Navigation Links
Glenmark Announces a New Discovery and the Initiation of IND Enabling Studies of a Novel Monoclonal Antibody Targeting OX40
Date:2/4/2013

d non-lymphoid cells. Costimulatory signals from OX40 to an activated T cell promote division and survival, augmenting the clonal expansion of effector and memory populations. OX40 mediated costimulatory signaling plays a central role in the development of multiple inflammatory and autoimmune diseases. Inhibiting these interactions can be used to treat these conditions. Conversely, agents that activate OX40 are being developed to activate T-cells to target cancer cells. No OX40 antagonistic antibodies are currently in clinical stage of development.

Glenmark's Novel Biologics Entity pipeline

With the addition of GBR 830 to the pipeline, Glenmark will now have three monoclonal antibodies in the Novel Biologics Entity (NBE) pipeline. First, GBR 500, a monoclonal antibody represents a first-in-class opportunity indicated for the treatment of Inflammatory Bowel Disease (IBD) and Multiple Sclerosis (MS). GBR 500 has been licensed to Sanofi and is in Phase II trials in the US. The second monoclonal antibody, GBR 900 targets the TrkA receptor for pain. This project is developed under license from Lay Line Genomics S.p.A., an Italian based Company. Monoclonal antibodies specific for TrkA represent a first-in-class opportunity for the treatment of chronic pain, which has a high level of unmet need. GBR 900 is in the pre-clinical stage of development and will be developed further by Glenmark Biologics Research Centre in Switzerland.

About Glenmark

Glenmark Pharmaceuticals Ltd. (GPL) is a research-driven, global, integrated pharmaceutical company. It is a leading player in the discovery of new molecules both NCEs (new chemical entity) and NBEs (new biological entity). Glenmark has a number of molecules in various stages of clinical development and is primarily focused in the areas of Inflammation (asthma/COPD, rheumatoid arthritis etc.) and Pain (neuropathic pain and inflammatory pain). The company has a significant presence
'/>"/>

SOURCE Glenmark Pharmaceuticals Ltd
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3

Related biology technology :

1. Keryx Biopharmaceuticals, Inc. Announces Upcoming Poster Presentations of Zerenex™ (Ferric Citrate) at the Upcoming American Society of Nephrology Kidney Week 2011 Annual Meeting
2. VaxyGen Assay Services, LLC Announces Launch of Custom Bioassay Services and Operations
3. Sequenom Announces Participation at the Lazard Capital Markets 8th Annual Healthcare Conference
4. ACORN Research, LLC Announces Partnership with AdeptBio, LLC
5. GeoVax Labs, Inc. Announces Nine Month 2011 Financial Results
6. WuXi PharmaTech Announces Third-Quarter 2011 Results
7. Chimerix Announces Late-Breaking Poster Presentation at Kidney Week 2011 Annual Meeting
8. Spherix Announces Third Quarter Financial Results
9. Modern Mobility Aids, Inc. Announces November 30, 2011 Closing of Lumigene Acquisition
10. MedImmune Announces Winners of Its 6th Annual Global Abstract Competition
11. Nile Therapeutics Announces Top-Line Results in Clinical Trial Evaluating the Subcutaneous Infusion of Cenderitide, Meets Primary Endpoint
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... 2014 Intarcia Therapeutics, Inc. today ... study of the cost and predictability of non-adherence in ... Annual Meeting of the European Association for the Study ... Christian Frois , Ph.D., of Analysis Group, Inc. presented ... Intarcia-sponsored, retrospective studies to characterize the prevalence of non-adherence ...
(Date:9/17/2014)... , Sept. 17, 2014 RXi ... biotechnology company focused on discovering, developing and commercializing ... RNA-targeted technologies, today announced that it has been granted ... Trademark Office on its unique delivery system for ... to phagocytic cells for the treatment of diseases ...
(Date:9/17/2014)... 2014 NASA’s MESSENGER has just celebrated ... is proud to have one of its latch valves, ... is a scientific investigation of the planet Mercury. It ... there, and has provided a vast amount of information ... of latch valves utilize solenoids that also include permanent ...
(Date:9/16/2014)... that can harvest energy from jaw movements has been ... It is hoped that the device can generate electricity ... of small-scale implantable or wearable electronic devices, such as ... devices. , The first results of the device,s performance ... journal Smart Materials and Structures . , Jaw ...
Breaking Biology Technology:Intarcia Reveals New Insights At EASD Meeting Characterizing The Burden Of Poor Control And Non-Adherence To Anti-Diabetic Therapies 2Intarcia Reveals New Insights At EASD Meeting Characterizing The Burden Of Poor Control And Non-Adherence To Anti-Diabetic Therapies 3Intarcia Reveals New Insights At EASD Meeting Characterizing The Burden Of Poor Control And Non-Adherence To Anti-Diabetic Therapies 4Intarcia Reveals New Insights At EASD Meeting Characterizing The Burden Of Poor Control And Non-Adherence To Anti-Diabetic Therapies 5RXi Pharmaceuticals Strengthens Intellectual Property Portfolio 2RXi Pharmaceuticals Strengthens Intellectual Property Portfolio 3RXi Pharmaceuticals Strengthens Intellectual Property Portfolio 4'Smart material' chin strap harvests energy from chewing 2
... Gen-Probe Incorporated,(Nasdaq: GPRO ) announced today that the ... Conference on May 1, 2008 at,approximately 4:20 p.m. Eastern ... may be accessed through a link on the investors ... will be,available for 30 days following the event., ...
... Mass., April 24 Idenix,Pharmaceuticals, Inc. (Nasdaq: ... a corporate overview at the upcoming Morgan Stanley ... at 3:00 p.m.,ET at The Ritz Carlton in ... webcast of the company presentation can be,accessed under ...
... Commission Expected by Mid-2008, COLLEGEVILLE, Pa. ... Pharmaceuticals, a division of Wyeth (NYSE: ... PGNX ), today announced that the companies,have ... subcutaneous injection from the Committee for Medicinal ...
Cached Biology Technology:Gen-Probe to Webcast Presentation at Morgan Stanley Global Healthcare Unplugged Conference 2Wyeth and Progenics Receive Positive Opinion From European Committee for RELISTOR for the Treatment of Opioid-Induced Constipation in Advanced-Illness Patients 2Wyeth and Progenics Receive Positive Opinion From European Committee for RELISTOR for the Treatment of Opioid-Induced Constipation in Advanced-Illness Patients 3Wyeth and Progenics Receive Positive Opinion From European Committee for RELISTOR for the Treatment of Opioid-Induced Constipation in Advanced-Illness Patients 4Wyeth and Progenics Receive Positive Opinion From European Committee for RELISTOR for the Treatment of Opioid-Induced Constipation in Advanced-Illness Patients 5
(Date:9/17/2014)... State,s Institute for the Arts and Humanities has received ... for a two-year project, "The Boundaries of the Human ... project will support a wide-ranging series of events aimed ... humanities. One involves artists and researchers who are exploring ... the idea of humanism, and the other involves the ...
(Date:9/17/2014)... has developed, very cleverly, some lessons on how to ... said Joseph Shaw, director of the Optical Technology Center ... structures at the nanoscale, we,ll discover them." , Some ... August during a conference called "The Nature of Light: ... of the University of Arizona College of Optical Sciences. ...
(Date:9/17/2014)... A team of Spanish researchers have obtained the first ... a sixteenth century pig found at the site of ... that this ancient pig is closely related to today,s ... pigs were crossed with modern Iberian pigs. , The ... on evolutionary aspects of pig species, and particularly on ...
Breaking Biology News(10 mins):Mellon Foundation awards grant for major project in the humanities and sciences 2Nature's designs inspire research into new light-based technologies 2Nature's designs inspire research into new light-based technologies 3Iberian pig genome remains unchanged after 5 centuries 2
... mechanism has been discovered in a microorganism that thrives in ... key processes in human cells, and in a better understanding ... study is published today in the online version the American ... group at the Department of Molecular Evolution at Uppsala University ...
... innate defence system against deadly bacteria. However, how the step ... not yet known. To date, B. Pseudomallei, a ... can remain hidden in the human body for many years ... suddenly become activated and spread throughout the body, resulting in ...
... Measures to tackle the human impact on biodiversity ... countries working with common goals and frameworks. This ... European Science Foundation (ESF), which moved towards establishing ... and biodiversity analysis on the back of existing ...
Cached Biology News:New cell division mechanism discovered 2European biodiversity and ecosystem scientists merge and gear up for long-term research 2
... C1 Plus is a modular confocal system ... with an ultra-compact and lightweight design. The ... Plusboost optical performance to 400nm andits bi-directional ... support for X and Y scan axes ...
... integrated digital microscope and camera system that ... optical adjustment or software installation. Built on ... combines simplicity and advanced technology for users ... viewing of a macro image and a ...
... The TUNEL-based assay kit provides complete ... cells for convenient detection of DNA ... sections. The incorporation of BrdU in ... biotinylated or digoxigenylated methods. Results can ...
... The Fujifilm Life Science LAS-3000 ... technology with a simplified user interface, ... a wide range of modularities. The ... applications, and the perfect standard system ...
Biology Products: