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Global Molecular Cytogenetics Industry
Date:9/8/2011

3D-FISH 4

Cellular Compartment Analysis of Temporal Activity 4

Combined Binary Ratio-FISH 4

Cryo-FISH 5

Immuno-FISH 5

Quantum Dot-Conjugates-FISH 5

Array-based Technology 5

Microarrays in Comparative Genomic Hybridization 5

2. INDUSTRY OVERVIEW 7

Advances in Molecular Biology Techniques Broaden the Scope of

Cytogenetics 7

FISH: The Leading Technology in Biomedical Research 7

Molecular Cytogenetics to Advance Gene-Level Disease

Management in Oncology 8

Diverse Applications of FISH Technology in Oncology 9

Array Based Technologies To Drive Significant Market Growth 9

Transition from FISH to Array Based Technologies: A Major Trend 9

Array-based CGH to Emerge as First Line Test for Clinical

Diagnosis of Chromosomal Anomalies 10

Market Outlook 10

Molecular Cytogenetics Find Increasing Penetration in

Clinical Pathological Testing 10

Enhanced AP LIS a Must to Keep Pace with Advancing Molecular

Cytogenetic Testing 11

Impact of Shifting Focus of Biopharmaceuticals from Research

to Development on Microarray Technology 11

Next-Gen Sequencing to Challenge Microarray Technology in the

Distant Future 11

3. TECHNOLOGY OVERVIEW 13

A Preface to Cytogenetics 13

Basic Terms and Definitions in Molecular Biology 13

DNA and RNA 13

RNA (Ribose nucleic acid) 14

Chromosomes 14

Gene 15

Genotype 15

Phenotype 15

Haplotype 15

Karyotyping 15

Karyotype 15

Nick 16

Probe 16

Reporter Molecule 16

Copy Number 16

Copy Number Variation 16

Analysis of Copy Numbers Variations 16

Chromosomal Abnormalities in Human Beings 16

An Overview of Select Chromosomal Anomalies 17

Insertions 17

Deletions 17

Duplication 17

Rearrangement 18

Select Human Disea
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