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Global Genetic Engineering Industry

NEW YORK, April 26, 2012 /PRNewswire/ -- announces that a new market research report is available in its catalogue:


Global Genetic Engineering Industry


The global outlook series on Genetic Engineering provides a collection of market briefs and concise summaries of research findings. The report offers an aerial view of the industry, highlights latest developments, and discusses demand drivers, issues and concerns, and regulatory environment. Discussion on the industry's most noteworthy regional market, the US, is amply detailed with unbiased research commentary to provide the reader a rudimentary understanding of the prevailing market climate. Market discussions in the report are punctuated with fact-rich market data tables. Regional markets elaborated upon include United States, Canada, India, China, and South Africa among others. Also included is an indexed, easy-to-refer, fact-finder directory listing the addresses, and contact details of 153 companies active in the market.





Genetic Engineering: A Prelude 1

Genetic Engineering: Not the Same As Biotechnology 1

The Evolution and Progress of GM Crops 2

M Crops Gain Global Acceptance 2

GM Cultivation Gains Prominence in Developing Nations 2

Rising Prices, Food Shortage Make Biotech Grains Attractive 2

Socio-Economic Impacts of Biotech Crops 3

Impact of GM Crops on Biodiversity 3

Challenges to GM Crops Adoption 3

Biotech Regulatory Measures Hinder Crop Domestication 4

Genetic Modification of Forest Trees and Associated Issues 4

Biosafety: a Key Criterion Associated 4

Governments Not to Give Up on GM Hope 4

US - The Largest Producer of GM Crops 5

Leading Countries by Biotech Crop Area (2009) 5

Table 1: Current and Future Analysis of the Global Biotech

Crops Market By Geographic Region for the US, Canada,

Asia-Pacific, Latin America and Rest of World Independently

Analyzed with Annual Sales Figures in US$ Million for 2010

through 2015 6

Major Market Participants 7



Global Food Demand to Drive Need for GM Crops 8

Developing Countries: Major Share Holders for Biotech Crop

Production 8

Status of Biotech Rice in the World 8

Genetic Engineering - A Solution for Food Crisis! 9

Harmful or Healthy: Breaking The Myth About GM Crops 9

Non-food Sectors to Benefit from GE Technology 9

Genetic Engineering and Enzymes 9

GE to Help Starch and Sugar Processing Enzyme Market 10

GE to Drive Demand for Bakery Enzymes 10

Genetic Engineering Revolutionizes Vaccines 10

Plant Expression Systems to Replace Traditional Expression

Systems 11

Approved Gene Therapies Fail to Gather Momentum 12

P53 Gene Therapy - A Novel Approach in Cancer Treatment 12



The GM Food Issue Continues 13

Nations at Crossroads to Accept or Object GE Crops 13

Nations Set Global Agenda to Settle GM Crop Controversies 14

Challenges Confronting the Biotechs 14

Efficacy - The Key Challenge for Gene Therapy 14

Key Factors Affecting the Indian Biotechnology Industry 15



Genetic Engineering: A Fast Catching Trend in Developing

Countries 16

Future of GE Technologies 17

US: Owns a Lion's Share of the World Biotech Produce 17

Table 2: US Biotech Crop Produce By Year in Millions of

Hectares 17

GM Crops Fail to Live up to Expectations in the US 18

US Soybean and Corn Crop to Witness Robust Growth 18

FDA Compliance to Spur Growth in the US Biotech Industry 18

Canada Reaches Million Acres Mark 18

Table 3: Canadian Biotech Crop Produce by Leading Crops

(2011) 19


Table 4: Biotech Maize in Canada: Percentage Share Breakdown

by Varieties with Single Stacked gene, Two Stacked genes, and

Triple Stacked genes (2011) 19

Small and Medium Sized Biotech Enterprises to Grow in Europe 19

Germany and UK- The Hub of European Gene Therapy Market 20

Spain Garners Leading Spot in Europe's GM Maize Market 20

Table 5: Biotech Maize Hectarage in Europe (2011) 20

GMO Crops' Future Hinges on Co-Existence Measures in EU 21

European Commission Downplays Impact of GM Crops 21

Biotech Crops Remain in a Political Standstill in Europe 21

European Nations Ban GM Potato and Maize 21

UK Government's GM Crops Proposal Faces Rebuff 22

Spanish Transgenic Corn Plantation Increases 22

Ireland: A GM-free Zone 22

Gene Therapy Pipeline Strengthens in Asia 23

GM Foods Trends in Asia 23

Bt Cotton Fails in Asia 24

Chinese Biopharmaceutical Market to Continue its Growth Spurt 24

Government to Support Biopharmaceutical Innovation 24

Biotech Crop Research Gains Momentum in India 25

The Great Indian Bt Brinjal Controversy 25

India - The Leading Cultivator of Bt Cotton 25

India Ousts China in Bt Cotton Cultivation 25

Indian Agri-Bio Industry on a Roll 26

India: Ban on Genetically Engineered Crops? 26

Legalization of Genetic Engineering in Indonesia 26

GM Crops to Earn Good Returns for Australia 26

Biotechnology - A Boon for Agriculture in Malaysia 27

Poor Biotech Crops Adoption in Africa 27

Biotech Crops Cultivation Zooms in South Africa 27

Table 6: Percentage Share Breakdown of Biotech Maize by Type

(2011) in South Africa 28


Table 7: Percentage Share Breakdown of Biotech Cotton by Type

(2011) in South Africa 28

Uruguayan Community Resist GM Plants 28

GM Crop Adoption Rate Grows Exponentially in Brazil 28



The Concept 29

Molecular Basics - The Gene 30

Genome - The Information Pool 30

Evolution of Genetic Engineering 30

Historical Developments in Genetic Engineering: 31

The Human Genome Project 31

Significant Events in the Past 32

Gene Therapy 32

Types of Gene Therapy 33

Monogenic Gene Therapy 33

Suicide Gene Therapy 33

Antisense Gene Therapy 33

Human Genetic Engineering 33

Genetic Engineering in Animals 33

Role of Biotechnology in Agriculture 34

Insect Resistant Crops Vs. Herbicide Tolerant Crops 34

Some Interesting GM Crop Facts 35

Myths and Fads Associated to Genetically Engineered Crops 35

Improvement of Genetic Characters in Wheat 36

Agrobacterium tumifaciens Mediated Transformation 36

The Biolistic Transformation Method 37

Genetically Modified Foods 37

GM Food Faces Worldwide Criticism During Initial Years 37

Benefits of Genetically Modified Foods 38

Pest Resistance 39

Cold Tolerance 39

Herbicide Tolerance 39

Drought and Salinity Tolerance 39

Disease Resistance 39

Phytoremediation 40

Nutrition 40

Pharmaceuticals 40

Negative Impacts of GM Foods 40

Possibility of Crosspollination 40

Decreased Pesticides Effectiveness 40

Unintentional Destruction of Other Species 41

Health Concerns Related to GM Foods 41

Cost Concerns Related to GM Foods 41

Genetic Engineering and Food Processing 42

Genetic Engineering and Regulatory Environment 42

Patents - An Overview 43



Factors Influencing Gene Therapy's Future Development 44

Human Genome Analysis 44

Gene Therapy - The Next Generation Cardiovascular Therapy 44

Public Support for Gene Therapy 44

RNAi Bode Bright Prospects 44

Factors Hampering Gene Therapy Future Development 45

Stringent US and European Regulatory Laws Prolongs Gene

Therapy Development 45

Identifying Genetic Fault 45

Immune Response 45

Delivering Genetic Materials into Patient Cells 45

Multigene Disorders 46

Side Effects 46

Push Towards Germline Gene Transfer 46

Technical Limitations 46

Commercialization: A Road Uphill 47

Time Line in Gene Therapy Drug Development 47

Table 8: Gene Therapy Clinical Trials (2011): Percentage

Breakdown by Geographic Region for the US, Europe, Canada,

Japan and Rest of World 47


Table 9: Gene Therapy Clinical Development (2011):

Percentage Share Breakdown by Stage 48

Select Gene Therapy Products in Phase III Development (2010) 48

Select Gene Therapy Products in Phase II Development (2010) 49

Select Gene Therapy Products in Phase I and Pre-Clinical

Development (2010) 49

Target Diseases and Players Involved 50

Key Players by Application Area 50

Table 10: Clinical Development of Gene Therapy by Targeted

Indication (2011): Percentage Breakdown of Number of Trials

for Cancer Diseases, Cardiovascular Diseases, Infectious

Diseases, Monogenic Diseases, Neurological Diseases and

Others 50


Table 11: Gene Therapy Clinical Trials Worldwide (2011):

Percentage Breakdown by Gene Type Transferred - Antigen,

Cytokine, Tumor Suppressor, Growth Factor, Deficiency,

Suicide, and Others 51


Table 12: Gene Therapy Clinical Development by Vectors Used

(2011): Percentage Breakdown of Number of Trials for

Adenovirus, Retrovirus, Plasmid DNA, Vaccinia Virus,

Lipofection and Others 51

Gene Therapy Industry in Europe and the US - A Comparison 51



Definition of Gene Amplification 53

Target vs. Signal Amplification 53

Available Types of Gene Amplification Technologies 53

Polymerase Chain Reaction 53

The PCR comprises four major components: 53

Reagents and Equipment Required for PCR 54

Reaction Steps 54

Denaturation 54

Annealing 54

Extension 54

Detection of Amplified Product/DNA 55

(Q&Q) PCR 55

Reverse Transcriptase PCR (RT-PCR) 56

Alternative Technologies to PCR 56

OmniPlex 56

Genome-wide disease association studies 56

Pharmacogenomics studies 56

Molecular diagnostics and forensics 56

Additional OmniPlex Applications in Development 56

Strand Displacement Amplification 57

Ligase Chain Reaction 57

LCR Involves a Cyclic two-Step Reaction 57

Gene Amplification Technology (GAT) 57

Hybrid Capture 57

Isothermal DNA Amplification Techniques 58

Rolling Circle Amplification in Diagnostics 58

Ican Isothermal Gene Amplification Technology 58

BioHelix HDA Technology 58

Other Amplification Technologies 58

Signal Amplification Technology 58

Transcription Mediated Amplification 59

DNA Cleavage-based Signal Amplification 59

Ramification Amplification Method 59

End Use Market Analysis 59

Medical and Diagnostics 59

Role of Amplification Technology in the Diagnoses of

Infectious Diseases 60

Diagnosis of Infectious Diseases by PCR 60

Detection of Antimicrobial Resistance 61

PCR Based Nucleic Acid Amplification for Detection of

Antimicrobial Agents 61

Nucleic Acid Amplification Testing (NAT) 61

Nucleic Acid Amplification Methods 62

DNA Amplification Technology in the Diagnosis of Infectious

Diseases 62

Advantages 62

Limitations 62

Forensic and Paternity Testing 62

Food Safety 63

Table 13: Current and Future Analysis for Global Gene

Amplification Technology Market by Segment Independently

Analyzed with Annual Sales Figures in US$ Million for 2010

Through 2015 64


Table 14: Global Gene Amplification Market (2012): Percentage

Breakdown of Value Sales by Geographic Region- the US,

Canada, Japan, Europe and Rest of World 64















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