Navigation Links
Glowing zebrafish help researchers track role of sugars in the cell
Date:5/5/2008

culty affiliate of the California Institute for Quantitative Biosciences (QB3) and the T.Z. and Irmgard Chu Distinguished Professor of Chemistry at UC Berkeley.

"We have genes in our body coding for proteins, but proteins get modified in lots of different ways, one of which is by addition of sugars that stick out on the cell surface and change the way the protein interacts with the environment," Amacher said. "One of the big mysteries is how the pattern of sugar modification changes during development, or in cancer cells versus non-cancer cells, for example. The exciting work Carolyn is now doing is finding ways that we can actually see the sugar labels on proteins."

Scientists have known for more than a century how to attach fluorescent dyes to proteins, and have used the technique to study protein trafficking in cell culture and even in whole organisms, though often at the expense of killing the cells or organism. Bertozzi has focused on making it just as easy to study the sugars on cells, in part to investigate their role in such diseases as tuberculosis and influenza. In the latter, the flu virus enters cells by way of hemagglutinin, a sugar-protein complex on the viral surface that attaches to sugars on the surface of host cells. But sugars clearly have roles in cell-to-cell communication that have yet to be discovered.

One technique Bertozzi has developed is to feed cells an artificial sugar that looks so much like the real thing that cells are tricked into incorporating the sugar into their carbohydrate chains. Once the sugar becomes part of the forest of carbohydrates adorning a living cell, she then uses a non-toxic chemical reaction to attach small organic labels to it. Simple, highly selective and non-toxic chemical reactions like this have come to be called click chemistry.

In their work on zebrafish, Baskin, Bertozzi and their colleagues soaked zebrafish embryos in the artificial sugar N-azidoacetylgalactosamine, whic
'/>"/>

