Navigation Links
Glowing zebrafish help researchers track role of sugars in the cell
Date:5/5/2008

culty affiliate of the California Institute for Quantitative Biosciences (QB3) and the T.Z. and Irmgard Chu Distinguished Professor of Chemistry at UC Berkeley.

"We have genes in our body coding for proteins, but proteins get modified in lots of different ways, one of which is by addition of sugars that stick out on the cell surface and change the way the protein interacts with the environment," Amacher said. "One of the big mysteries is how the pattern of sugar modification changes during development, or in cancer cells versus non-cancer cells, for example. The exciting work Carolyn is now doing is finding ways that we can actually see the sugar labels on proteins."

Scientists have known for more than a century how to attach fluorescent dyes to proteins, and have used the technique to study protein trafficking in cell culture and even in whole organisms, though often at the expense of killing the cells or organism. Bertozzi has focused on making it just as easy to study the sugars on cells, in part to investigate their role in such diseases as tuberculosis and influenza. In the latter, the flu virus enters cells by way of hemagglutinin, a sugar-protein complex on the viral surface that attaches to sugars on the surface of host cells. But sugars clearly have roles in cell-to-cell communication that have yet to be discovered.

One technique Bertozzi has developed is to feed cells an artificial sugar that looks so much like the real thing that cells are tricked into incorporating the sugar into their carbohydrate chains. Once the sugar becomes part of the forest of carbohydrates adorning a living cell, she then uses a non-toxic chemical reaction to attach small organic labels to it. Simple, highly selective and non-toxic chemical reactions like this have come to be called click chemistry.

In their work on zebrafish, Baskin, Bertozzi and their colleagues soaked zebrafish embryos in the artificial sugar N-azidoacetylgalactosamine, whic
'/>"/>

Contact: Robert Sanders
rsanders@berkeley.edu
510-643-6998
University of California - Berkeley
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. Researchers develop method for transmitting medical images via cell phones
2. Researchers create the first thermal nanomotor in the world
3. U-Md. Researchers Report Advance in Biological Microfactories for Drug Research
4. Boston College, MIT researchers achieve dramatic increase in thermoelectric efficiency
5. Iowa State researchers developing system to efficiently convert biomass to ethanol
6. Researchers engineer new polymers to change their stiffness and strength when exposed to liquids
7. Sigma-Aldrich Announces New Prestige Antibodies(TM) Line for Proteomics and Cell Biology Researchers
8. Stanford researchers hear the sound of quantum drums
9. Researchers at Leeds mine the Terahertz gap
10. Researchers create gold aluminum, black platinum, blue silver
11. Researchers Pinpoint Best Treatment to Reduce Deadly USA300, MRSA Staph Infections
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... The overall research objective was to ... and use. Most researchers outsource NGS technologies; however, ... within the next 12 months. Data accuracy and ... sequencing instruments. Disease-related research is the dominant use ... to surge, with half of the respondents planning ...
(Date:9/30/2014)... MA (PRWEB) September 30, 2014 ... (UC) and collaboration company is dedicated to supporting ... connectivity needs. Julie Power, a carrier ... to ensure collaboration solutions stays connected and productive ... to the increased movement of businesses to cloud ...
(Date:9/30/2014)... 30, 2014 UFP Technologies, a ... packaging has recently introduced a custom insulated shipping ... . The new insulated shipper solves the issue ... process. UFP Technologies’ BioShell is a universal storage ... storage, handling and shipping. The insulated shipper keeps ...
(Date:9/30/2014)... September 30, 2014 The ... IACRN), a non-profit organization based in Pittsburgh, Pennsylvania, ... and Safety (ACRES), a Massachusetts non-profit charitable ... alliance agreement, setting the stage for multiple collaborative ... clinical research quality and safety through specialized nursing ...
Breaking Biology Technology:Global Next-generation Sequencing Trends 2SoundConnect Expands Carrier Services Division 2UFP Technologies Introduces Insulated Shipping Container For Bulk Drug Transportation 2UFP Technologies Introduces Insulated Shipping Container For Bulk Drug Transportation 3IACRN and ACRES to Support Clinical Research Nurses 2IACRN and ACRES to Support Clinical Research Nurses 3
... Calif., Sept. 21 VaxGen,Inc. (Pink Sheets: VXGN) ... and Exchange Commission (SEC) its Quarterly Report on ... The report can be found at the link,titled ... VaxGen,s web site,at http://www.vaxgen.com . (Logo: ...
... for marketing, NEW YORK, Sept. 21 Small ... and education for the,small bone and joint sector of ... been cleared by the FDA for marketing in the ... implanted, degradable,spacers to four applications with two others planned ...
... Inc. (Nasdaq:,CEPH) today announced that it has submitted ... and Drug Administration (FDA) requesting approval of,TREANDA(R) (bendamustine ... leukemia (CLL). CLL is a slowly progressing blood ... cases diagnosed every year in,the United States, according ...
Cached Biology Technology:VaxGen Files First Quarter 2007 Financials 2Small Bone Innovations Introduces the Artelon(R) STT Spacer to Increase Treatment Options for Thumb Arthritis 2Small Bone Innovations Introduces the Artelon(R) STT Spacer to Increase Treatment Options for Thumb Arthritis 3Small Bone Innovations Introduces the Artelon(R) STT Spacer to Increase Treatment Options for Thumb Arthritis 4Small Bone Innovations Introduces the Artelon(R) STT Spacer to Increase Treatment Options for Thumb Arthritis 5Cephalon Submits New Drug Application for TREANDA for the Treatment of Chronic Lymphocytic Leukemia 2Cephalon Submits New Drug Application for TREANDA for the Treatment of Chronic Lymphocytic Leukemia 3Cephalon Submits New Drug Application for TREANDA for the Treatment of Chronic Lymphocytic Leukemia 4
(Date:9/29/2014)... A University of Texas at Arlington research team says ... built in their lab could open doors for homeland ... be published in the Oct. 1 issue of ... and his co-authors describe a new method to fabricate ... and oxygen until a transparent ceramic is formed. ...
(Date:9/29/2014)... $6 million grant for clinical research and education ... safe and effective treatments for cocaine addiction. , ... of Health, National Institute on Drug Abuse, will ... Cocaine Use Disorder to oversee preclinical and early ... forward with more expensive large-scale clinical trials. , ...
(Date:9/29/2014)... For decades, planetary geologists have speculated that glaciers ... 2000-mile-long chasm that constitutes the Grand Canyon of ... that might have been carved by past glaciers ... observations have remained highly controversial and contested. ... College and the Freie Universitaet Berlin has identified ...
Breaking Biology News(10 mins):UT Arlington researchers develop new transparent nanoscintillators for radiation detection 2UT Arlington researchers develop new transparent nanoscintillators for radiation detection 3New VCU center to target cocaine addiction 2Glaciers in the Grand Canyon of Mars? 2Glaciers in the Grand Canyon of Mars? 3Glaciers in the Grand Canyon of Mars? 4Glaciers in the Grand Canyon of Mars? 5Glaciers in the Grand Canyon of Mars? 6Glaciers in the Grand Canyon of Mars? 7Glaciers in the Grand Canyon of Mars? 8Glaciers in the Grand Canyon of Mars? 9
... bacteria to become resistant to antibiotics as well as ... January issue of Microbiology . The findings could ... is managed in hospital settings. Researchers from the ... adding increasing amounts of disinfectant to laboratory cultures of ...
... first time that insects, like mammals, use vision rather than ... high-speed video cameras technology the BBC uses to capture ... desert locusts stepping along the rungs of a miniature ladder. ... perform complex tasks, such as visually-guided limb control, usually associated ...
... study recently completed in the gulf coast of Alaska by ... disappears, the production and export of high- quality food from ... could have serious consequences for marine food webs. , The ... matter to the marine environment," was recently published in the ...
Cached Biology News:Disinfectants may promote growth of superbugs 2Ladder-walking locusts show big brains aren't always best 2Glacial watersheds may contribute to oceanic food web 2
TNM-FH Insect Medium 1 liter...
IHC Polymer Detection Kit (Rabbit DAB)150 slides...
Performance, mycoplasma, virus, and endotoxin tested. Collected from calves 14 days old or less...
... PureLink PCR Purification Kits provide rapid ... enzymes, short-failed PCR products, and salts from ... bind/wash/elute procedure:, provides two Binding Buffer ... bp* , can be performed in either ...
Biology Products: