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Global Molecular Cytogenetics Industry
Date:9/8/2011

NEW YORK, Sept. 8, 2011 /PRNewswire/ -- Reportlinker.com announces that a new market research report is available in its catalogue:

Global Molecular Cytogenetics Industry

http://www.reportlinker.com/p0611064/Global-Molecular-Cytogenetics-Industry.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Genomics

This report analyzes the worldwide markets for Molecular Cytogenetics in US$ Million by the following technologies: Fluorescence In Situ Hybridization (FISH), and Array-based Technology. The report provides separate comprehensive analytics for the North America, Europe, and Rest of World. Annual estimates and forecasts are provided for the period 2009 through 2017. Also, a six-year historic analysis is provided for these markets. The report profiles 24 companies including many key and niche players such as Abbott Molecular Inc., Affymetrix, Inc., Applied Spectral Imaging, BI Biological Industries, Bluegnome, ltd., ChromTrax, CytoTest, Inc., Cytognomix, Inc., Illumina, Inc., Inter Medico, Kreatech Diagnostics, Life Technologies Corporation, Oxford Gene Technology, PerkinElmer, Inc., Roche NimbleGen, Inc., and SciGene Corporation. Market data and analytics are derived from primary and secondary research. Company profiles are mostly extracted from URL research and reported select online sources.

1. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS 1

Study Reliability and Reporting Limitations 1

Disclaimers 2

Data Interpretation & Reporting Level 3

Quantitative Techniques & Analytics 3

Product Definitions and Scope of Study 3

Definitions 4

Fluorescence In Situ Hybridization 4

Select FISH Procedures in Use 4

3D-FISH 4

Cellular Compartment Analysis of Temporal Activity 4

Combined Binary Ratio-FISH 4

Cryo-FISH 5

Immuno-FISH 5

Quantum Dot-Conjugates-FISH 5

Array-based Technology 5

Microarrays in Comparative Genomic Hybridization 5

2. INDUSTRY OVERVIEW 7

Advances in Molecular Biology Techniques Broaden the Scope of

Cytogenetics 7

FISH: The Leading Technology in Biomedical Research 7

Molecular Cytogenetics to Advance Gene-Level Disease

Management in Oncology 8

Diverse Applications of FISH Technology in Oncology 9

Array Based Technologies To Drive Significant Market Growth 9

Transition from FISH to Array Based Technologies: A Major Trend 9

Array-based CGH to Emerge as First Line Test for Clinical

Diagnosis of Chromosomal Anomalies 10

Market Outlook 10

Molecular Cytogenetics Find Increasing Penetration in

Clinical Pathological Testing 10

Enhanced AP LIS a Must to Keep Pace with Advancing Molecular

Cytogenetic Testing 11

Impact of Shifting Focus of Biopharmaceuticals from Research

to Development on Microarray Technology 11

Next-Gen Sequencing to Challenge Microarray Technology in the

Distant Future 11

3. TECHNOLOGY OVERVIEW 13

A Preface to Cytogenetics 13

Basic Terms and Definitions in Molecular Biology 13

DNA and RNA 13

RNA (Ribose nucleic acid) 14

Chromosomes 14

Gene 15

Genotype 15

Phenotype 15

Haplotype 15

Karyotyping 15

Karyotype 15

Nick 16

Probe 16

Reporter Molecule 16

Copy Number 16

Copy Number Variation 16

Analysis of Copy Numbers Variations 16

Chromosomal Abnormalities in Human Beings 16

An Overview of Select Chromosomal Anomalies 17

Insertions 17

Deletions 17

Duplication 17

Rearrangement 18

Select Human Diseases/Abnormalities Arising due to

Translocations 18

Molecular Cytogenetics: Definition and Scope 19

Application of Molecular Cytogenetics 19

Insight into Molecular Cytogenetics Techniques 19

Fluorescence In Situ Hybridization (FISH) 19

What is In Situ Hybridization? 19

How is FISH Better than Conventional Techniques? 21

Fluorescence In Situ Hybridization: The Process 21

Probe Types and Application 22

Types of Probes 22

Common Methods of Probe Preparation 23

Nick Translation and Polymerase Chain Reaction (PCR) 23

Applications of FISH 23

Types of FISH 23

3D-FISH 23

ACM-FISH or Multicolor FISH 24

ArmFISH 24

Catalyzed Reporter Deposition-FISH 24

Cellular Compartment Analysis of Temporal Activity 24

Cytochalasin-B -FISH 25

Combined Binary Ratio-FISH 25

Chromosome Orientation And Direction FISH 25

Combinatorial Oligonucleotide -FISH 25

Comet-FISH 26

Cryo-FISH 26

Double-Fusion -FISH 26

DNA Breakage Detection -FISH 27

e-FISH 27

Fiber-FISH 27

Flow-FISH 27

Fusion-Signal FISH 27

Halo-FISH 28

Harlequin-FISH 28

Immuno-FISH 28

Locked Nucleic Acids-FISH 28

M-FISH 29

Multilocus-FISH 29

Premature Chromosome Condensation-FISH 29

Peptide Nucleic Acids-FISH 30

Novel FISH Technology to Detect Plague Bacillus 30

Quantitative-FISH 30

Quantum Dot-Conjugates-FISH 31

Rainbow-FISH 31

Reverse-FISH 31

Recognition of Individual Genes-FISH 31

Expression-FISH 32

RxFISH 32

Split-Signal FISH 32

Telomere-FISH/ Tissue-FISH/ Tyramide-FISH (T-FISH) 32

Zoo-FISH 32

Spectral Karyotyping (SKY) Technique 33

Mouse FISH - a New Development 33

Comparative Genomic Hybridization 34

CGH: The Process 34

CGH: Applications In Clinical Cytogenetics 34

Benefits of CGH Analysis in Clinical Genetics 34

Limitations of CGH 35

Advent of Microarray Technology 35

What are Microarrays? 35

Microarrays in Gene Expression Analysis 35

Microarrays in Comparative Genomic Hybridization 36

Principle Underlying aCGH 36

Low Resolution and High Resolution aCGH 37

ACGH: The Process 37

aCGH: Potential Uses and Limitations 37

Potential Advantages of aCGH could be summarized as below 37

Limitations of aCGH 38

Analytical and Post-analytical Limitations 38

Interpretation of Results 38

Applications of aCGH 38

A Review of Molecular Biology Techniques in Cytogenetics 39

4. RECENT INDUSTRY ACTIVITY 41

Agilent and Kreatech Enter into New License and Supply Deal 41

Clarient to Commercialize CombiMatrix's Genomic Profile Tests

for Cancer 41

Kreatech Inks License Agreement with Veridex to Use Repeat-

Free™ Technology 41

PerkinElmer to Acquire Signature Genomic Laboratories 42

