
(Date:10/10/2017)... ... 10, 2017 , ... USDM Life Sciences , the ... sciences and healthcare industries, announces a presentation by Subbu Viswanathan and Jennifer Jaye ... GxP Validation for Agile Cloud Platforms,” will present a revolutionary approach to achieving ...
(Date:10/9/2017)... DIEGO , Oct. 9, 2017  BioTech ... biological mechanism by which its ProCell stem cell ... critical limb ischemia.  The Company, demonstrated that treatment ... amount of limbs saved as compared to standard ... the molecule HGF resulted in reduction of therapeutic ...
Breaking Biology Technology:
(Date:4/6/2017)... Forecasts by Product Type (EAC), Biometrics, Card-Based ... & Logistics, Government & Public Sector, Utilities / Energy ... Nuclear Power), Industrial, Retail, Business Organisation (BFSI), Hospitality & ... for a definitive report on the $27.9bn Access Control ... ...
(Date:4/4/2017)... , April 4, 2017   EyeLock LLC ... announced that the United States Patent and Trademark Office ... broadly covers the linking of an iris image with ... transaction) and represents the company,s 45 th issued ... patent is very timely given the multi-modal biometric capabilities ...
(Date:3/30/2017)... -- Trends, opportunities and forecast in this market to ... AFIS, iris recognition, facial recognition, hand geometry, vein recognition, ... industry (government and law enforcement, commercial and retail, health ... and by region ( North America , ... , and the Rest of the World) ...
Breaking Biology News(10 mins):