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Glenmark Initiates Phase IIb Human Trials Globally for its Novel Molecule 'Revamilast'
Date:8/10/2011

n Asthma and RA)

PDE 4 inhibitors represent class of therapeutic agents with a unique mechanism of action for the treatment of a range of chronic inflammatory disorders including COPD, asthma, rheumatoid arthritis, IBD and psoriasis. This mechanism of action of PDE4 inhibitors would be useful in treating chronic inflammatory conditions such as RA and asthma. Many manifestations of RA are significantly influenced by the effects of pro-inflammatory cytokines (e.g., TNF, IL-1, IL-6). In asthma, there remains a need for the development of novel anti-inflammatory therapies that are at least equally effective and possess a superior safety profile in comparison to corticosteroids.

PDE 4 inhibitors relax smooth muscles and attenuate the inflammatory response to a wide variety of stimuli and in particular suppress many cytokines, including TNF-α production in mononuclear cells. Therefore, PDE 4 inhibitors present a novel treatment opportunity for a range of chronic inflammatory diseases.

A first-in-class PDE 4 inhibitor, Roflumilast, has recently been approved in the European Union and in Mar'2011, Forest Laboratories Inc. and Nycomed A/S have received US FDA approval for Roflumilast to treat symptoms associated with severe chronic obstructive pulmonary disease (COPD).

Patient Population

Globally there are over 300 million asthma patients and over 20 million patients have RA. The current RA market is estimated at USD 26 billion and the Asthma market is estimated at USD 30 bn

About Glenmark Pharmaceuticals Ltd

Glenmark Pharmaceuticals Ltd. (GPL) is a research-driven, global, integrated pharmaceutical company headquartered at Mumbai, India. It is a leading player in the discovery of new molecules both NCEs (new chemical entity) and NBEs (new biological entity). Glenmark has eight molecules in various stages of clinical development and is primarily focused in the areas of Inflammation [asthma/COPD, rheumatoid arthritis etc.]
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SOURCE Glenmark Pharmaceuticals Ltd.
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