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Global Apoptosis Industry
Date:11/8/2011

ce: A Major Business Case for

Direct Apoptogens 12

Factors Encouraging Investments in Apoptosis Based Cancer Drugs 12

Rise in Cancer Incidences Fosters Growth in Cancer Related

Apoptosis Research 12

Low Entry Barriers in Cancer Research Encourages Cancer

Related Apoptosis Research 13

Government Funded Investments Bode Well for Cancer Related

Apoptosis Research 13

High Prices/Efficacy Encourage Pharmas in Pushing

Commercialization of Apoptosis-Based Anticancer Drugs 14

Kinase Inhibitors: Cutting Edge Second Generation of Indirect

Apoptogens 14

Table 7: World Market for Kinase Inhibitors (2010):

Breakdown of Sales (In US$ Million) of Key Kinase Inhibitor

Drugs (includes corresponding Graph/Chart) 15

Outlook 15

3. APOPTOSIS: A CONCEPTUAL OVERVIEW 16

Apoptosis: Definition 16

Importance of Apoptosis 16

Apoptosis Mechanism 17

Execution of Apoptosis 17

Dead Cell Removal 18

Apoptosis & Diseases 18

Faulty Apoptotic Pathways 18

Cancer 18

Non-Cancer Diseases 18

Neurodegeneration 19

Liver Diseases 19

Heart Diseases 19

Autoimmune Diseases 19

Categories of Apoptogens in the Marketplace 20

First Generation Indirect Apoptogens (IAs) 20

Second Generation Indirect Apoptogens (IAs) 20

Direct Apoptogens 20

How Apoptosis is Targeted in Disease Research 20

Role of Death Receptors in Apoptosis 21

TNF Receptor Signaling 21

Signaling by Fas (CD95) 21

Apoptosis Induction by TRAIL 22

Caspase Inhibitors & Activators 22

Role of Intrinsic (Mitochondrial) Death Pathways in Apoptosis 22

Bcl-2 Family Proteins 23

Targeting Mitochondria Directly 23

Role of IAPs (inhibitors of apoptosis proteins) in Apoptosis

Regulation 23

Tumor Suppressor p53 24

4. DRUG APPROVALS, INTRO
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