Navigation Links
Glenmark Initiates Phase IIb Human Trials Globally for its Novel Molecule 'Revamilast'
Date:8/10/2011

an volunteers treated with Revamilast suggests a good ex-vivo inhibition of the inflammatory marker TNF-α with maximum inhibition upto 93%. Based on these results and animal model data, it is expected that Revamilast would be beneficial in a variety of inflammatory disorders. Additionally, Revamilast does not appear to be metabolized to carcinogenic metabolites (ADCP N-oxide and ADCP N-oxide epoxide); and plasma samples from a Phase 1 study analyzed for such metabolites of Revamilast, showed no levels were detected in human plasma.

With the completion of several Phase I studies, Glenmark has initiated a global Phase IIb trial for Revamilast in patients with Asthma. Glenmark has already received approval from respective authorities in the UK, Poland, India and Czech Republic to conduct Phase IIb studies. Regulatory submissions have also been completed in Russia. The primary objective of this 12-week, double blind, placebo controlled, dose range finding study is to evaluate the effects of Revamilast at three doses on lung function (FEV1) in nearly 450 patients with chronic persistent Asthma.

Glenmark has also initiated another global Phase IIb trial with Revamilast in patients with Rheumatoid Arthritis. Glenmark has already received approval from the MHRA, UK, India, Poland and the Philippines to conduct Phase IIb studies for Rheumatoid Arthritis. Regulatory submissions have also been completed in Sri Lanka. The objective is to determine the efficacy of three doses of Revamilast compared to placebo in the treatment of more than 400 patients with active Rheumatoid Arthritis who showed an inadequate response to methotrexate.

In parallel to these two clinical studies, Glenmark is also conducting various other clinical and non-clinical studies to ensure timely entry into Phase III trials. Glenmark intends to initiate Phase III trials for at least one indication in the second half of FY 2012-13

PDE4 inhibitors (Impact o
'/>"/>

SOURCE Glenmark Pharmaceuticals Ltd.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related biology technology :

1. Glenmark Announces the Discovery of a Novel Chemical Entity GRC 17536, a TRPA1 Receptor Antagonist, a Potential First-in-Class Molecule Globally
2. Glenmarks Novel Molecule for Diabetes, Melogliptin to Enter Phase III Trials
3. SCRIP, the Leading Pharmaceutical Magazine in the World Crowns Glenmark as the "Best Pharma Company in the World - SME" and the "Best Company in Emerging Markets" at the SCRIP Awards 2008 in London
4. PAREXEL Partners with Glenmark to Win the Good Clinical Practice Journal Award for Most Innovative Patient Recruitment Strategy
5. BioMarin Initiates Phase 1 Trial for BMN 673 in Patients With Advanced Hematological Malignancies
6. InterMune Initiates Phase 3 ASCEND Study of Pirfenidone in IPF
7. GeoVax Initiates Third Site For Therapeutic Testing of Its HIV Vaccine
8. CrystalGenomics Initiates CG100649 Phase 2b Study in Patients with Osteoarthritis
9. Metabolex Initiates Phase 2 Trial of Arhalofenate
10. Isis Initiates Phase 1 Study of ISIS-TTRRx and Earns $5 Million Milestone Payment From GlaxoSmithKline
11. TissueGene Initiates Patient Enrollment for a Phase II Study of TG-C for Osteoarthritis of the Knee
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2014)... the Vienna University of Technology and the Maria ... perfect semiconductor crystals into a silicon nanowire. With ... fast and multi-functional processing units can be accommodated ... research results will be published in the journal ... the cornerstone of future chip technology, but the ...
(Date:7/23/2014)... 23, 2014  AuraSense Therapeutics, the pioneer in developing ... regulatory and immunotherapeutic agents, announced today that ... Therapeutics, executive leadership team as chief financial ... to joining AuraSense Therapeutics, Mr. Snyder was ... of Cellular Dynamics International Inc., where he ...
(Date:7/23/2014)... (PRWEB) July 23, 2014 Last year, ... Systems , a leading global provider of data management ... with TrialMaster, a leading-edge system for electronic data capture ... of universal design and study execution tools added TrialMaster ... and much anticipated version of Transform for TrialMaster, is ...
(Date:7/23/2014)... 23 de julio de 2014 ADB ... Compañía) ha anunciado hoy una asociación con Austen ... (ABIA o el Instituto), para el propósito de ... de terapia de señal bioeléctrica (el E-QURE BST ... Instituto, que tiene una importante experiencia en cicatrización ...
Breaking Biology Technology:A crystal wedding in the nanocosmos 2AuraSense Therapeutics Appoints Biotechnology Veteran David S. Snyder as Chief Financial Officer 2Formedix and OmniComm Systems® Partnership Strengthened with the Release of Enhanced TrialMaster® Integration for EDC Build 2Formedix and OmniComm Systems® Partnership Strengthened with the Release of Enhanced TrialMaster® Integration for EDC Build 3ADB International Group Inc. anuncia una asociación con Austen BioInnovation Institute 2ADB International Group Inc. anuncia una asociación con Austen BioInnovation Institute 3ADB International Group Inc. anuncia una asociación con Austen BioInnovation Institute 4ADB International Group Inc. anuncia una asociación con Austen BioInnovation Institute 5ADB International Group Inc. anuncia una asociación con Austen BioInnovation Institute 6
... decision last week to merge its Imaging and Printing Group ... Systems Group (IPSG) is a major milestone in HPs journey ... combining these two units, HP has a unified and convincing ... may be the key that turns HPs consumer message into ...
... researchers will show off developments in games that offer real-world ... ,The Academic Advanced Distributed Learning Co-Laboratory , WTN and ... how Games are Shaping Business and Learning, which will center ... applied to the workforce. , ,The video game industry has ...
... Business is booming again at the University of Wisconsin-Madisons ... job-seekers. , ,This is the best hiring situation weve seen ... associate director of ECS . Fall 2004 recruiting was ... are expected to attend Career Connection, the colleges spring job ...
Cached Biology Technology:HP charges toward the living room 2HP charges toward the living room 3Businesses and educators to preview video games for training 2Businesses and educators to preview video games for training 3Companies recruiting more UW engineering students 2Companies recruiting more UW engineering students 3Companies recruiting more UW engineering students 4
(Date:7/23/2014)... songbirds are disappearing, and though conservationists are examining several ... acid rain and light pollution, a key piece of ... go once they leave their breeding sites, and what ... To answer this question, a team of researchers out ... connectivity map produced for a songbird, using tracking from ...
(Date:7/23/2014)... DC -- The planet,s soil releases about 60 billion ... is far more than that released by burning fossil ... This enormous release of carbon is balanced by carbon ... other plant matter, as well as by the underground ... have documented that rising temperatures increase the rate of ...
(Date:7/23/2014)... in personalized cancer medicine, (the WIN consortium), recently announced ... Jefferson University will be one of its six ... group in the Tri-State Area. The goal of WIN ... to the patient by forging collaborations between partners in ... the WIN consortium means Jefferson cancer patients will have ...
Breaking Biology News(10 mins):York University researchers use bird 'backpacks' to put wood thrushes migration on the map 2Climate change and the soil 2New partnership brings more personalized cancer treatment to Philadelphia 2
... leave the pediatrician,s office if your child has strep ... treatment. A novel application for applying DNA "nanobarcodes" ... and more accurately determine what,s causing a patient,s acute ... R. Hartman, a Cornell University PhD candidate in Biological ...
... generation sequencing (NGS) and Genomatix Software GmbH, a leading ... data, announce their decision to combine their expertise and ... genome analysis and re-sequencing project services. "We are ... high level of expertise in understanding and interpretation of ...
... New Queen,s University research has shown that the growth of melanoma, ... slowed when a little known gene called MicroRNA 193b is added. ... miR-193b when he discovered that it was deficient in melanoma tumors ... The miRNA-193b gene is found in people,s DNA and was unknown ...
Cached Biology News:Instant testing for sore throats wins CIMIT prize 2Instant testing for sore throats wins CIMIT prize 3Instant testing for sore throats wins CIMIT prize 4
Schneider's Drosophila - Insect medium...
... includes protein separation by two-dimensional electrophoresis ... software package from Bio-Rad and protein ... order to meet customers requirements regarding ... and format of the results permanent ...
... Dual-Binary Analytical System more than doubles the ... LC/MS. The fast analysis cycles of the ... to 100% in tandem mode. Difficult separations ... Using backflush or heartcut configurations, on-line sample ...
... a molecular weight of 16 kDa. Leptin is ... by adipocytes [1,2]. Leptin is thought to play ... [1-3]. In the human, leptin levels are elevated ... A relationship between serum leptin levels and several ...
Biology Products: