Navigation Links
Glenmark Announces a New Discovery and the Initiation of IND Enabling Studies of a Novel Monoclonal Antibody Targeting OX40
Date:2/4/2013

MUMBAI, February 4, 2013 /PRNewswire/ --

- GBR 830 is the First Antagonistic Antibody Targeting OX40 and is a Potential Global First-in-class Molecule

- OX40, Also Known as CD134, Plays a Key Role in T-cell Mediated Autoimmune Disorders

Glenmark Pharmaceuticals S.A. (GPSA), a wholly-owned subsidiary of Glenmark Pharmaceuticals Limited India (GPL), announces the discovery and initiation of IND enabling studies of a novel clinical development candidate, GBR 830, an anti-OX40 monoclonal antibody. GBR 830 has been discovered and developed by the Glenmark Biologics Research Centre located in La Chaux-de-Fonds, Switzerland. GBR 830, an anti-OX40 monoclonal antibody is a potential Global First-in-class molecule.

OX40 is a well-known target and the development of OX40 antagonists has been very challenging. Glenmark has achieved a significant milestone with the successful generation of an antagonistic OX40 monoclonal antibody coupled with generation of data validating the role of OX40 in autoimmune diseases.

GBR 830 shows great promise to emerge as a valuable therapeutic option to treat patients suffering from immune pathologies such as autoimmune diseases like Rheumatoid Arthritis (RA) and Inflammatory Bowel Disease (IBD).

Commenting on this milestone, Dr. Michael Buschle , Chief Scientific Officer & President - Biologics, Glenmark Pharmaceuticals mentioned, "GBR 830 is a tremendous achievement for us. No antagonistic antibodies targeting OX40 are currently in clinical stage of development. We are confident that the antibody expertise and product development capabilities of the Switzerland Biologics Research Centre will continue to enrich the Glenmark discovery pipeline."

About OX40

OX40 (CD134) is a member of the TNFR/TNF super family and is mainly expressed on activated CD4 and CD8 T cells as well as a number of other lymphoid an
'/>"/>

SOURCE Glenmark Pharmaceuticals Ltd
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3

Related biology technology :

1. Keryx Biopharmaceuticals, Inc. Announces Upcoming Poster Presentations of Zerenex™ (Ferric Citrate) at the Upcoming American Society of Nephrology Kidney Week 2011 Annual Meeting
2. VaxyGen Assay Services, LLC Announces Launch of Custom Bioassay Services and Operations
3. Sequenom Announces Participation at the Lazard Capital Markets 8th Annual Healthcare Conference
4. ACORN Research, LLC Announces Partnership with AdeptBio, LLC
5. GeoVax Labs, Inc. Announces Nine Month 2011 Financial Results
6. WuXi PharmaTech Announces Third-Quarter 2011 Results
7. Chimerix Announces Late-Breaking Poster Presentation at Kidney Week 2011 Annual Meeting
8. Spherix Announces Third Quarter Financial Results
9. Modern Mobility Aids, Inc. Announces November 30, 2011 Closing of Lumigene Acquisition
10. MedImmune Announces Winners of Its 6th Annual Global Abstract Competition
11. Nile Therapeutics Announces Top-Line Results in Clinical Trial Evaluating the Subcutaneous Infusion of Cenderitide, Meets Primary Endpoint
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... 17, 2014 Using microscopic polymer light resonators ... researchers at MIT,s Quantum Photonics Laboratory have developed ... the parts-per-billion range. Optical sensors are ideal for ... signal-to-noise ratio, compact, lightweight nature, and immunity to ... had been developed before, the MIT team conceived ...
(Date:7/10/2014)... observed the fractional quantum Hall effect in bilayer graphene ... be tuned by an electric field. , The ... confined to thin sheets are exposed to large magnetic ... thousands of individual electrons behave as a single system. ... well established, many details of this collective behavior remain ...
(Date:7/10/2014)... have shelled out for crude 3-D glasses, polarized ... experience. These basic devices, used to trick the ... soon be rendered obsolete with the introduction of ... researchers. , TAU doctoral students Yuval Yifat, Michal ... holography based on nanoantennas that could be used ...
(Date:1/15/2014)... an approach akin to assembling a club sandwich ... Technology (NIST) researchers have succeeded in crafting a ... flammability of foam commonly used in upholstered furniture ... the nanotube-coated polyurethane foam was reduced 35 percent ...
Breaking Biology Technology:Swell new sensors 2Columbia researchers observe tunable quantum behavior in bilayer graphene 2Columbia researchers observe tunable quantum behavior in bilayer graphene 3Projecting a 3-dimensional future 2Projecting a 3-dimensional future 3Layered security: Carbon nanotubes promise improved flame-resistant coating 2
... Jayne Garno, LSU associate professor of chemistry in the ... government,s highest honor for scientists and engineers in the ... Early Career Award for Scientists and Engineers, or PECASE. ... a prestigious award. LSU is a rich environment for ...
... DIEGO, Nov. 10, 2010 Anadys Pharmaceuticals, Inc. (Nasdaq: ... the Lazard 7th Annual Healthcare Conference on Wednesday, November 17, ... is being held at the St. Regis New York.  Steve ... provide an overview of Anadys and its clinical development programs. ...
... Dendreon Corporation (Nasdaq: DNDN ) today ... the post-approval supplement to the PROVENGE® (sipuleucel-T) Biologics ... manufacturing facility. Dendreon is requesting licensure for an ... U.S. Food and Drug Administration (FDA) review for ...
Cached Biology Technology:LSU’s Jayne Garno receives early career award from President 2Anadys Pharmaceuticals to Present at the Lazard Healthcare Conference 2Dendreon Submits Post-Approval Supplement to the PROVENGE Biologics License Application for New Jersey Manufacturing Facility 2
(Date:7/10/2014)... Institute for Basic Science (IBS), the main organization of ... Korea, has announced that a group of researchers, led ... technology in the field of optogenetics that can remotely ... new technology "OptoTrk" and it has succeeded with neuronal ... technology is that it requires only light to activate ...
(Date:7/10/2014)... vegetable oil found in your popcorn or soap might not ... even worse, according to an analysis in the Cell Press ... growing demand for vegetable oil has already led to the ... trouble for orangutans in particular. If guidelines are not put ... large-scale industrial plantations from Asia into Africa will be bad ...
(Date:7/10/2014)... ocean as a microbial megacity, teeming with life too ... hundreds of types of bacteria can be found. ... microbes have their own daily cyclesnot unlike the residents ... commute, work, and eat at the same times., What,s ... that need solar energy to help them photosynthesize food ...
Breaking Biology News(10 mins):New optogenetic tool for controlling neuronal signalling by blue light 2Hunger for vegetable oil means trouble for Africa's great apes 2New research finds ocean's most abundant organisms have clear daily cycles 2New research finds ocean's most abundant organisms have clear daily cycles 3
... Yale researchers describe a breakthrough in safe and effective ... molecules that silence genes the first step in development ... (STDs). The work is reported May 4 as an advance ... is a promising approach for prevention and treatment of human ...
... the cancer-causing effects of smoking tobacco, according to new ... in Thoracic Oncology (EMCTO), Lugano, Switzerland. Swiss ... to a cancer centre in St Gallen between 2000 ... when they developed the cancer, despite having smoked on ...
... MAY 3, 2009 Two scientists whose work has led ... muscular dystrophy have been chosen to receive the 2009 March ... Campbell, Ph.D. and Louis M. Kunkel, Ph.D., will share the ... the genes and proteins that cause muscular dystrophy, a disorder ...
Cached Biology News:Nanotechnology holds promise for STD drug delivery 2March of Dimes awards $250,000 prize to scientists unraveling the causes of muscular dystrophy 2
Monoclonal antibodies conjugated with rhodamine...
... p- methoxyhydrocinnamamido)-3′-deoxy-N,N-dimethyladenosine, 2HCl White ... Protein synthesis inhibitor. Inhibits translation by ... chains. Induces DNA fragmentation in thymocytes ... Purity: ≥98% by TLC. ...
Mouse monoclonal antibody to PPP2R2C - protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), gamma isoform...
...
Biology Products: