Navigation Links
Glowing Cornell dots -- a potential cancer diagnostic tool set for human trials
Date:6/13/2011

NEW YORK The U.S. Food and Drug Administration (FDA) has approved the first clinical trial in humans of a new technology: Cornell Dots, brightly glowing nanoparticles that can light up cancer cells in PET-optical imaging.

A paper describing this new medical technology, "Multimodal silica nanoparticles are effective cancer-targeted probes in a model of human melanoma," will be published June 13, 2011 in the Journal of Clinical Investigation (July 2011). This is a collaboration between Memorial Sloan-Kettering Cancer Center (MSKCC), Cornell University, and Hybrid Silica Technologies, a Cornell business start-up.

For the first time, scientists report a uniquely advanced and comprehensive characterization of Cornell Dots an ultra small, cancer-targeted, multimodal silica nanoparticle which has recently been approved as an "investigational new drug" (IND) by the FDA for a first-in-human clinical trial, says Michelle S. Bradbury, M.D., of the Memorial Sloan-Kettering Cancer Center and an assistant professor of radiology at Weill Cornell Medical College.

Cornell Dots are silica spheres less than 8 nanometers in diameter that enclose several dye molecules. (A nanometer is one-billionth of a meter, about the length of three atoms in a row.) The silica shell, essentially glass, is chemically inert and small enough to pass through the body and out in the urine. For clinical applications, the dots are coated with polyethylene glycol (PEG) so the body will not recognize them as foreign substances.

A guiding light within the body: To make the dots stick to tumor cells, organic molecules that bind to tumor surfaces or even specific locations within tumors can be attached to the PEG shell. When exposed to near-infrared light, the dots fluoresce much brighter than dye to serve as a beacon to identify the target cells. The technology, the researchers say, enables visualization during surgical treatment, showing invasive or metastati
'/>"/>

Contact: Blaine Friedlander
bpf2@cornell.edu
607-254-8093
Cornell University
Source:Eurekalert

Page: 1 2

Related biology technology :

1. Polycystic Kidney Disease Assay at Cornell University Uses Transgenomics Surveyor Nuclease & WAVE Technology
2. Gamida Cell Announces Feasibility Study With Weill Cornell Medical College
3. Under new leadership, Kavli Institute at Cornell evolves from a think tank to a proving ground
4. John Grisham Joins Focused Ultrasound Surgery Foundation Board, Citing Novel Technologys Potential to Help Millions of Patients
5. Self-assembling polymer arrays improve data storage potential
6. Rosetta Genomics and the National Institute of Health (NIH) to Identify Potential MicroRNA Drug Targets for HIV
7. CV Therapeutics Initiates Phase 1 Clinical Trial of CVT-3619, a Novel Potential Treatment for Cardiometabolic Diseases
8. Insmed and Premacure Cite Study Results Demonstrating Potential Effectiveness of IPLEX(TM) in Preventing Blindness in Premature Infants
9. CPC of America, Inc. to Explore Strategic Alternatives; Appoints FTI Capital Advisors to Assess Potential Opportunities
10. Jellyfish Protein Shows Potential to Help With Memory
11. Innovation and Strong Therapeutic Potential Seen in Adult Stem Cells, According to Frost & Sullivan
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/15/2014)... Scottsdale, Arizona (PRWEB) January 15, 2014 ... innovation and growth for Scottsdale’s Brain State Technologies®. ... team at Wake Forest University Medical Center who ... Susanne Marcus Collins Foundation, had research papers published ... Amy Grant highlighted Brainwave Optimization® in First for ...
(Date:1/15/2014)... (PRWEB) January 15, 2014 AudioNotch ... an experimental new therapy for the treatment of tinnitus. ... for their unique tinnitus frequency, and over a period ... AudioNotch has previously provided Notched Sound Therapy in two ... is pleased to announce to release of a new ...
(Date:1/14/2014)... Date: Friday, April 11, 2014 , ... Country Club, 1360 Almshouse Road, Warrington, Pa. ... nonprofit organization solely dedicated to finding a cure for ... those affected worldwide, will host its annual Crystal Ball ... Warrington, Pa. , Each year, the Crystal Ball ...
(Date:1/14/2014)... Diego, CA (PRWEB) January 14, 2014 ... solutions based on the products of cells grown ... have entered into an international license agreement with ... Histogen’s proprietary multipotent cell conditioned media (CCM). ... the existing license between Histogen and Suneva Medical, ...
Breaking Biology Technology:Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3Hepatitis B Foundation to Host Annual Crystal Ball Gala 2Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 2Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 3
... ... of Chronic Wounds, ... focused on improving patient quality of life, today,announced that its ... KFH Novo medical device, a breakthrough medical,technology that enhances the ...
... 11 Anadys Pharmaceuticals,Inc. (Nasdaq: ANDS ) announced ... 28th Annual Healthcare Conference on Tuesday, March 18, 2008 ... being held at the Boston,Marriot Copley Place., Steve ... Inc., will present an overview of Anadys and its ...
... 11 Nile Therapeutics,Inc. (OTC Bulletin Board: NILT), today ... financial results for 2007 after the market,closes on Thursday, ... and live webcast to discuss these financial results and ... 4:30 p.m. ET, 1:30 p.m. PT,that afternoon., Interested ...
Cached Biology Technology:Kingfisher Healthcare Receives European CE Mark for Next Generation Wound Healing Device 2Anadys Pharmaceuticals to Present at the Cowen and Company Healthcare Conference 2Nile Therapeutics to Announce 2007 Fourth Quarter and Full Year Financial Results on Thursday, March 13, 2008 2
(Date:4/15/2014)... Puerto Rican community is creating a tropical home away ... has caught the attention of scientists. David W. Taylor ... Connecticut) took a close look at the fresh crops ... evidence that gives new meaning to a phrase that ... in the kitchen. , "Culinary preferences tell us a ...
(Date:4/15/2014)... University of Missouri researchers have previously shown that a ... exercise exists. In a new study, Frank Booth, a ... found a potential link between the genetic pre-disposition for ... which mental maturation occurs. , For his study, Booth ... activity or extreme laziness. Booth then put the rats ...
(Date:4/15/2014)... Case Western Reserve University dental researchers have found ... immune cells from the mouth to study how ... inflammation. , By isolating some specialized immune cells ... how they fight diseases in the mouthor reject ... hope to learn more about treating and preventing ...
Breaking Biology News(10 mins):The human food connection: A new study reveals more about our relationship to food 2The human food connection: A new study reveals more about our relationship to food 3Genetic pre-disposition toward exercise and mental development may be linked 2New method isolates immune cells for researchers to study how they ward off oral diseases 2
... been named as one of the 2008 Environmental Scientists ... His half-brother, biologist Jules Blais, is the other winner ... prestigious in the environmental sciences. The prize recognizes the ... Smol is series editor of the Springer ...
... 2 BIO-key International,Inc. (OTC Bulletin Board: BKYI), ... identification solutions, today announced that it,has been awarded ... with a large multi-national technology company. BIO-key will,license ... be used on,multiple, large international and domestic opportunities., ...
... WI, JUNE 2, 2008-- An understanding how environmental ... transport and fate of agricultural chemicals in the ... degradation of surface and ground waters from past, ... has been conducted at field or smaller scales, ...
Cached Biology News:BIO-key(R) Awarded $2 Million Biometric Contract by Multi-National Company 2Holistic understanding: Ag chemicals in the environment 2
... requiring mass detection but not structural ... Mass spectrometer is ideally suited for ... high performance mass analysis. Typical ... protein detection, micro-satellite DNA characterization and ...
Rat Lung Fibroblasts (RLF) (>500,000 cells)...
... ideal small concentrator for the molecular biology ... water and organic solvents from a variety ... and round bottom flasks. Making it an ... ,The built-in special runs for working with ...
... suitable for use with a wide range ... to water and some of the higher ... of removing water and organic solvents from ... microplates, vials and round bottom flasks; making ...
Biology Products: