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Global Molecular Cytogenetics Industry
Date:9/8/2011

enetics 34

Benefits of CGH Analysis in Clinical Genetics 34

Limitations of CGH 35

Advent of Microarray Technology 35

What are Microarrays? 35

Microarrays in Gene Expression Analysis 35

Microarrays in Comparative Genomic Hybridization 36

Principle Underlying aCGH 36

Low Resolution and High Resolution aCGH 37

ACGH: The Process 37

aCGH: Potential Uses and Limitations 37

Potential Advantages of aCGH could be summarized as below 37

Limitations of aCGH 38

Analytical and Post-analytical Limitations 38

Interpretation of Results 38

Applications of aCGH 38

A Review of Molecular Biology Techniques in Cytogenetics 39

4. RECENT INDUSTRY ACTIVITY 41

Agilent and Kreatech Enter into New License and Supply Deal 41

Clarient to Commercialize CombiMatrix's Genomic Profile Tests

for Cancer 41

Kreatech Inks License Agreement with Veridex to Use Repeat-

Free™ Technology 41

PerkinElmer to Acquire Signature Genomic Laboratories 42

Illumina to Submit Micro-Array based iscan Technology to the

US FDA through Pre-IDE Process 42

Invitrogen Announces Merger with Applied Biosystems 42

LabCorp to Use GeneChip Technology of Affymetrix 43

Dako Denmark Receives FDA Approval for TOP2A FISH pharmDx Device 43

Abbott Partners with Roche, OSI and Genentech 43

5. PRODUCT LAUNCHES 44

BlueGnome Rolls Out CytoChip Cancer 44

PerkinElmer Introduces Prenatal BACs-on-Beads™ Assay in Europe 44

Agilent Introduces New SNP Probes for SurePrint G3 Human CGH

Platform 44

Affymetrix Launches Two Novel Microarrays for Cytogenetics 45

Roche Applied Science Introduces NimbleGen CGX 45

Gastrocor Launches GastroFISH 46

Roche NimbleGen Introduces New Probe Arrays 46

Ambry Genetics Launches Whole-Genome Chromosomal Microarray

Analysis 46


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