Illumina to Submit Micro-Array based iscan Technology to the

US FDA through Pre-IDE Process 42

Invitrogen Announces Merger with Applied Biosystems 42

LabCorp to Use GeneChip Technology of Affymetrix 43

Dako Denmark Receives FDA Approval for TOP2A FISH pharmDx Device 43

Abbott Partners with Roche, OSI and Genentech 43

5. PRODUCT LAUNCHES 44

BlueGnome Rolls Out CytoChip Cancer 44

PerkinElmer Introduces Prenatal BACs-on-Beads™ Assay in Europe 44

Agilent Introduces New SNP Probes for SurePrint G3 Human CGH

Platform 44

Affymetrix Launches Two Novel Microarrays for Cytogenetics 45

Roche Applied Science Introduces NimbleGen CGX 45

Gastrocor Launches GastroFISH 46

Roche NimbleGen Introduces New Probe Arrays 46

Ambry Genetics Launches Whole-Genome Chromosomal Microarray

Analysis 46

London Genetics Introduces New Molecular Cytogenetics Service 46

OGT Introduces Genomic DNA Labeling Kit 47

Oxford Gene Technology Introduces New Sample Tracking DNA

Labeling Kits 47

BlueGnome Introduces 24sure™ 47

6. FOCUS ON SELECT PLAYERS 48

Abbott Molecular Inc. (US) 48

Affymetrix, Inc. (US) 48

Applied Spectral Imaging (US) 49

BI Biological Industries (Israel) 49

Bluegnome, ltd. (UK) 49

ChromTrax (US) 50

CytoTest, Inc. (UK) 50

Cytognomix, Inc. (Canada) 52

Illumina, Inc. (US) 52

Inter Medico (Canada) 52

Kreatech Diagnostics (The Netherlands) 53

Life Technologies Corporation (US) 53

Oxford Gene Technology (UK) 54

PerkinElmer, Inc. (US) 54

Roche NimbleGen, Inc. (US) 55

SciGene Corporation (US) 55

7. GLOBAL MARKET PERSPECTIVE 56

Table 1: World Recent Past Current & Future Analysis for

Molecular Cytogenetics Technologies by Geographic Region -

North America, Europe, and Rest of World Independently

Analyzed with Annual Sales Figures in US$ Thousand for Years

2009 through 2017 (includes corresponding Graph/Chart) 56

Table 2: World Historic Review for Molecular Cytogenetics

Technologies by Geographic Region - North America, Europe, and

Rest of World Independently Analyzed with Annual Sales Figures

in US$ Thousand for Years 2003 through 2008 (includes

corresponding Graph/Chart) 57

Table 3: World 15-Year Perspective for Molecular Cytogenetics

Technologies by Geographic Region - Percentage Breakdown of

Dollar Sales for North America, Europe, and Rest of World for

Years 2003, 2010 & 2017 (includes corresponding Graph/Chart) 57

By Technology 58

Table 4: World Recent Past Current & Future Analysis for

Fluorescence In Situ Hybridization by Geographic Region -

North America, Europe, and Rest of World Independently

Analyzed with Annual Sales Figures in US$ Thousand for Years

2009 through 2017 (includes corresponding Graph/Chart) 58

Table 5: World Historic Review for Fluorescence In Situ

Hybridization by Geographic Region - North America, Europe,

and Rest of World Independently Analyzed with Annual Sales

Figures in US$ Thousand for Years 2003 through 2008 (includes

corresponding Graph/Chart) 59

Table 6: World 15-Year Perspective for Fluorescence In Situ

Hybridization by Geographic Region - Percentage Breakdown of

Dollar Sales for North America, Europe, and Rest of World for

Years 2003, 2010 & 2017 2010 & 2017 (includes corresponding

Graph/Chart) 59

Table 7: World Recent Past Current & Future Analysis for

Array-Based Technology by Geographic Region - North America,

Europe, and Rest of World Independently Analyzed with Annual

Sales Figures in US$ Thousand for Years 2009 through 2017

(includes corresponding Graph/Chart) 60

Table 8: World Historic Review for Array-Based Technology by

Geographic Region - North America, Europe, and Rest of World

Independently Analyzed with Annual Sales Figures in US$

Thousand for Years 2003 through 2008 (includes corresponding

Graph/Chart) 61

Table 9: World 15-Year Perspective for Array-Based Technology

by Geographic Region - Percentage Breakdown of Dollar Sales

for North America, Europe, and Rest of World for Years 2003,

2010 & 2017 (includes corresponding Graph/Chart) 61

8. NORTH AMERICA 62

A.Market Analysis 62

Market Trends 62

aCGH to Predominate the Technological Front in Molecular

Cytogenetics in Future 62

Revised ACMG Guidelines to Accelerate Use of aCGH Over

FISH in the US 62

The Clinical Sector: A Potential Market Opportunity for

Array-based Technologies 62

FISH in the Cancer Diagnostics Scenario in the US 62

Market Restraints 63

Immunohistochemical (IHC) Tests: The Most Recommended

Diagnostic Test for Cancers 63

Factors Limiting the Growth of FISH Technology in Cancer

Diagnostics 63

FISH in Diagnosis of Bladder Carcinoma 63

FISH in Breast Cancer Diagnosis 63

Table 10: Overview of Prices of Testing Products based

Various Technologies 64

Table 11: Medicare Reimbursement Provided for HER-2/Neu 64

Strategic Corporate Developments 65

Product Launches 68

Focus on Select Major Players 69

Abbott Molecular Inc. 69

Affymetrix, Inc. 70

Applied Spectral Imaging 70

ChromTrax 70

Cytognomix, Inc. 71

Illumina, Inc. 71

Inter Medico 72

Life Technologies Corporation 72

PerkinElmer, Inc. 73

Roche NimbleGen, Inc. 73

SciGene Corporation 74

B.Market Analytics 74

Table 12: North American Recent Past Current & Future

Analysis for Molecular Cytogenetics by Technology

(Fluorescence In Situ Hybridization and Array-based

Technology) Independently Analyzed with Annual Sales Figures

in US$ Thousand for Years 2009 through 2017 (includes

corresponding Graph/Chart) 74

Table 13: North American Historic Review for Molecular

Cytogenetics by Technology Type Fluorescence In Situ

Hybridization and Array-based Technology Independently

Analyzed with Annual Sales Figures in US$ Thousand for Years

2003 through 2008 (includes corresponding Graph/Chart) 75

Table 14: North American 15-Year Perspective for Molecular

Cytogenetics Market by Technology - Percentage Breakdown of

Dollar Sales for Fluorescence In Situ Hybridization and

Array-based Technology for Years 2003, 2010 & 2017 (includes

corresponding Graph/Chart) 75

9. EUROPE 76

A.Market Analysis 76

Product Launch 76

B.Market Analytics 77

Table 15: European Recent Past Current & Future Analysis for

Molecular Cytogenetics Market by Region- France, Germany,

Italy, UK, and Rest of Europe Independently Analyzed with

Annual Sales Figures in US$ Thousand for Years 2009 through

2017 (includes corresponding Graph/Chart) 77

Table 16: European Historic Review for Molecular

Cytogenetics Market by Region- France, Germany, Italy, UK,

and Rest of Europe Independently Analyzed with Annual Sales

Figures in US$ Thousand for Years 2003 through 2008

(includes corresponding Graph/Chart) 78

Table 17: European 15-Year Perspective for Molecular

Cytogenetics Market by Technology - Percentage Breakdown of

Dollar Sales for France, Germany, Italy, UK, and Rest of

Europe for Years 2003, 2010 & 2017 (includes corresponding

Graph/Chart) 79

9a. FRANCE 80

Market Analysis 80

Table 18: French Recent Past Current & Future Analysis for

Molecular Cytogenetics Market by Technology (Fluorescent In

Situ Hybridization and Array-based Technology) Independently

Analyzed with Annual Sales Figures in US$ Thousand for Years

2009 through 2017 (includes corresponding Graph/Chart) 80

Table 19: French Historic Review for Molecular Cytogenetics

Market by Technology (Fluorescent In Situ Hybridization and

Array-based Technology) Independently Analyzed with Annual

Sales Figures in US$ Thousand for Years 2003 through 2008

(includes corresponding Graph/Chart) 81

Table 20: French 15-Year Perspective for Molecular

Cytogenetics Market by Technology - Percentage Breakdown of

Dollar Sales for Fluorescent In Situ Hybridization and

Array-based Technology for Years 2003, 2010 & 2017 (includes

corresponding Graph/Chart) 81

9b. GERMANY 82

Market Analysis 82

Table 21: German Recent Past Current & Future Analysis for

Molecular Cytogenetics Market by Technology (Fluorescent In

Situ Hybridization and Array-based Technology) Independently

Analyzed with Annual Sales Figures in US$ Thousand for Years

2009 through 2017 (includes corresponding Graph/Chart) 82

Table 22: German Historic Review for Molecular Cytogenetics

Market by Technology (Fluorescent In Situ Hybridization and

Array-based Technology) Independently Analyzed with Annual

Sales Figures in US$ Thousand for Years 2003 through 2008

(includes corresponding Graph/Chart) 83

Table 23: German 15-Year Perspective for Molecular

Cytogenetics Market by Technology - Percentage Breakdown of

Dollar Sales for Fluorescent In Situ Hybridization and

Array-based Technology for Years 2003, 2010 & 2017 (includes

corresponding Graph/Chart) 83

9c. ITALY 84

Market Analysis 84

Table 24: Italian Recent Past Current & Future Analysis for

Molecular Cytogenetics Market by Technology (Fluorescent In

Situ Hybridization and Array-based Technology) Independently

Analyzed with Annual Sales Figures in US$ Thousand for Years

2009 through 2017 (includes corresponding Graph/Chart) 84

Table 25: Italian Historic Review for Molecular Cytogenetics

Market by Technology (Fluorescent In Situ Hybridization and

Array-based Technology) Independently Analyzed with Annual

Sales Figures in US$ Thousand for Years 2003 through 2008

(includes corresponding Graph/Chart) 85

Table 26: Italian 15-Year Perspective for Molecular

Cytogenetics Market by Technology - Percentage Breakdown of

Dollar Sales for Fluorescent In Situ Hybridization and

Array-based Technology for Years 2003, 2010 & 2017 (includes

corresponding Graph/Chart) 85

9d. THE UNITED KINGDOM 86

A.Market Analysis 86

Product Launches 86

Focus on Select Major Players 88

BlueGnome, Ltd. 88

CytoTest, Inc. 88

Oxford Gene Technology 89

B.Market Analytics 90

Table 27: The United Kingdom Recent Past Current & Future

Analysis for Molecular Cytogenetics Market by Technology

(Fluorescent In Situ Hybridization and Array-based

Technology) Independently Analyzed with Annual Sales Figures

in US$ Thousand for Years 2009 through 2017 (includes

corresponding Graph/Chart) 90

Table 28: The United Kingdom Historic Review for Molecular

Cytogenetics Market by Technology (Fluorescent In Situ

Hybridization and Array-based Technology) Independently

Analyzed with Annual Sales Figures in US$ Thousand for Years

2003 through 2008 (includes corresponding Graph/Chart) 91

Table 29: The United Kingdom 15-Year Perspective for

Molecular Cytogenetics Market by Technology - Percentage

Breakdown of Dollar Sales for Fluorescent In Situ

Hybridization and Array-based Technology for Years 2003,

2010 & 2017 (includes corresponding Graph/Chart) 91

9e. REST OF EUROPE 92

A.Market Analysis 92

Strategic Corporate Developments 92

Focus on Select Major Players 93

Kreatech Diagnostics 93

Roche Diagnostics, Corp. 93

B.Market Analytics 94

Table 30: Rest of European Recent Past Current & Future

Analysis for Molecular Cytogenetics Market by Technology

(Fluorescent In Situ Hybridization and Array-based

Technology) Independently Analyzed with Annual Sales Figures

in US$ Thousand for Years 2009 through 2017 (includes

corresponding Graph/Chart) 94

Table 31: Rest of European Historic Review for Molecular

Cytogenetics Market by Technology (Fluorescent In Situ

Hybridization and Array-based Technology) Independently

Analyzed with Annual Sales Figures in US$ Thousand for Years

2003 through 2008 (includes corresponding Graph/Chart) 95

Table 32: Rest of European 15-Year Perspective for Molecular

Cytogenetics Market by Technology - Percentage Breakdown of

Dollar Sales for Fluorescent In Situ Hybridization and

Array-based Technology for Years 2003, 2010 & 2017 (includes

corresponding Graph/Chart) 95

10. REST OF WORLD 96

A.Market Analysis 96

China: A Potential Market for FISH Technology in Clinical

Diagnostics 96

Table 33: Penetration of FISH in Chinese Hospitals

(2008-2012) (includes corresponding Graph/Chart) 96

Table 34: Penetration of FISH in Tier-1 Chinese Hospitals

(2008-2012) (includes corresponding Graph/Chart) 97

Table 35: Penetration of FISH in Tier-2 Chinese Hospitals

(2008-2012) 97

Table 36: Overview of Select FISH Products Offered by

Abbott and CMED: A Comparison (in RMB) (includes

corresponding Graph/Chart) 97

An Insight into the Indian Microarray Market 98

Focus on Select Major Player 98

BI Biological Industries 98

B.Market Analytics 99

Table 37: Rest of World Recent Past Current & Future

Analysis for Molecular Cytogenetics Market by Technology

(Fluorescence In Situ Hybridization and Array-based

Technology) Independently Analyzed with Annual Sales Figures

in US$ Thousand for Years 2009 through 2017 (includes

corresponding Graph/Chart) 99

Table 38: Rest of World Historic Review for Molecular

Cytogenetics Market by Technology (Fluorescence In Situ

Hybridization and Array- based Technology) Independently

Analyzed with Annual Sales Figures in US$ Thousand for Years

2003 through 2008 (includes corresponding Graph/Chart) 100

Table 39: Rest of World 15-Year Perspective for Molecular

Cytogenetics Market by Technology - Percentage Breakdown of

Dollar Sales for Fluorescent In Situ Hybridization and

Array-based Technology for Years 2003, 2010 & 2017 (includes

corresponding Graph/Chart) 100

COMPETITIVE LANDSCAPE

Total Companies Profiled: 24

------------------------------------------

Region/Country Players

------------------------------------------

The United States 15

Canada 2

Europe 6

Germany 1

The United Kingdom 2

Rest of Europe 3

Middle-East 1

------------------------------------------

To order this report:

Genomics Industry: Global Molecular Cytogenetics Industry

Genomics Business News

More  Industry Analysis and Insights

Nicolas Bombourg
Reportlinker
Email: nbo@reportlinker.com
US: (805)652-2626
Intl: +1 805-652-2626


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