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Global Study Shows That Majority of Women with Osteoporosis Do Not Consider Themselves at Higher Risk for Fractures
Date:9/15/2008

nd undertreated," said Cyrus Cooper, M.D., GLOW investigator and Director of the MRC Epidemiology Resource Centre, University of Southampton, and Norman Collison Chair of Musculoskeletal Sciences, University of Oxford, United Kingdom. "We hope that GLOW will highlight the deep impact that a fracture can have on a patient's life and create an awareness among health professionals that preventive therapy should be commenced urgently in patients with osteoporotic fractures."

Study Details

GLOW is a prospective, longitudinal, observational study of women 55 years of age and older who visited a primary care physician during the two years prior to the study. Over 60,000 women have been recruited through over 700 primary care physicians in 17 cities in the United States, Canada, Europe, and Australia. GLOW is gathering information on osteoporosis risk factors, treatment approaches, patient behaviour, and fracture outcomes with an annual patient survey over a 5 year period.

Self-perceived risk of fracture was assessed using a five-point scale ranging from "much lower" to "much higher" risk than other women of the same age. Of 60,112 patients, 11,276 reported an osteoporosis diagnosis.

Data on the occurrence of fracture since the age of 45 years was collected for 10 skeletal sites (spine, ankle, arm, collarbone, hip, pelvis, rib, wrist, and upper and lower leg). Fracture history was correlated to a patient's health-related quality of life as measured by EuroQoL EQ-5D,(4) an instrument that assesses health in the areas of mobility, self-care, usual activities of daily living, pain, and depression. The score is expressed as a health utility score, 1 representing perfect health and 0 representing death. Patients completing all of the EQ-5D questions (56,866) were included in the analysis. Mean EQ-5D scores were significantly higher in women with no fractures versus those with one or multiple fractures since the age of 45 years (0.78 vs. 0.74 and 0.65,
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SOURCE University of Massachusetts Medical School
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