Navigation Links
Glowing zebrafish help researchers track role of sugars in the cell
Date:5/5/2008

culty affiliate of the California Institute for Quantitative Biosciences (QB3) and the T.Z. and Irmgard Chu Distinguished Professor of Chemistry at UC Berkeley.

"We have genes in our body coding for proteins, but proteins get modified in lots of different ways, one of which is by addition of sugars that stick out on the cell surface and change the way the protein interacts with the environment," Amacher said. "One of the big mysteries is how the pattern of sugar modification changes during development, or in cancer cells versus non-cancer cells, for example. The exciting work Carolyn is now doing is finding ways that we can actually see the sugar labels on proteins."

Scientists have known for more than a century how to attach fluorescent dyes to proteins, and have used the technique to study protein trafficking in cell culture and even in whole organisms, though often at the expense of killing the cells or organism. Bertozzi has focused on making it just as easy to study the sugars on cells, in part to investigate their role in such diseases as tuberculosis and influenza. In the latter, the flu virus enters cells by way of hemagglutinin, a sugar-protein complex on the viral surface that attaches to sugars on the surface of host cells. But sugars clearly have roles in cell-to-cell communication that have yet to be discovered.

One technique Bertozzi has developed is to feed cells an artificial sugar that looks so much like the real thing that cells are tricked into incorporating the sugar into their carbohydrate chains. Once the sugar becomes part of the forest of carbohydrates adorning a living cell, she then uses a non-toxic chemical reaction to attach small organic labels to it. Simple, highly selective and non-toxic chemical reactions like this have come to be called click chemistry.

In their work on zebrafish, Baskin, Bertozzi and their colleagues soaked zebrafish embryos in the artificial sugar N-azidoacetylgalactosamine, whic
'/>"/>

Contact: Robert Sanders
rsanders@berkeley.edu
510-643-6998
University of California - Berkeley
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. Researchers develop method for transmitting medical images via cell phones
2. Researchers create the first thermal nanomotor in the world
3. U-Md. Researchers Report Advance in Biological Microfactories for Drug Research
4. Boston College, MIT researchers achieve dramatic increase in thermoelectric efficiency
5. Iowa State researchers developing system to efficiently convert biomass to ethanol
6. Researchers engineer new polymers to change their stiffness and strength when exposed to liquids
7. Sigma-Aldrich Announces New Prestige Antibodies(TM) Line for Proteomics and Cell Biology Researchers
8. Stanford researchers hear the sound of quantum drums
9. Researchers at Leeds mine the Terahertz gap
10. Researchers create gold aluminum, black platinum, blue silver
11. Researchers Pinpoint Best Treatment to Reduce Deadly USA300, MRSA Staph Infections
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... Green & Grow Inc. (GGI) has raised ... secured Otter Capital as a significant new partner. Otter ... GGI’s Agriplier™ technology, building on recent compelling field trial ... first meeting, we have been impressed with Otter Capital’s ... Alan Sobba, President and CEO of GGI. “We look ...
(Date:8/27/2014)... 2014 Reportlinker.com announces that a ... its catalogue: Global Biodegradable Packaging ... http://www.reportlinker.com/p02316661/Global-Biodegradable-Packaging-Materials-Market-2014-2018.html About Biodegradable Packaging ... readily decomposed by the action of microorganisms. ... in terms of raw materials, production technology, ...
(Date:8/27/2014)... (PRWEB) August 27, 2014 The Global ... in-depth study on the current state of the Trifluoroacetic ... provides a basic overview of the industry, including definitions, ... Chinese domestic market analysis are provided with a focus ... market. A comparison between the international and Chinese situation ...
(Date:8/27/2014)... ANGELES , Aug. 27, 2014  Lisa Kulik ... years this July 4 holiday, thanks to a groundbreaking ... Ph.D., an internationally renowned clinician-researcher at the University of ... a 55-year-old Peoria, Ariz. resident ... robs its victims of sight. On June 2, she ...
Breaking Biology Technology:Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 2Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 3Global Biodegradable Packaging Materials Market 2014-2018 2Global Biodegradable Packaging Materials Market 2014-2018 3Global Biodegradable Packaging Materials Market 2014-2018 4Global Biodegradable Packaging Materials Market 2014-2018 5Global Biodegradable Packaging Materials Market 2014-2018 6Global Biodegradable Packaging Materials Market 2014-2018 7Trifluoroacetic Acid Industry (Asia, Europe, North America, ROW) Analysis Report Now Available at ReportsnReports.com 2USC Eye Institute ophthalmologists implant first FDA-approved Argus II retinal prosthesis in western United States 2USC Eye Institute ophthalmologists implant first FDA-approved Argus II retinal prosthesis in western United States 3USC Eye Institute ophthalmologists implant first FDA-approved Argus II retinal prosthesis in western United States 4USC Eye Institute ophthalmologists implant first FDA-approved Argus II retinal prosthesis in western United States 5
... France, April 23 , - ... Essilor International, the world leader in ophthalmic optics, today,announced ... 31, 2009, representing a reported 10.3% increase on the first ... the period. , Despite contracting demand ...
... RICHMOND, Calif., April 22 Sangamo BioSciences, Inc. (Nasdaq: ... will release its first quarter 2009 financial results on ... press release will be followed by a conference call ... the public via telephone and webcast. During the conference ...
... to Discuss Results to Be Held at 9:00 A.M. - ... VPHM ) first quarter financial results for 2009 are ... the open of the U.S. financial markets.The company will host ... Eastern Time on the same day. During the conference ...
Cached Biology Technology:Essilor : 2009 First Quarter Report 2Essilor : 2009 First Quarter Report 3Essilor : 2009 First Quarter Report 4Sangamo BioSciences Announces First Quarter 2009 Conference Call and Webcast 2Sangamo BioSciences Announces First Quarter 2009 Conference Call and Webcast 3ViroPharma to Release 2009 First Quarter Financial Results on April 29, 2009 2
(Date:8/28/2014)... action is needed to ensure safeguards are in place ... PLOS ONE , researchers from Monash University, Stellenbosch ... combining results from different studies - to look at ... to determine whether they actually protect biodiversity. , ... an area from human exploitation made common sense, however, ...
(Date:8/27/2014)... Most of North America,s megafauna mastodons, short-faced bears, ... horses disappeared close to 13,000 years ago at ... this massive extinction has long been debated by scientists ... , A group of scientists, including UC Santa Barbara,s ... Science, posited that a comet collision with Earth played ...
(Date:8/27/2014)... a group of fish began exploring land and evolved into ... how these ancient fish used their fishy bodies and fins ... play remain scientific mysteries. , Researchers at McGill University ... living fish, called Polypterus , to help show what ... of the water. Polypterus is an African fish ...
Breaking Biology News(10 mins):Protected areas proven to protect biodiversity 2Nanodiamonds are forever 2Nanodiamonds are forever 3Walking fish reveal how our ancestors evolved onto land 2
... of amphibians drastically decreases in forest areas that are ... researcher, however, has found that some animals may not ... may be moving away (possibly to return later) or ... both the timber industry and the survival of amphibians. ...
... changes to a gene that do not alter ... bipolar disorder. This is the first epigenome-wide investigation ... be a significant step on the journey to ... senior scientist in the Krembil Family Epigenetic Laboratory ...
... March 10 BIO-key International,Inc. (OTC Bulletin Board: BKYI) today ... results on Monday, March 17, 2008,after the market close. In ... will be broadcast live over the Internet,on Tuesday, March 18, ... BIO-key International, Inc. Fourth Quarter and Full Year 2007 ...
Cached Biology News:Amphibians respond behaviorally to impact of clear cutting 2Epigenetic changes discovered in major psychosis 2BIO-key(R) Announces Fourth Quarter and Full Year 2007 Earnings Release and Conference Call Schedule 2
... Product Goat polyclonal to Cholesterol ... Reactivity / Specificity Cross-reacts with ... Background Information Cholesterol oxidases exist ... oxidases and are implicated in bacterial pathogenesis. ...
Anti-ACTH Immunogen: Porcine ACTH conjugated to BSA. Available Date: 38566...
Goat polyclonal to XAGE1 ( Abpromise for all tested applications). Antigen: Synthetic peptide: CGFGFRRQGEDNT, corresponding to C terminal amino acids 149-160 of Human XAGE1 Entrez Gene ID: 9...
Goat polyclonal to BACE1 ( Abpromise for all tested applications). entrezGeneID: 23621 SwissProtID: P56817...
Biology Products: