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Government Expands Trial With IMVAMUNE(R) Smallpox Vaccine in Persons With Atopic Dermatitis/Eczema
Date:10/10/2007

persons diagnosed with atopic dermatitis.

Atopic Dermatitis Prevalence and Smallpox Vaccination

A review by medical specialists investigating the risk to persons with atopic dermatitis for developing serious side effects from traditional smallpox vaccines, suggests that up to half of the U.S. population could be at risk to the vaccine. The authors note that the lifetime prevalence of atopic dermatitis is approximately 10%-15% of the population and estimate that the same amount of people has a history of the condition(s). They further project that it is probable that twice this amount of people have contact with others who have an active case or history of atopic dermatitis, suggesting the possibility that up to half of the population could be at risk to developing complications from vaccination with or exposure to traditional smallpox vaccines.(1)

The most recent report of accidental exposure to the smallpox vaccine was the highly-publicized case of a two-year-old boy with a history of eczema that developed a serious reaction after coming in contact with the vaccinia virus from his father's smallpox vaccination.(2)

Government Guidance - Atopic Dermatitis and Smallpox Vaccination

According to the Centers for Disease Control and Prevention (CDC) persons with atopic dermatitis as well as those who have had it in the past should not receive the current smallpox vaccine because of the risk of developing severe adverse reactions to the replicating virus found in the vaccine. Additionally, due to the risk of accidental exposure to the vaccine, persons with individuals in their households with atopic dermatitis are also advised not to be given the smallpox vaccine.(3)

Bavarian Nordic's new, patented developmental smallpox vaccine, IMVAMUNE(R), is based on the Modified Vaccinia Ankara (MVA) virus. In contrast to traditional smallpox vaccines, MVA is a live virus that does not replicate in human cells which means that the potential for adve
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SOURCE Bavarian Nordic A/S
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