Contact: Robert Sanders
rsanders@berkeley.edu
510-643-6998
University of California - Berkeley
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. Researchers develop method for transmitting medical images via cell phones
2. Researchers create the first thermal nanomotor in the world
3. U-Md. Researchers Report Advance in Biological Microfactories for Drug Research
4. Boston College, MIT researchers achieve dramatic increase in thermoelectric efficiency
5. Iowa State researchers developing system to efficiently convert biomass to ethanol
6. Researchers engineer new polymers to change their stiffness and strength when exposed to liquids
7. Sigma-Aldrich Announces New Prestige Antibodies(TM) Line for Proteomics and Cell Biology Researchers
8. Stanford researchers hear the sound of quantum drums
9. Researchers at Leeds mine the Terahertz gap
10. Researchers create gold aluminum, black platinum, blue silver
11. Researchers Pinpoint Best Treatment to Reduce Deadly USA300, MRSA Staph Infections
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/24/2014)... GMO corn cases filed across the United States, ... of being consolidated in a Kansas federal court for pretrial ... 162 Corn Litigation, MDL No. 2591 in the U.S. District ... Syngenta GMO corn multidistrict litigation (MDL) has been handed over ...
(Date:12/24/2014)... BOSTON, MA (PRWEB) December 23, 2014 ... series is designed to introduce cutting edge communication ... partners of platform upgrades. This webinar series demonstrates ... their quest to leverage web conferencing’s most innovative ...
(Date:12/24/2014)... Island, New York (PRWEB) December 23, 2014 ... and the Long Island Affiliate of ITRA Global, the national ... slow but steady recovery. This is evidenced by the ... the strong stock market. Low energy costs have held ...
(Date:12/24/2014)... (PRWEB) December 23, 2014 Nashville Fertility Center ... treasurer for the American Society for Reproductive Medicine (ASRM), a ... reproductive medicine. In his new role as treasurer, Dr. ... will have a voice in furthering the mission of ASRM. ...
Breaking Biology Technology:Carey Danis & Lowe Reports on Syngenta GMO Corn Transfer Order 2SoundConnect Launches Leading Edge Business Communications Webinar Series 2SoundConnect Launches Leading Edge Business Communications Webinar Series 3ITRA Global Reports Long Island Is Out of Sync With The National Office Market 2ITRA Global Reports Long Island Is Out of Sync With The National Office Market 3Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 2Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 3
... , CRACKS AMAZON.COM BEST SELLER LIST IN SCIENCE , ... best selling science books , SEATTLE, Nov. 17 Despite ... about the controversial theory of intelligent design made Amazon.com,s list of ... world marks 150 years since Charles Darwin published his own theory ...
... ... Readers, Choice Award for Best Application of Green Computing. The award was presented ... in Portland, Ore. , ... Portland, OR (Vocus) Nov. 17, 2009 --- The U.S. Department of Energy,s (DOE) ...
... , SOLANA BEACH, Calif. and HAMILTON, New Zealand, Nov. ... enzyme-based products for DNA extraction and other life sciences ... note documenting that its forensic GEM(®) Saliva DNA ... high-quality, ready-to-analyze DNA from buccal swab samples compatible with ...
Cached Biology Technology:Intelligent Design Book Delivers Blow to Darwin 2Argonne Recognized for "Green Computing" in 2009 HPCwire Readers' and Editors' Choice Awards 2Argonne Recognized for "Green Computing" in 2009 HPCwire Readers' and Editors' Choice Awards 3Argonne Recognized for "Green Computing" in 2009 HPCwire Readers' and Editors' Choice Awards 4Forensic Scientists at Kansas City Crime Lab Release Validation Report Confirming Zygem's forensicGEM(R) Kit is a Reliable, Rapid Method for Extracting DNA From Saliva 2Forensic Scientists at Kansas City Crime Lab Release Validation Report Confirming Zygem's forensicGEM(R) Kit is a Reliable, Rapid Method for Extracting DNA From Saliva 3Forensic Scientists at Kansas City Crime Lab Release Validation Report Confirming Zygem's forensicGEM(R) Kit is a Reliable, Rapid Method for Extracting DNA From Saliva 4
(Date:1/22/2015)... Showcase, Hall E -   EyeLock Inc. , a market ... showcase its EyeLock ID technology integrated in a 3D printed ... Oak Ridge National Laboratory (ORNL) at the 2015 ... technology is being used to validate the driver and authorize ...
(Date:1/22/2015)... Report Issued by Small Cap IR. In 2011, Nilson Report,s ... at merchants on the leading payment cards rose to $135.3 ... and prepaid cards reached 6.54 billion.  Eight million credit card ... in 2012, and credit and debit card fraud resulted in ...
(Date:12/24/2014)... its launch in December 2014, the 1U™ app ... trying to remember their usernames and passwords through replacing the ... To assist people who have struggled to remember usernames and ... and focuses on redefining identity, announced today that it is ...
Breaking Biology News(10 mins):EyeLock Debuts First Iris Authentication Technology Embedded in 3D Printed Automobile 2EyeLock Debuts First Iris Authentication Technology Embedded in 3D Printed Automobile 3$4.80 Near Term Price Target with "Buy" given by CapRock Research for NXT-ID, Inc. (NASDAQ: NXTD) issued by Small Cap IR 21U Offers Best Solution to the Username / Password Dilemma: For FREE! 21U Offers Best Solution to the Username / Password Dilemma: For FREE! 3
... As if being admitted to the hospital werent bad ... becoming infected with a superbug bacterium, Clostridium difficile (C. ... intestinal cells by causing them to burst open, allowing ... in severe diarrhea and, in rare cases, death. Abraham ...
... Weinheim, September 04, 2007 - The term "biotechnology" elicits a ... hostility. Alan McHughen from the University of California in Riverside ... knowledge of biotech, popular misperceptions, scientific illiteracy and the role ... US and Europe" Who benefits from agricultural biotech only ...
... In the dynamic world of the developing brain, neural stem ... ventricles. These newborn neurons then migrate along the stem cell ... functions. Now, scientists have discovered a key mechanism of this ... in other developmental processes and diseases, including cancer. ...
Cached Biology News:Curbing C. difficile's toxin production 2How the public perceives biotech 2Neural stem cell study reveals mechanism that may play role in cancer 2Neural stem cell study reveals mechanism that may play role in cancer 3Neural stem cell study reveals mechanism that may play role in cancer 4
Recognizes the VZV nucleocapsid by indirect immunofluorescence and immunoprecipitation. Shows cross-reactivity to HSV....
Mouse monoclonal [11C9] to Zeralenone ( Abpromise for all tested applications). Antigen: Chemical / Small Molecule conjugated to BSA: Zeralenone...
AK6 Antibody...
...
Biology Products: