GLOW is a prospective, longitudinal, observational study of women 55 years of age and older who visited a primary care physician during the two years prior to the study. Over 60,000 women have been recruited through over 700 primary care physicians in 17 cities in the United States, Canada, Europe, and Australia. GLOW is gathering information on osteoporosis risk factors, treatment approaches, patient behaviour, and fracture outcomes with an annual patient survey over a 5 year period.
Self-perceived risk of fracture was assessed using a five-point scale ranging from "much lower" to "much higher" risk than other women of the same age. Of 60,112 patients, 11,276 reported an osteoporosis diagnosis.
Data on the occurrence of fracture since the age of 45 years was
collected for 10 skeletal sites (spine, ankle, arm, collarbone, hip,
pelvis, rib, wrist, and upper and lower leg). Fracture history was
correlated to a patient's health-related quality of life as measured by
EuroQoL EQ-5D,(4) an instrument that assesses health in the areas of
mobility, self-care, usual activities of daily living, pain, and
depression. The score is expressed as a health utility score, 1
representing perfect health and 0 representing death. Patients completing
all of the EQ-5D questions (56,866) were included in the analysis. Mean
EQ-5D scores were significantly higher in women with no fractures versus
those with one or multiple fractures since the age of 45 years (0.78 vs.
0.74 and 0.65,
|SOURCE University of Massachusetts Medical School|
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