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Graham Hetherington Appointed Chief Financial Officer and Board Director at Shire
Date:6/10/2008

o the Shire Board. In addition to his contributions as the Company's Chief Financial Officer, he brings a wealth of financial experience as well as a new perspective from another highly competitive industry."

Graham Hetherington added:

"Shire stands out as a leader in its field because it has a differentiated model, a clear strategy and it is prepared to take calculated risks in the interest of consistently delivering growth and shareholder value. I'm pleased to be joining a company with such a track record of innovation and I'm looking forward to bringing my experience of strong consumer driven industries to the Shire organisation."

There are no details that are required to be disclosed under paragraph 9.6.13(2-6) of the UKLA Listing Rules.

Notes to Editors

SHIRE PLC

Shire's strategic goal is to become the leading specialty biopharmaceutical company that focuses on meeting the needs of the specialist physician. Shire focuses its business on attention deficit and hyperactivity disorder (ADHD), human genetic therapies (HGT), gastrointestinal (GI) and renal diseases. The structure is sufficiently flexible to allow Shire to target new therapeutic areas to the extent opportunities arise through acquisitions. Shire's in-licensing, merger and acquisition efforts are focused on products in niche markets with strong intellectual property protection either in the US or Europe. Shire believes that a carefully selected portfolio of products with strategically aligned and relatively small-scale sales forces will deliver strong results.

For further information on Shire, please visit the Company's website: http://www.shire.com.

"SAFE HARBOR" STATEMENT UNDER THE PRIVATE SECURITIES LITIGATION REFORM ACT OF 1995

Statements included herein that are not historical facts are forward-looking statements. Such forward-looking statements involve a number of risks and uncertaintie
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SOURCE Shire Ltd
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